Current status of radioactive seed for localization of non palpable breast lesions.

BACKGROUND Wire-localized breast biopsy (WLBB) remains the standard method for the surgical excision of nonpalpable breast lesions. Because of many of its shortcomings, most important a high microscopic positive margin rate, alternative approaches have been described, including radioactive seed localization (RSL). This review highlights the literature regarding RSL, including safety, the ease of the procedure, billing, and oncologic outcomes. METHODS Medline and PubMed were searched using the terms "radioactive seed" and "breast." All peer-reviewed studies were included in this review. CONCLUSIONS RSL is a promising approach for the resection of nonpalpable breast lesions. It is a reliable and safe alternative to WLBB. RSL is at least equivalent compared with WLBB in terms of the ease of the procedure, removing the target lesion, the volume of breast tissue excised, obtaining negative margins, avoiding a second operative intervention, and allowing for simultaneous axillary staging.

[1]  S. Feig,et al.  Migration of breast biopsy localization wire. , 1988, AJR. American journal of roentgenology.

[2]  J. Friedland,et al.  Randomized Prospective Evaluation of a Novel Technique for Biopsy or Lumpectomy of Nonpalpable Breast Lesions: Radioactive Seed Versus Wire Localization , 2001, Annals of Surgical Oncology.

[3]  M. Ernst,et al.  Wire localization of non-palpable breast lesions: out of date? , 2002, Breast.

[4]  L. Taylor,et al.  STANDARDS FOR PROTECTION AGAINST RADIATION. , 1970 .

[5]  S. Mclaughlin,et al.  Influence of frozen-section analysis of sentinel lymph node and lumpectomy margin status on reoperation rates in patients undergoing breast-conservation therapy. , 2008, Journal of the American College of Surgeons.

[6]  P. Karstaedt,et al.  Radioactive seed localization of nonpalpable breast lesions is better than wire localization. , 2004, American journal of surgery.

[7]  L. Jacobs,et al.  Positive Margins: The Challenge Continues for Breast Surgeons , 2008, Annals of Surgical Oncology.

[8]  S. Mclaughlin,et al.  A Multi‐site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization , 2008, The breast journal.

[9]  P. Karstaedt,et al.  Radiation safety with use of I-125 seeds for localization of nonpalpable breast lesions. , 2006, Academic radiology.

[10]  R. Kilcoyne,et al.  Complications of needle localization of foreign bodies and nonpalpable breast lesions. , 1988, Archives of surgery.

[11]  M. Morrow,et al.  The Effect of Multiple Reexcisions on the Risk of Local Recurrence After Breast Conserving Surgery , 2007, Annals of Surgical Oncology.

[12]  M. Homer,et al.  Needle localization of occult breast lesions with a curved-end retractable wire: technique and pitfalls. , 1986, Radiology.

[13]  R. J. Brenner,et al.  Wire fragments after needle localization. , 1996, AJR. American journal of roentgenology.

[14]  M. Homer.  Transection of the localization hooked wire during breast biopsy. , 1983, AJR. American journal of roentgenology.

[15]  V. Klimberg,et al.  Hematoma-Directed Ultrasound-Guided (HUG) Breast Lumpectomy , 2006, Annals of Surgical Oncology.

[16]  P. Venugopal,et al.  Radioactive Seed Localization Breast Biopsy and Lumpectomy: Can Specimen Radiographs Be Eliminated? , 2003, Annals of Surgical Oncology.