Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

Over the last few decades, polymers have been extensively used as pharmaceutical excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply used as gelatin shells comprising capsule to offering great formulation advantages including enabling controlled/slow release and specific targeting of drugs to the site(s) of action (the “magic bullets” concept), hence hold a significant clinical promise.

[1]  J. Sunil Pharmaceutical Dosage Forms: Tablets. Vol. 1. , 1990 .

[2]  A. Dahan,et al.  Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility-Permeability Interplay. , 2015, Journal of pharmaceutical sciences.

[3]  Naveen Chella,et al.  Formulation and Pharmacokinetic Evaluation of Polymeric Dispersions Containing Valsartan , 2015, European Journal of Drug Metabolism and Pharmacokinetics.

[4]  J. Sousa,et al.  Role of Cellulose Ether Polymers on Ibuprofen Release from Matrix Tablets , 2005, Drug development and industrial pharmacy.

[5]  A. Lamprecht,et al.  Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation. , 2012, International journal of pharmaceutics.

[6]  M. Niemi,et al.  Membrane transporters in drug development , 2010, Nature Reviews Drug Discovery.

[7]  D. Law,et al.  Influence of solid phase and formulation processing on stability of Abbott-232 tablet formulations. , 2006, Journal of pharmaceutical sciences.

[8]  C M Ji,et al.  Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil , 2009, Journal of biomaterials applications.

[9]  H. Junginger,et al.  Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles , 1996 .

[10]  Shirui Mao,et al.  Elucidation of release characteristics of highly soluble drug trimetazidine hydrochloride from chitosan-carrageenan matrix tablets. , 2013, Journal of pharmaceutical sciences.

[11]  A. Dahan,et al.  Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[12]  S. B. Tiwari,et al.  Application of Ethylcellulose Coating to Hydrophilic Matrices: A Strategy to Modulate Drug Release Profile and Reduce Drug Release Variability , 2014, AAPS PharmSciTech.

[13]  G. Amidon,et al.  The solubility-permeability interplay: mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation. , 2011, Molecular pharmaceutics.

[14]  P. Nagadivya Effect of various binding agents on tablet hardness and release rate profiles of diclofenac sodium tablets , 2016 .

[15]  J. van Humbeeck,et al.  Crystallization Kinetics of Indomethacin/Polyethylene Glycol Dispersions Containing High Drug Loadings. , 2015, Molecular pharmaceutics.

[16]  S. Moghimi,et al.  Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective. , 2012, Maturitas.

[17]  R. Manzo,et al.  Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[18]  Han‐Gon Choi,et al.  Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change , 2011, Drug delivery.

[19]  I. Wilding,et al.  In Vitro and in Vivo Pharmacoscintigraphic Evaluation of Ibuprofen Hypromellose and Gelatin Capsules , 2004, Pharmaceutical Research.

[20]  A. Bernkop‐Schnürch,et al.  Thiolated polymers--thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. , 2003, International journal of pharmaceutics.

[21]  Margareth R. C. Marques Enzymes in the Dissolution Testing of Gelatin Capsules , 2014, AAPS PharmSciTech.

[22]  Hong Liu,et al.  Chitosan-based controlled porosity osmotic pump for colon-specific delivery system: screening of formulation variables and in vitro investigation. , 2007, International journal of pharmaceutics.

[23]  G. Amidon,et al.  Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir. , 2010, Molecular pharmaceutics.

[24]  Lawrence X. Yu,et al.  High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations. , 2010, Molecular pharmaceutics.

[25]  G. Amidon,et al.  Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[26]  Li Sheng,et al.  Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[27]  Changquan Calvin Sun,et al.  A formulation strategy for solving the overgranulation problem in high shear wet granulation. , 2014, Journal of pharmaceutical sciences.

[28]  S. Schwendeman,et al.  Development and In Vitro-In Vivo Evaluation of Fenretinide-Loaded Oral Mucoadhesive Patches for Site-Specific Chemoprevention of Oral Cancer , 2011, Pharmaceutical Research.

