Biological targets and mechanisms of action of natural products from marine cyanobacteria.
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[1] Jiyong Hong,et al. Largazole: from discovery to broad-spectrum therapy. , 2012, Natural product reports.
[2] J. Wade Harper,et al. Drug discovery in the ubiquitin–proteasome system , 2006, Nature Reviews Drug Discovery.
[3] Qi-Yin Chen,et al. Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity , 2014, Journal of medicinal chemistry.
[4] Roberto Dominguez,et al. Actin structure and function. , 2011, Annual review of biophysics.
[5] S. Matthew,et al. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. , 2008, Journal of natural products.
[6] Roger G. Linington,et al. Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. , 2009, Journal of natural products.
[7] P. Scheuer,et al. Kulokekahilide-1, a cytotoxic depsipeptide from the cephalaspidean mollusk Philinopsis speciosa. , 2002, The Journal of organic chemistry.
[8] Marcy J. Balunas,et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. , 2013, Journal of natural products.
[9] V. Paul,et al. Combinatorial Strategies by Marine Cyanobacteria: Symplostatin 4, an Antimitotic Natural Dolastatin 10/15 Hybrid that Synergizes with the Coproduced HDAC Inhibitor Largazole , 2009, Chembiochem : a European journal of chemical biology.
[10] D. Botstein,et al. A gene expression database for the molecular pharmacology of cancer , 2000, Nature Genetics.
[11] Phillip Crews,et al. Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. , 2003, The Journal of organic chemistry.
[12] Wei Zhang,et al. Total synthesis of grassystatin A, a probe for cathepsin E function. , 2012, Bioorganic & medicinal chemistry.
[13] Youichi Fujii,et al. Isolation of dolastatins 10–15 from the marine mollusc dolabella auricularia☆☆☆ , 1993 .
[14] K. Abboud,et al. Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. , 2008, Organic letters.
[15] R. Shoemaker. The NCI60 human tumour cell line anticancer drug screen , 2006, Nature Reviews Cancer.
[16] W. Gerwick,et al. Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin. , 1999, Archives of biochemistry and biophysics.
[17] J. Pelletier,et al. Target identification using drug affinity responsive target stability (DARTS). , 2009, Proceedings of the National Academy of Sciences of the United States of America.
[18] O. Hurko. Target-based drug discovery, genetic diseases, and biologics , 2012, Neurochemistry International.
[19] L. Ekonomou,et al. Is copper chelation an effective anti-angiogenic strategy for cancer treatment? , 2013, Medical hypotheses.
[20] A. Ganesan,et al. Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery. , 2009, Current cancer drug targets.
[21] V. Paul,et al. Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. , 2008, Journal of the American Chemical Society.
[22] Jonathan Puddick,et al. Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. , 2010, Journal of natural products.
[23] Andrew T. Fenley,et al. The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β‐Epoxyketone Warhead from a Marine Cyanobacterium , 2012, ChemBioChem.
[24] Richard E. Moore,et al. Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin 12, lyngbyastatin 1, and lyngbyastatin 3 from , 2003, Journal of natural products.
[25] R. De Francesco,et al. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[26] W. Gerwick,et al. Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. , 2008, Journal of natural products.
[27] Yechun Xu,et al. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. , 2012, Journal of medicinal chemistry.
[28] W. Gerwick,et al. Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula , 2000 .
[29] W. Gerwick,et al. Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium , 2006 .
[30] S. Matthew,et al. Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. , 2007, Journal of natural products.
[31] Herbert Waldmann,et al. Target identification for small bioactive molecules: finding the needle in the haystack. , 2013, Angewandte Chemie.
[32] S. Merajver,et al. Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[33] W. Gerwick,et al. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits , 2010, BMC Neuroscience.
[34] Roger G. Linington,et al. Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. , 2011, Chemistry.
[35] R. Bates,et al. Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments. , 2003, Journal of molecular biology.
[36] Xuedong Liu,et al. Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1) , 2012, PloS one.
