Two Complement Receptor One alleles have opposing associations with 1 cerebral malaria and interact with α + thalassaemia . 2 3

3 D. Herbert Opi, Olivia V. Swann, Alex Macharia, Sophie Uyoga, Gavin Band, 4 Carolyne Ndila, Ewen M. Harrison, Mahamadou A. Thera, Abdoulaye K. Kone, 5 Dapa A. Diallo, Ogobara K. Doumbo, Kirsten E. Lyke, Christopher V. Plowe, 6 Joann M. Moulds, Mohammed Shebe, Neema Mturi, Norbert Peshu, Kathryn 7 Maitland, Ahmed Raza, Dominic P. Kwiatkowski, Kirk A. Rockett, Thomas N. 8 Williams, J. Alexandra Rowe 9 Kenya Medical Research Institute-Wellcome Trust Research Programme, P. O. Box 10 230, Kilifi, 80108, Kenya. Centre for Immunity, Infection and Evolution, Institute of 11

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