Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions.

Experiencing disasters causes severe mental disorders, among which post-traumatic stress disorder (PTSD) is the most common. We conducted a longitudinal study to examine the effect of 5-hydroxyl tryptamine transporter gene-linked polymorphic region (5-HTTLPR) genotype on child and adolescent PTSD symptom course after the 2008 Wenchuan Earthquake. We genotyped 963 participants who personally experienced the earthquake. PTSD symptoms were measured by University of California, Los Angeles PTSD reaction index at 2.5, 3.5, 4.5 and 5.5 years after the earthquake, respectively. Latent growth model was utilised to examine the main effect and gene-environment interaction effect of 5-HTTLPR on PTSD's symptom course. 5-HTTLPR genotype predicted initial PTSD symptom severity (β = 0.108, p = .019) and rates of symptom recovery (β = -0.120, p = .031) between 2.5 and 5.5 years. Compared with L' allele carriers, those with S'S' genotype showed higher initial symptom severity but also faster recovery rate. 5-HTTLPR genotype only predicted symptom severity at 2.5 years after the earthquake, after controlling for sex, age, ethnicity and trauma severity (β = 0.108, p = .019). This is the first evidence of the effect of 5-HTTLPR genotype on child and adolescent PTSD symptoms longitudinally, offering a novel perspective on the effect of 5-HTTLPR on PTSD symptom development following trauma exposure.

[1]  J. Su,et al.  Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences , 2018, Development and Psychopathology.

[2]  A. Amstadter,et al.  A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress , 2018, Depression and anxiety.

[3]  Suhua Chang,et al.  An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene , 2017, Neuroscience & Biobehavioral Reviews.

[4]  A. La Greca,et al.  Posttraumatic Stress Symptom Trajectories Among Children After Disaster Exposure: A Review. , 2017, Journal of traumatic stress.

[5]  M. Stein.  Genomics of Posttraumatic Stress Disorder: Sequencing Stress and Modeling Misfortune , 2017, Biological Psychiatry.

[6]  Dan J Stein,et al.  The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium , 2015, Psychological Medicine.

[7]  C. Nievergelt,et al.  The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration , 2015, Neuropsychopharmacology.

[8]  Hai Lin,et al.  Lessons Learned from Whole Exome Sequencing in Multiplex Families Affected by a Complex Genetic Disorder, Intracranial Aneurysm , 2015, PloS one.

[9]  M. Hauser,et al.  An Examination of the Association between 5-HTTLPR, Combat Exposure, and PTSD Diagnosis among U.S. Veterans , 2015, PloS one.

[10]  A. Serretti,et al.  The 5-HTTLPR polymorphism and posttraumatic stress disorder: a meta-analysis. , 2013, Journal of traumatic stress.

[11]  J. Sánchez-Meca,et al.  Meta-Analyses of the 5-HTTLPR Polymorphisms and Post-Traumatic Stress Disorder , 2013, PloS one.

[12]  S. Southwick,et al.  Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: a pilot study. , 2013, Journal of affective disorders.

[13]  J. Belsky,et al.  Serotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studies , 2012, Translational Psychiatry.

[14]  P. Moorjani,et al.  Corticotrophin-Releasing Hormone Type 1 Receptor Gene (CRHR1) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients , 2011, Disease markers.

[15]  Q. Cordeiro,et al.  Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF , 2011, Journal of Molecular Neuroscience.

[16]  K. Felmingham,et al.  Preliminary Evidence of the Short Allele of the Serotonin Transporter Gene Predicting Poor Response to Cognitive Behavior Therapy in Posttraumatic Stress Disorder , 2010, Biological Psychiatry.

[17]  M. Stein,et al.  Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. , 2009, Archives of general psychiatry.

[18]  A. Amstadter,et al.  Gene-environment interaction in posttraumatic stress disorder: an update. , 2009, Journal of traumatic stress.

[19]  U. John,et al.  Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. , 2009, The American journal of psychiatry.

[20]  A. Amstadter,et al.  Genetics of post‐traumatic stress disorder: Informing clinical conceptualizations and promoting future research , 2008, American journal of medical genetics. Part C, Seminars in medical genetics.

[21]  A. Steinberg,et al.  The University of California at Los Angeles post-traumatic stress disorder reaction index , 2004, Current psychiatry reports.

[22]  J. Mervis.  Aid to Minority Schools Is Political Hot Potato , 2003, Science.

[23]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[24]  Sue-Huei Chen,et al.  Posttraumatic stress reactions in children and adolescents one year after the 1999 Taiwan chi‐chi earthquake , 2002 .

[25]  W. Yule.  Post-traumatic stress disorder in children and adolescents , 2001 .

[26]  K K Kidd,et al.  Population studies of polymorphisms of the serotonin transporter protein gene. , 1999, American journal of medical genetics.

[27]  M. Stein,et al.  Full and partial posttraumatic stress disorder: findings from a community survey. , 1997, The American journal of psychiatry.

[28]  Yogesh K. Dwivedi,et al.  Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis. , 2018, Journal of affective disorders.

[29]  P. Fisher,et al.  Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism. , 2016, Social cognitive and affective neuroscience.

[30]  David Goldman,et al.  An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. , 2005, Alcoholism, clinical and experimental research.

[31]  P. Bentler,et al.  Cutoff criteria for fit indexes in covariance structure analysis : Conventional criteria versus new alternatives , 1999 .