[37] W. Gerwick,et al. The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria. , 2010, Journal of natural products.
[38] B. Law,et al. Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor , 2010, Journal of Pharmacology and Experimental Therapeutics.
[39] Christian A. Rees,et al. Systematic variation in gene expression patterns in human cancer cell lines , 2000, Nature Genetics.
[40] L. Pirola,et al. Therapeutic potential of activators and inhibitors of sirtuins , 2010, BioFactors.
[41] K. Suenaga,et al. Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia , 1996 .
[42] Jessica E. Bolden,et al. Anticancer activities of histone deacetylase inhibitors , 2006, Nature Reviews Drug Discovery.
[43] G. Harrigan,et al. The cyanobacterial origin of potent anticancer agents originally isolated from sea hares. , 2002, Current medicinal chemistry.
[44] W. Gerwick,et al. The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons. , 2005, Toxicology letters.
[45] David J Newman,et al. Natural products as sources of new drugs over the 30 years from 1981 to 2010. , 2012, Journal of natural products.
[46] Brian C. Smith,et al. Mechanisms and molecular probes of sirtuins. , 2008, Chemistry & biology.
[47] N. Gray,et al. Targeting cancer with small molecule kinase inhibitors , 2009, Nature Reviews Cancer.
[48] W. Kolch,et al. The secret life of kinases: functions beyond catalysis , 2011, Cell Communication and Signaling.
[49] Jiyong Hong,et al. Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. , 2014, ACS medicinal chemistry letters.
[50] D. Sept,et al. Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin. , 2004, Biochemistry.
[51] W. Gerwick,et al. Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. , 2002, Journal of natural products.
[52] G. Chlipala,et al. Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery. , 2011, Current drug targets.
[53] S. Carmeli,et al. Action of tolytoxin on cell morphology, cytoskeletal organization, and actin polymerization. , 1993, Cell motility and the cytoskeleton.
[54] William H Gerwick,et al. The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore , 2002, Journal of Pharmacology and Experimental Therapeutics.
[55] Hiroaki Sasaki,et al. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. , 2011, ACS chemical biology.
[56] T. Kouzarides. Chromatin Modifications and Their Function , 2007, Cell.
[57] W. Gerwick,et al. Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula , 1994 .
[58] H. Luesch,et al. The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog , 2003, International journal of cancer.
[59] C. Smith,et al. Cryptophycin: a new antimicrotubule agent active against drug-resistant cells. , 1994, Cancer research.
[60] V. Paul,et al. Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. , 2001, Journal of the American Chemical Society.
[61] Olivier Elemento,et al. Using transcriptome sequencing to identify mechanisms of drug action and resistance , 2011, Nature chemical biology.
[62] L. T. Tan. Pharmaceutical agents from filamentous marine cyanobacteria. , 2013, Drug discovery today.
[63] Yuqing Liu,et al. Total synthesis and biological evaluation of grassypeptolide A. , 2013, Chemistry.
[64] M. Bogyo,et al. The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. , 2012, Chemistry & biology.
[65] A. Hopkins,et al. The druggable genome , 2002, Nature Reviews Drug Discovery.
[66] E. Sausville,et al. Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin. , 2001, Molecular pharmacology.
[67] B. Law,et al. Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation , 2009, Molecular Pharmacology.
[68] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[69] V. Paul,et al. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. , 2001, Journal of natural products.
[70] G. Larson,et al. Interaction of the antitumor compound cryptophycin-52 with tubulin. , 2000, Biochemistry.
[71] Herbert Waldmann,et al. From protein domains to drug candidates – natural products as guiding principles in , 2002 .
[72] H. Kwak,et al. In Vitro and In Vivo Osteogenic Activity of Largazole. , 2011, ACS medicinal chemistry letters.
[73] W. Gerwick,et al. Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula , 2005 .
[74] H. Overkleeft,et al. Proteasome inhibitors: an expanding army attacking a unique target. , 2012, Chemistry & biology.
