In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

[1]  Bin Zhang,et al.  PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse , 2011, Nucleic Acids Res..

[2]  Matthias Mann,et al.  In vivo quantitative proteomics: the SILAC mouse. , 2011, Methods in molecular biology.

[3]  Prakash Gangadaran,et al.  Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma , 2012, BMC Cancer.

[4]  M. Mann,et al.  β1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation , 2011, Proceedings of the National Academy of Sciences.

[5]  M. Mann,et al.  Large-scale phosphosite quantification in tissues by a spike-in SILAC method , 2011, Nature Methods.

[6]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[7]  M. Mann,et al.  Andromeda: a peptide search engine integrated into the MaxQuant environment. , 2011, Journal of proteome research.

[8]  Cathryn M. Gould,et al.  Phospho.ELM: a database of phosphorylation sites—update 2011 , 2010, Nucleic acids research.

[9]  Damian Szklarczyk,et al.  The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored , 2010, Nucleic Acids Res..

[10]  Matthias Mann,et al.  Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics , 2011, Nature Protocols.

[11]  Hongmei Yu,et al.  Forcing form and function: biomechanical regulation of tumor evolution. , 2011, Trends in cell biology.

[12]  Akhilesh Pandey,et al.  Phosphoproteomics in cancer , 2010, Molecular oncology.

[13]  Paul A. Khavari,et al.  Invasive 3-Dimensional Organotypic Neoplasia from Multiple Normal Human Epithelia , 2010, Nature Medicine.

[14]  S. Tsao,et al.  p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients , 2010, Proceedings of the National Academy of Sciences.

[15]  S. Strömblad,et al.  Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover , 2010, Molecular biology of the cell.

[16]  S. Hanash,et al.  The grand challenge to decipher the cancer proteome , 2010, Nature Reviews Cancer.

[17]  M. Mann,et al.  Proteome, phosphoproteome, and N-glycoproteome are quantitatively preserved in formalin-fixed paraffin-embedded tissue and analyzable by high-resolution mass spectrometry. , 2010, Journal of proteome research.

[18]  Benjamin Geiger,et al.  The switchable integrin adhesome , 2010, Journal of Cell Science.

[19]  John C. Dawson,et al.  The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion , 2010, Current Biology.

[20]  S. Weiss,et al.  MT1-MMP controls human mesenchymal stem cell trafficking and differentiation. , 2010, Blood.

[21]  Anushya Muruganujan,et al.  PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium , 2009, Nucleic Acids Res..

[22]  Karlyne M. Reilly,et al.  Genetically engineered mouse models in cancer research. , 2010, Advances in cancer research.

[23]  Tony Pawson,et al.  Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells , 2009, Science.

[24]  D. Morrison,et al.  Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling , 2009, Molecular and Cellular Biology.

[25]  K. Kiguchi,et al.  Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications , 2009, Nature Protocols.

[26]  M. Baccarini,et al.  Raf-1 addiction in Ras-induced skin carcinogenesis. , 2009, Cancer cell.

[27]  Da-Qiang Li,et al.  PAK Signaling in Oncogenesis , 2009, Oncogene.

[28]  Doug Allen,et al.  Driving on Biomass , 2009, Science.

[29]  M. Stratton,et al.  The cancer genome , 2009, Nature.

[30]  C. Eyers Universal sample preparation method for proteome analysis , 2009 .

[31]  Rasiah Loganantharaj,et al.  Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion , 2009, Molecular Cancer.

[32]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[33]  M. Mann,et al.  Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. , 2008, Journal of proteome research.

[34]  M. Cheang,et al.  Loss of desmoglein 1 expression associated with worse prognosis in head and neck squamous cell carcinoma patients , 2008, Pathology.

[35]  P. Bork,et al.  Linear Motif Atlas for Phosphorylation-Dependent Signaling , 2008, Science Signaling.

[36]  M. Mann,et al.  SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function , 2008, Cell.