[29]  M. Aulton,et al.  Pharmaceutical Coating Technology , 1995 .

[30]  J. Crison,et al.  A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.

[31]  A. Dahan,et al.  The solubility-permeability interplay and oral drug formulation design: Two heads are better than one. , 2016, Advanced drug delivery reviews.

[32]  P. Ravaux,et al.  Enzymatically degraded Eurylon 6 HP‐PG: ethylcellulose film coatings for colon targeting in inflammatory bowel disease patients , 2010, The Journal of pharmacy and pharmacology.

[33]  H. Lieberman,et al.  Pharmaceutical dosage forms : tablets , 1980 .

[34]  A. Streubel,et al.  Understanding and Predicting Drug Delivery from Hydrophilic Matrix Tablets Using the “Sequential Layer” Model , 2002, Pharmaceutical Research.

[35]  C. Samyn,et al.  In Vivo Evaluation of a Colon-Specific Drug Delivery System: An Absorption Study of Theophylline from Capsules Coated with Azo Polymers in Rats , 1995, Pharmaceutical Research.

[36]  A. Dahan,et al.  The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs , 2012, The AAPS Journal.

[37]  P. Langguth,et al.  Oral Solid Dosage Form Disintegration Testing - The Forgotten Test. , 2015, Journal of pharmaceutical sciences.

[38]  Leslie Z. Benet,et al.  Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System , 2004, Pharmaceutical Research.

[39]  W. Roediger,et al.  Colonic bicarbonate output as a test of disease activity in ulcerative colitis. , 1984, Journal of clinical pathology.

[40]  L. S. Taylor,et al.  Phase separation kinetics in amorphous solid dispersions upon exposure to water. , 2015, Molecular pharmaceutics.

[41]  M. Z. Khan,et al.  A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation Of drug release using Eudragit L100-55 and Eudragit S100 combinations. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[42]  S. Itai,et al.  An easy-to-use approach for determining the disintegration ability of disintegrants by analysis of available surface area. , 2013, International journal of pharmaceutics.

[43]  P. Verma,et al.  Controlled Porosity Solubility Modulated Osmotic Pump Tablets of Gliclazide , 2014, AAPS PharmSciTech.

[44]  R. Löbenberg,et al.  Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[45]  G. Amidon,et al.  The fraction dose absorbed, in humans, and high jejunal human permeability relationship. , 2012, Molecular pharmaceutics.

[46]  S. A. Sande,et al.  Immersion coating of pellet cores consisting of chitosan and calcium intended for colon drug delivery. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[47]  L. Emara,et al.  Development of an osmotic pump system for controlled delivery of diclofenac sodium. , 2012, Drug discoveries & therapeutics.

[48]  J. Hardcastle,et al.  Measurement of gastrointestinal pH profiles in normal ambulant human subjects. , 1988, Gut.

[49]  Anders Axelsson,et al.  A model for the drug release from a polymer matrix tablet--effects of swelling and dissolution. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[50]  K. Takada,et al.  Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[51]  J. Remon,et al.  Effect of the Storage Conditions on the Tensile Strength of Tablets in Relation to the Enthalpy Relaxation of the Binder , 2000, Pharmaceutical Research.

[52]  John E. Hogan,et al.  Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets , 1987 .

[53]  A. Dahan,et al.  The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[54]  G. Amidon,et al.  Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update , 2010, Expert review of clinical immunology.

[55]  M S Gordon,et al.  Effect of the mode of super disintegrant incorporation on dissolution in wet granulated tablets. , 1993, Journal of pharmaceutical sciences.

[56]  M. A. Alhnan,et al.  A flexible-dose dispenser for immediate and extended release 3D printed tablets. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[57]  A. Dahan,et al.  Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations , 2013, PloS one.

[58]  Gordon L. Amidon,et al.  Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs , 2009, The AAPS Journal.