[75] M. K. Harper,et al. Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. , 2009, Bioorganic & medicinal chemistry.
[76] S. Matthew,et al. Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. , 2010, Journal of natural products.
[77] Lik Tong Tan,et al. Bioactive natural products from marine cyanobacteria for drug discovery. , 2007, Phytochemistry.
[78] M. Jordan,et al. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. , 1998, Current opinion in cell biology.
[79] J. R. Somoza,et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. , 2004, Structure.
[80] Herbert Waldmann,et al. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. , 2002, Angewandte Chemie.
[81] W. Gerwick,et al. Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels , 2010, Journal of Pharmacology and Experimental Therapeutics.
[82] W. Gerwick,et al. Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. , 2008, Journal of natural products.
[83] R. Payne,et al. Total synthesis and antimalarial activity of symplostatin 4. , 2010, Organic letters.
[84] G. Schulz,et al. Binding structure of elastase inhibitor scyptolin A. , 2003, Chemistry & biology.
[85] L. T. Tan. Filamentous tropical marine cyanobacteria: a rich source of natural products for anticancer drug discovery , 2010, Journal of Applied Phycology.
[86] M. Bagherzadeh,et al. Density functional theory studies of oxygen and carbonate binding to a dicopper patellamide complex. , 2008, Journal of inorganic biochemistry.
[87] B. Bassler,et al. Quorum sensing in bacteria. , 2001, Annual review of microbiology.
[88] L. Dai,et al. Total synthesis and stereochemical revision of lagunamide A. , 2012, Chemical communications.
[89] Richard E. Moore,et al. Structurally diverse new alkaloids from Palauan collections of the apratoxin-producing marine cyanobacterium Lyngbya sp. ☆ , 2002 .
[90] Makoto Muroi,et al. Target identification of small molecules based on chemical biology approaches. , 2013, Molecular bioSystems.
[91] W. Gerwick,et al. Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. , 1999, Toxicon : official journal of the International Society on Toxinology.
[92] V. Paul,et al. Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry. , 2010, Environmental microbiology reports.
[93] K. Suenaga,et al. Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: isolation, structure determination, synthesis, and biological activity , 2004 .
[94] Vipin Chandra Kalia,et al. Quorum sensing inhibitors: an overview. , 2013, Biotechnology advances.
[95] W. Gerwick,et al. Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. , 2012, Chemistry & biology.
[96] D. Hughes. Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance , 2003, Nature Reviews Genetics.
[97] Richard E. Moore,et al. New apratoxins of marine cyanobacterial origin from Guam and Palau. , 2002, Bioorganic & medicinal chemistry.
[98] F. Koehn. Natural Products and Cancer Drug Discovery , 2013 .
[99] Ronald Breslow,et al. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug , 2007, Nature Biotechnology.
[100] J. Mccammon,et al. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. , 2014, Journal of natural products.
[101] Shin-ichi Sato,et al. Biochemical target isolation for novices: affinity-based strategies. , 2010, Chemistry & biology.
[102] M. Jordan,et al. Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.
[103] Péter Lénárt,et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo , 2007, Current Biology.
[104] P. Scheuer,et al. Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa. , 2004, Journal of natural products.
[105] M. Uesugi,et al. Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. , 2011, Chemistry & biology.
[106] B. Mellado,et al. A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer , 2004, International Journal of Gynecologic Cancer.
[107] Minoru Yoshida,et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. , 2002, Cancer research.
[108] L. Morris,et al. Conformational change in the thiazole and oxazoline containing cyclic octapeptides, the patellamides. Part 1. Cu2+ and Zn2+ induced conformational change , 2002 .
[109] C. Dumontet,et al. Microtubule-binding agents: a dynamic field of cancer therapeutics , 2010, Nature Reviews Drug Discovery.
