Therapeutic implications of autophagy in cancer treatment

Autophagy is a survival process in which a cell preserves its own components in case of nutrient deprivation by recycling its digested contents and cannibalizing itself. It is characterized by the double membrane autophagosomes formation and it has a fantastic role in cancer treatment by many mechanisms. Interestingly, Autophagy has a great effect in the treatment of many diseases by different mechanisms. Autophagy has been included as a treatment mechanism of various diseases by cell losing, such as degenerative diseases of the muscle and nervous system. It has been found abundant of autophagic vacuoles inside the damaged cells in many of these degenerative disorders. Autophagy can help both living cells and cancer cells to survive so when the strategy of the treatment of cancer decreases autophagy process of cancer cells, it prevents them to survive and divide. In this review, we illustrated the definition of autophagy, autophagic pathways, therapeutic implications of autophagy, the relationship between autophagy and cell death, inflammation, and necrosis.

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