[59]  R. Davé,et al.  Enhanced physical stabilization of fenofibrate nanosuspensions via wet co-milling with a superdisintegrant and an adsorbing polymer. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[60]  A. Dahan,et al.  The interaction of nifedipine with selected cyclodextrins and the subsequent solubility-permeability trade-off. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[61]  S. Bloomfield,et al.  Investigations into the azo reducing activity of a common colonic microorganism , 1997 .

[62]  W. Hinrichs,et al.  Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[63]  Hassan Benameur,et al.  Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration. , 2008, Advanced drug delivery reviews.

[64]  G. W. Skinner,et al.  Investigating the fundamental effects of binders on pharmaceutical tablet performance. , 1999, Drug development and industrial pharmacy.

[65]  G. Stephenson,et al.  Assessment of the amorphous "solubility" of a group of diverse drugs using new experimental and theoretical approaches. , 2015, Molecular pharmaceutics.

[66]  O Bley,et al.  Characterization of moisture-protective polymer coatings using differential scanning calorimetry and dynamic vapor sorption. , 2009, Journal of pharmaceutical sciences.

[67]  M. Hussain,et al.  Mitigation of Adverse Clinical Events of a Narrow Target Therapeutic Index Compound through Modified Release Formulation Design: An in Vitro, in Vivo, in Silico, and Clinical Pharmacokinetic Analysis. , 2015, Molecular pharmaceutics.

[68]  R. Vivilecchia,et al.  Elimination of metformin-croscarmellose sodium interaction by competition. , 2006, International journal of pharmaceutics.

[69]  Sang-Min Cho,et al.  In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex. , 2013, International journal of pharmaceutics.

[70]  L. Emara,et al.  Controlled porosity osmotic pump system for the delivery of diclofenac sodium: in-vitro and in-vivo evaluation , 2014, Pharmaceutical development and technology.

[71]  H. Faghihian,et al.  Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions , 2006, Drug delivery.

[72]  Mrudula H. Bele,et al.  Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF , 2011, AAPS PharmSciTech.

[73]  A. Bernkop‐Schnürch,et al.  Development and in Vivo Evaluation of an Oral Delivery System for Low Molecular Weight Heparin Based on Thiolated Polycarbophil , 2003, Pharmaceutical Research.

[74]  W. Curatolo,et al.  Effects of Food on a Gastrically Degraded Drug: Azithromycin Fast-Dissolving Gelatin Capsules and HPMC Capsules , 2011, Pharmaceutical Research.

[75]  S. Jacob,et al.  Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin? , 2007, Interactive cardiovascular and thoracic surgery.

[76]  S. Mitragotri,et al.  Mucoadhesive intestinal devices for oral delivery of salmon calcitonin. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[77]  Kozo Takayama,et al.  Evaluation of the disintegration time of rapidly disintegrating tablets via a novel method utilizing a CCD camera. , 2002, Chemical & pharmaceutical bulletin.

[78]  K Thoma,et al.  Influence of aqueous coatings on the stability of enteric coated pellets and tablets. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[79]  Y. Nishiyama,et al.  Dry coating: an innovative enteric coating method using a cellulose derivative. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[80]  J. Gallo,et al.  A Simple Rheological Method for the in Vitro Assessment of Mucin-Polymer Bioadhesive Bond Strength , 1990, Pharmaceutical Research.

[81]  D. Neckers,et al.  A new approach to the oral administration of insulin and other peptide drugs. , 1986, Science.

[82]  G. Amidon,et al.  Physiological parameters for oral delivery and in vitro testing. , 2010, Molecular pharmaceutics.

[83]  S. Mathew,et al.  Mucoadhesive patches of Salbutamol sulphate for unidirectional buccal drug delivery: development and evaluation. , 2011, Current drug delivery.

[84]  E. Taha,et al.  A new pressure-controlled colon delivery capsule for chronotherapeutic treatment of nocturnal asthma , 2011, Journal of drug targeting.

[85]  I. Wilding,et al.  Enteric coated HPMC capsules designed to achieve intestinal targeting. , 2002, International journal of pharmaceutics.

[86]  J. Mcginity,et al.  Relationship of film properties to drug release from monolithic films containing adjuvants. , 1992, Journal of pharmaceutical sciences.

