A note on spatial-motor deficits in patients with Huntington's disease: a test of a hypothesis.

Abstract It has been previously demonstrated that the caudate nucleus plays a role in a system for ego-centric spatial localization. It was hypothesized that the caudate would also be involved in the compensation for self-produced movement required by such a system. A direct test of this hypothesis revealed that patients with Huntington's Disease, which affects the caudate nucleus, were impaired in a task embodying this compensation function but were unimpaired in other equally difficult spatial-motor tasks not involving this function.