[110] W. Gerwick,et al. Evolved Diversification of a Modular Natural Product Pathway: Apratoxins F and G, Two Cytotoxic Cyclic Depsipeptides from a Palmyra Collection of Lyngbya bouillonii , 2010, Chembiochem : a European journal of chemical biology.
[111] Brian C. Smith,et al. Chemical mechanisms of histone lysine and arginine modifications. , 2009, Biochimica et biophysica acta.
[112] P. Scheuer,et al. Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydnoides. , 2002, Journal of natural products.
[113] Hendrik Luesch,et al. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. , 2009, Journal of medicinal chemistry.
[114] Roger G Linington,et al. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. , 2010, Journal of medicinal chemistry.
[115] Jacques Ravel,et al. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians , 2006, Nature chemical biology.
[116] J. Clardy,et al. Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function. , 1994, Chemistry & biology.
[117] Bradley S Moore,et al. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. , 2012, Chemistry & biology.
[118] Hendrik Luesch,et al. Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity , 2011, ACS medicinal chemistry letters.
[119] Justin Lamb,et al. The Connectivity Map: a new tool for biomedical research , 2007, Nature Reviews Cancer.
[120] Peter G Schultz,et al. A functional genomics approach to the mode of action of apratoxin A , 2006, Nature chemical biology.
[121] Y. Li,et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy , 2009, The Journal of cell biology.
[122] Lilibeth A. Salvador,et al. Discovery and mechanism of natural products as modulators of histone acetylation. , 2012, Current drug targets.
[123] A. Kraft,et al. Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[124] M. Yoshida,et al. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. , 1998, Experimental cell research.
[125] V. Paul,et al. Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula. , 2000, Journal of natural products.
[126] H. Simon,et al. Cathepsins and their involvement in immune responses. , 2010, Swiss medical weekly.
[127] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[128] K D Paull,et al. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. , 1991, The Journal of biological chemistry.
[129] C. Crews,et al. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. , 2013, Natural product reports.
[130] G. Harrigan,et al. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. , 1998, Journal of natural products.
[131] R. Cerny,et al. Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia , 1989 .
[132] S. Saito. Toxins affecting actin filaments and microtubules. , 2009, Progress in molecular and subcellular biology.
[133] J. Mesirov,et al. Chemosensitivity prediction by transcriptional profiling , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[134] Sixue Chen,et al. Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms , 2013, Oncogene.
[135] P. Clemons,et al. Target identification and mechanism of action in chemical biology and drug discovery. , 2013, Nature chemical biology.
[136] V. Paul,et al. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. , 2013, Journal of medicinal chemistry.
[137] V. Paul,et al. Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. , 2011, Molecular bioSystems.
[138] Feng Cong,et al. Chemical genetics-based target identification in drug discovery. , 2012, Annual review of pharmacology and toxicology.
[139] P. Jensen,et al. Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A , 2007 .
[140] V. Israel,et al. Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer. , 2003, Lung cancer.
[141] Richard E. Moore,et al. Total structures of cryptophycins, potent antitumor depsipeptides from the blue-green alga Nostoc sp. strain GSV 224 , 1994 .
[142] V. Paul,et al. Grassypeptolides as Natural Inhibitors of Dipeptidyl Peptidase 8 and T‐Cell Activation , 2014, Chembiochem : a European journal of chemical biology.
[143] J. Cooper,et al. Effects of cytochalasin and phalloidin on actin , 1987, The Journal of cell biology.
[144] Erin E. Carlson,et al. Natural products as chemical probes. , 2010, ACS chemical biology.
[145] S. Schreiber,et al. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. , 2008, Journal of the American Chemical Society.
[146] Richard E. Moore,et al. Structure determination, conformational analysis, chemical stability studies, and antitumor evaluation of the cryptophycins. Isolation of 18 new analogs from Nostoc sp. strain GSV 224 , 1995 .
[147] M. Muda,et al. Model organisms and target discovery. , 2004, Drug discovery today. Technologies.
[148] Jonathan Puddick,et al. Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. , 2011, Phytochemistry.