[87]  Smita Raghuvanshi,et al.  Oral Bioavailability: Issues and Solutions via Nanoformulations , 2015, Clinical Pharmacokinetics.

[88]  J. Misiewicz,et al.  Increased segmental activity and intraluminal pressures in the sigmoid colon of patients with the irritable bowel syndrome. , 1989, Gut.

[89]  He Wei,et al.  Pectin/Ethylcellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets. , 2007, PDA journal of pharmaceutical science and technology.

[90]  Viktoriya Ioffe-Dahan,et al.  The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane , 2012, The AAPS Journal.

[91]  Kinam Park Drug release mechanisms from amorphous solid dispersions. , 2015, Journal of Controlled Release.

[92]  N. Urbanetz Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[93]  R. Rowe Handbook of Pharmaceutical Excipients – 7th Edition , 2013 .

[94]  W. Lowenthal,et al.  Mechanism of action of starch as a tablet disintegrant IV: effect of medicaments and disintegrants on mean pore diameter and porosity. , 1971, Journal of pharmaceutical sciences.

[95]  W. Weitschies,et al.  Development of pressure-sensitive dosage forms with a core liquefying at body temperature. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[96]  S. Ben-Shabat,et al.  Modern Prodrug Design for Targeted Oral Drug Delivery , 2014, Molecules.

[97]  S. Travis,et al.  Once-daily budesonide MMX in active, mild-to-moderate ulcerative colitis: results from the randomised CORE II study , 2013, Gut.

[98]  J. Siepmann,et al.  Characterization of ethylcellulose: starch-based film coatings for colon targeting , 2009, Drug development and industrial pharmacy.

[99]  Celine Valeria Liew,et al.  Distribution of a viscous binder during high shear granulation--sensitivity to the method of delivery and its impact on product properties. , 2014, International journal of pharmaceutics.

[100]  M. Grimm,et al.  Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System. , 2015, Journal of pharmaceutical sciences.

[101]  Mohammed Maniruzzaman,et al.  Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. , 2011, Colloids and surfaces. B, Biointerfaces.

[102]  C. Neut,et al.  Novel polymeric film coatings for colon targeting: how to adjust desired membrane properties. , 2009, International journal of pharmaceutics.

[103]  A. Dahan,et al.  The use of captisol (SBE7-β-CD) in oral solubility-enabling formulations: Comparison to HPβCD and the solubility-permeability interplay. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[104]  S. Majumdar,et al.  The effects of screw configuration and polymeric carriers on hot-melt extruded taste-masked formulations incorporated into orally disintegrating tablets. , 2015, Journal of pharmaceutical sciences.

[105]  G. Alderborn,et al.  Moisture adsorption and tabletting. III. Effect on tablet strenght-post compaction storage time profiles , 1991 .

[106]  P. Schmidt,et al.  Fast dispersible ibuprofen tablets. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[107]  D. Attwood,et al.  An in vivo investigation into the suitability of pH dependent polymers for colonic targeting , 1993 .

[108]  P. Artursson,et al.  Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement , 1997, Pharmaceutical Research.

[109]  Jianing Zeng,et al.  Development of oral extended release formulations of 6‐hydroxybuspirone , 2012, Biopharmaceutics & drug disposition.

[110]  W. Lowenthal Mechanism of action of tablet disintegrants: correlation of tablet mean pore diameter and porosity. , 1972, Journal of pharmaceutical sciences.

[111]  F. Prüfert,et al.  Synthesis and in vitro characterization of a novel S-protected thiolated alginate. , 2015, Carbohydrate polymers.

[112]  T. Reineke,et al.  Dissolution and Solubility Enhancement of the Highly Lipophilic Drug Phenytoin via Interaction with Poly(N-isopropylacrylamide-co-vinylpyrrolidone) Excipients. , 2015, Molecular pharmaceutics.

[113]  M. K. Chourasia,et al.  Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: strategies and industrial perspectives. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[114]  F Theeuwes,et al.  Elementary osmotic pump. , 1975, Journal of pharmaceutical sciences.

