论文信息 - Synthesis of protected aminoalkyl sulfinyl dilactones from α-amino acids

Synthesis of protected aminoalkyl sulfinyl dilactones from α-amino acids

Aim To synthesize protected aminoalkyl sulfinyl dilactones which were useful as the synthetic intermediates or the C- terminal pharmacophores of potential peptidomimetic proteasome inhibitors. Methods Organic reactions such as reduction, oxidation, olefination, and dihydroxylation were used. Results A convenient synthetic procedure to afford a series of aminoalkyl sulfinyl dilactones was presented, which would be useful in the synthesis of five- or six-member sulfinyl dilactones. Conclusion

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