[149] S. Schreiber,et al. Synthesis of Natural and Modified Trapoxins, Useful Reagents for Exploring Histone Deacetylase Function , 1996 .
[150] W. Gerwick,et al. Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[151] Hendrik Luesch,et al. Towards high-throughput characterization of small molecule mechanisms of action. , 2006, Molecular bioSystems.
[152] V. Paul,et al. Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. , 2013, Organic letters.
[153] W. Gerwick,et al. Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. , 2009, Chemistry & biology.
[154] T. Robak,et al. Depsipeptide (FK228) as a novel histone deacetylase inhibitor: mechanism of action and anticancer activity. , 2007, Mini reviews in medicinal chemistry.
[155] W. Gerwick,et al. Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. , 2006, Journal of natural products.
[156] Wei Zhang,et al. Total synthesis and stereochemical reassignment of tasiamide , 2008, Journal of peptide science : an official publication of the European Peptide Society.
[157] G. Harrigan,et al. Isolation, structure determination, and biological activity of dolastatin 12 and lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages. , 1998, Journal of natural products.
[158] D. Christianson,et al. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. , 2011, Journal of the American Chemical Society.
[159] Joachim Müller,et al. New approaches for the identification of drug targets in protozoan parasites. , 2013, International review of cell and molecular biology.
[160] S. Aoki,et al. ARENASTATIN A, A POTENT CYTOTOXIC DEPSIPEPTIDE FROM THE OKINAWAN MARINE SPONGE DYSIDEA ARENARIA , 1994 .
[161] K. Shin‐ya,et al. Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp. , 2001 .
[162] W. Gerwick,et al. Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula. , 2001, Journal of natural products.
[163] T. Molinski,et al. Symplocin A, a linear peptide from the Bahamian cyanobacterium Symploca sp. Configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters. , 2012, Journal of natural products.
[164] William H Gerwick,et al. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. , 2004, Chemistry & biology.
[165] J. Kwan,et al. Evaluation of class I HDAC isoform selectivity of largazole analogues. , 2014, Bioorganic & medicinal chemistry letters.
[166] S. Wilkinson,et al. Trypanocidal drugs: mechanisms, resistance and new targets , 2009, Expert Reviews in Molecular Medicine.
[167] Roger G. Linington,et al. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. , 2013, Journal of natural products.
[168] N. Schork,et al. Kinase mutations in human disease: interpreting genotype–phenotype relationships , 2010, Nature Reviews Genetics.
[169] Richard E. Moore,et al. Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. , 2002, Journal of natural products.
[170] P. Senter,et al. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma , 2012, Nature Biotechnology.
[171] W. Gerwick,et al. Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction. , 2012, Bioorganic & medicinal chemistry letters.
[172] Hendrik Luesch,et al. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. , 2008, Journal of the American Chemical Society.
[173] H. Osada,et al. Morphobase, an encyclopedic cell morphology database, and its use for drug target identification. , 2012, Chemistry & biology.
[174] W. Gerwick,et al. Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majuscula , 1995 .
[175] S. Friedman,et al. A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor‐β and vascular endothelial growth factor signalling , 2013, Liver international : official journal of the International Association for the Study of the Liver.
[176] E. Hamel,et al. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. , 1990, Biochemical pharmacology.
[177] H. Hansen,et al. Lung cancer. , 1990, Cancer chemotherapy and biological response modifiers.
[178] W. Gerwick,et al. Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. , 2009, Journal of Organic Chemistry.
[179] Richard E. Moore,et al. The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp. , 2003, Journal of natural products.
[180] K. Janda,et al. Total synthesis of the depsipeptide FR-901375. , 2003, The Journal of organic chemistry.
[181] G. Superti-Furga,et al. Target profiling of small molecules by chemical proteomics. , 2009, Nature chemical biology.
[182] Christian P. Ridley,et al. Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae. , 2005, Chemistry & biology.