[37]  W. Muller,et al.  Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer , 2008, Journal of Mammary Gland Biology and Neoplasia.

[38]  T. Harris,et al.  Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation* , 2008, Journal of Biological Chemistry.

[39]  Allegra Via,et al.  Phospho.ELM: a database of phosphorylation sites—update 2008 , 2007, Nucleic Acids Res..

[40]  S. Eschrich,et al.  The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis , 2008, BMC Medical Genomics.

[41]  Laura A. Sullivan,et al.  Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer , 2007, Cell.

[42]  Michael L. Creech,et al.  Integration of biological networks and gene expression data using Cytoscape , 2007, Nature Protocols.

[43]  P. Bork,et al.  Systematic Discovery of In Vivo Phosphorylation Networks , 2007, Cell.

[44]  M. Marinkovich,et al.  Laminin 332 in squamous-cell carcinoma , 2007, Nature Reviews Cancer.

[45]  A. Hayday,et al.  Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis , 2007, Proceedings of the National Academy of Sciences.

[46]  M. Cetron,et al.  Biodiesel production : a preliminary study from Jatropha Curcas , 2013 .

[47]  Steven P. Gygi,et al.  Large-scale phosphorylation analysis of mouse liver , 2007, Proceedings of the National Academy of Sciences.

[48]  M. Mann,et al.  In-gel digestion for mass spectrometric characterization of proteins and proteomes , 2006, Nature Protocols.

[49]  M Peter Marinkovich,et al.  Tumour microenvironment: laminin 332 in squamous-cell carcinoma. , 2007, Nature reviews. Cancer.

[50]  M. Mann,et al.  Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips , 2007, Nature Protocols.

[51]  Matthias Mann,et al.  Innovations: Functional and quantitative proteomics using SILAC , 2006, Nature Reviews Molecular Cell Biology.

[52]  M. Mann,et al.  Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks , 2006, Cell.

[53]  W. Sterry,et al.  Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling , 2006, Molecular Cancer.

[54]  P. Purushottamachar,et al.  Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. , 2006, Bioorganic & medicinal chemistry.

[55]  F. Kokocinski,et al.  Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development , 2006, Oncogene.

[56]  S. Gygi,et al.  An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets , 2005, Nature Biotechnology.

[57]  R. Keri,et al.  Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice , 2005, Oncogene.

[58]  P. Roepstorff,et al.  Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns* , 2005, Molecular & Cellular Proteomics.

[59]  T. Pawson,et al.  Protein phosphorylation in signaling--50 years and counting. , 2005, Trends in biochemical sciences.

[60]  M. Landthaler,et al.  Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma , 2005, Modern Pathology.

[61]  Ming Zhou,et al.  Regulation of Raf-1 by direct feedback phosphorylation. , 2005, Molecular cell.

[62]  G. Landberg,et al.  Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior , 2004, Modern Pathology.

[63]  V. Thorsson,et al.  Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells*S , 2004, Molecular & Cellular Proteomics.

[64]  A. Heck,et al.  Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. , 2004, Analytical chemistry.

[65]  H. Kurzen,et al.  Expression of desmosomal proteins in squamous cell carcinomas of the skin , 2003, Journal of cutaneous pathology.

[66]  Takashi Matsumoto,et al.  Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis. , 2003, Cancer research.

[67]  S. Strömblad,et al.  p21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration , 2002, The Journal of cell biology.

[68]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[69]  M. Mann,et al.  Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics* , 2002, Molecular & Cellular Proteomics.

[70]  E. Manser,et al.  The Mechanism of PAK Activation , 2001, The Journal of Biological Chemistry.

[71]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[72]  R. Timpl,et al.  Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes , 2000, The EMBO journal.

[73]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[74]  J. DiGiovanni,et al.  Multistage carcinogenesis in mouse skin. , 1992, Pharmacology & therapeutics.

[75]  K. Gould,et al.  Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity , 1988, Molecular and cellular biology.

[76]  Eugenio Santos,et al.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene , 1982, Nature.