[115]  T De Beer,et al.  Stability and repeatability of a continuous twin screw granulation and drying system. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[116]  A. Bernkop‐Schnürch,et al.  Thiolated silicone oil: Synthesis, gelling and mucoadhesive properties , 2015, Acta biomaterialia.

[117]  Omri Wolk,et al.  New targeting strategies in drug therapy of inflammatory bowel disease: mechanistic approaches and opportunities , 2013, Expert opinion on drug delivery.

[118]  A. Dahan,et al.  Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model validation. , 2012, International journal of pharmaceutics.

[119]  A. Larsson,et al.  Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[120]  J. Hardy,et al.  Evaluation of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet in patients with inflammatory bowel disease , 1987, Alimentary pharmacology & therapeutics.

[121]  K. Takada,et al.  Importance of dissolution process on systemic availability of drugs delivered by colon delivery system. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[122]  Hydrogen bond replacement--unearthing a novel molecular mechanism of surface solid dispersion for enhanced solubility of a drug for veterinary use. , 2013, International journal of pharmaceutics.

[123]  Leslie Z Benet,et al.  Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. , 2008, Advanced drug delivery reviews.

[124]  J. Dressman,et al.  Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women , 1990, Pharmaceutical Research.

[125]  A. Basit,et al.  Accelerating the dissolution of enteric coatings in the upper small intestine: evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release. , 2014, International journal of pharmaceutics.

[126]  Ping I. Lee,et al.  Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[127]  Gordon L Amidon,et al.  A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals , 2002, Journal of clinical pharmacology.

[128]  Matteo Cerea,et al.  A novel powder coating process for attaining taste masking and moisture protective films applied to tablets. , 2004, International journal of pharmaceutics.

[129]  J. Siepmann,et al.  Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets , 2003, Drug development and industrial pharmacy.

[130]  S. P. Jones Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs. , 1996, Journal of drug targeting.

[131]  Arik Dahan,et al.  A win-win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability. , 2012, Molecular pharmaceutics.

[132]  M S Gordon,et al.  Effect of formulation solubility and hygroscopicity on disintegrant efficiency in tablets prepared by wet granulation, in terms of dissolution. , 1991, Journal of pharmaceutical sciences.

[133]  A. Dahan,et al.  Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine , 2013, The AAPS Journal.

[134]  A. Rajabi-Siahboomi,et al.  Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[135]  L. Augsburger,et al.  Multiple tamping effects on drug dissolution from capsules filled on a dosing-disk type automatic capsule filling machine. , 1987, Journal of pharmaceutical sciences.

[136]  C. Leopold,et al.  Basic Coating Polymers for the Colon-Specific Drug Delivery in Inflammatory Bowel Disease , 2000, Drug development and industrial pharmacy.

[137]  A. Dahan,et al.  The solubility-permeability interplay when using cosolvents for solubilization: revising the way we use solubility-enabling formulations. , 2012, Molecular pharmaceutics.

[138]  J. Folkman,et al.  THE USE OF SILICONE RUBBER AS A CARRIER FOR PROLONGED DRUG THERAPY. , 1964, The Journal of surgical research.

[139]  L. Lachman Physical and chemical stability testing of tablet dosage forms. , 1965, Journal of pharmaceutical sciences.

[140]  V. Shah,et al.  Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance. , 1994, Journal of pharmaceutical sciences.

[141]  A. Ohike,et al.  Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[142]  E Shotton,et al.  Effect of intragranular and extragranular disintegrating agents on particle size of disintegrated tablets. , 1976, Journal of pharmaceutical sciences.

[143]  C. Samyn,et al.  The Relation Between Swelling Properties and Enzymatic Degradation of Azo Polymers Designed for Colon-Specific Drug Delivery , 1994, Pharmaceutical Research.

[144]  S. I. Kim,et al.  Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behavior, and utilization for drug formulation. , 2000, Journal of controlled release : official journal of the Controlled Release Society.