2012: The Connectome, WBE and AGI

In order to grasp the entire complexity of the human nervous system, one needs to understand its physical substrate. Down to which level should a whole brain emulation keep all the structural details of the brain in order to achieve all of the functions of the biological brain? While a computer program could easily be emulated in order to achieve the same specified function, the human brain is a special case because of its enormously complex functions. For this reason, causal relations between brain structure and function are currently being made in neuroscience. Neuroscientific research is in this sense supporting WBE and therefore AGI, by providing important data, models and simulations of brain functions. The goals of this paper are to review the challenges for gathering and assembling connectome data and to provide directions for overcoming these challenges. Finally, the implications for AGI will be discussed.

[1]  B. Roth,et al.  Remote Control of Neuronal Signaling , 2011, Pharmacological Reviews.

[2]  Suhasa B. Kodandaramaiah,et al.  Automated whole-cell patch clamp electrophysiology of neurons in vivo , 2012, Nature Methods.

[3]  Rafael Yuste,et al.  Imaging Voltage in Neurons , 2011, Neuron.

[4]  W. Denk,et al.  The Big and the Small: Challenges of Imaging the Brain’s Circuits , 2011, Science.

[5]  W. Denk,et al.  Two-photon laser scanning fluorescence microscopy. , 1990, Science.

[6]  Rafael Yuste,et al.  Multiphoton stimulation of neurons and spines. , 2012, Cold Spring Harbor protocols.

[7]  R. W. Draft,et al.  Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system , 2007, Nature.

[8]  R. Yuste,et al.  The Brain Activity Map Project and the Challenge of Functional Connectomics , 2012, Neuron.

[9]  Christine Grienberger,et al.  Imaging Calcium in Neurons , 2012, Neuron.

[10]  Diana Deca,et al.  AVAILABLE TOOLS FOR WHOLE BRAIN EMULATION , 2012 .

[11]  Ju Lu,et al.  The Interscutularis Muscle Connectome , 2009, PLoS biology.

[12]  Michael L. Roukes,et al.  Iop Publishing Journal of Micromechanics and Microengineering Dual-side and Three-dimensional Microelectrode Arrays Fabricated from Ultra-thin Silicon Substrates , 2022 .

[13]  Ju Lu,et al.  Correction: The Interscutularis Muscle Connectome , 2009, PLoS Biology.

[14]  Nathalie L Rochefort,et al.  Functional mapping of single spines in cortical neurons in vivo , 2011, Nature.

[15]  B. Yates,et al.  revealed by transneuronal tracing Neural circuits controlling diaphragm function in the cat , 2008 .

[16]  Michael Z. Lin,et al.  Toward the Second Generation of Optogenetic Tools , 2010, The Journal of Neuroscience.