Lethal mutagenesis: targeting the mutator phenotype in cancer.

[1]  C. Cazaux,et al.  Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer. , 2010, Seminars in cancer biology.

[2]  R. Beckman Efficiency of carcinogenesis: is the mutator phenotype inevitable? , 2010, Seminars in cancer biology.

[3]  M. Horwitz,et al.  Passenger mutations as a marker of clonal cell lineages in emerging neoplasia. , 2010, Seminars in cancer biology.

[4]  L. Loeb,et al.  The mutator phenotype in cancer: molecular mechanisms and targeting strategies. , 2010, Current drug targets.

[5]  E. Domingo,et al.  A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape , 2010, PLoS pathogens.

[6]  A. Thompson,et al.  DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability , 2010, Proceedings of the National Academy of Sciences.

[7]  A. Sparks,et al.  The mutation spectrum revealed by paired genome sequences from a lung cancer patient , 2010, Nature.

[8]  Elias Campo Guerri,et al.  International network of cancer genome projects , 2010, Nature.

[9]  Joshua F. McMichael,et al.  Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft , 2010, Nature.

[10]  Gary D Bader,et al.  International network of cancer genome projects , 2010, Nature.

[11]  L. Malinina,et al.  Mechanism of error-free and semi-targeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4 , 2010, Nature Structural &Molecular Biology.

[12]  E. Birney,et al.  A small cell lung cancer genome reports complex tobacco exposure signatures , 2009, Nature.

[13]  Tom Royce,et al.  A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.

[14]  Alan F. Rubin,et al.  Mutation patterns in cancer genomes , 2009, Proceedings of the National Academy of Sciences.

[15]  M. Bronner,et al.  Clonal expansions in ulcerative colitis identify patients with neoplasia , 2009, Proceedings of the National Academy of Sciences.

[16]  Ken Chen,et al.  Recurring mutations found by sequencing an acute myeloid leukemia genome. , 2009, The New England journal of medicine.

[17]  L. M. Mansky,et al.  5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1 , 2009, Journal of Virology.

[18]  M. Eigen,et al.  The Hypercycle: A principle of natural self-organization , 2009 .

[19]  Jesse J Salk,et al.  Cancer genome sequencing--an interim analysis. , 2009, Cancer research.

[20]  Amy E. Hawkins,et al.  DNA sequencing of a cytogenetically normal acute myeloid leukemia genome , 2008, Nature.

[21]  Claus O Wilke,et al.  Lethal Mutagenesis of Bacteria , 2008, Genetics.

[22]  Brian H. Dunford-Shore,et al.  Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.

[23]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[24]  Joshua M. Korn,et al.  Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2008, Nature.

[25]  Robert A Beckman,et al.  Cancers exhibit a mutator phenotype: clinical implications. , 2008, Cancer research.

[26]  Blake R. Peterson,et al.  Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues , 2008, Antimicrobial Agents and Chemotherapy.

[27]  A. Sparks,et al.  The Genomic Landscapes of Human Breast and Colorectal Cancers , 2007, Science.

[28]  C. Cameron,et al.  Synthesis of a Universal 5‐Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA‐Dependent RNA Polymerase , 2007, Chembiochem : a European journal of chemical biology.

[29]  D. Lin,et al.  Fen1 mutations result in autoimmunity, chronic inflammation and cancers , 2007, Nature Medicine.

[30]  E. Birney,et al.  Patterns of somatic mutation in human cancer genomes , 2007, Nature.

[31]  V. Lohmann,et al.  Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. , 2007, Gastroenterology.

[32]  E. Domingo,et al.  Foot-and-Mouth Disease Virus Mutant with Decreased Sensitivity to Ribavirin: Implications for Error Catastrophe , 2006, Journal of Virology.

[33]  Lawrence D True,et al.  Human cancers express a mutator phenotype , 2006, Proceedings of the National Academy of Sciences.

[34]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[35]  R. Montesano,et al.  Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa. , 2006, Carcinogenesis.

[36]  S. Akman,et al.  Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli. , 2006, Mutation research.

[37]  M. Vignuzzi,et al.  Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population , 2006, Nature.

[38]  Michael Lachmann,et al.  Quasispecies Made Simple , 2005, PLoS Comput. Biol..

[39]  T. Skopek,et al.  5-fluorouracil forward mutation assay in Salmonella: determination of mutational target and spontaneous mutational spectra. , 2005, Mutation research.

[40]  J. Hoofnagle,et al.  Mechanism of action of interferon and ribavirin in treatment of hepatitis C , 2005, Nature.

[41]  E. Domingo,et al.  Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection. , 2005, Virology.

[42]  A. Gall,et al.  KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. , 2005, Antiviral research.

[43]  L. Loeb,et al.  Lethal mutagenesis of HIV. , 2005, Virus research.

[44]  Donna Neuberg,et al.  Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. , 2005, Cancer cell.

[45]  L. Loeb,et al.  Environmental and chemical carcinogenesis. , 2004, Seminars in cancer biology.

[46]  L. Loeb,et al.  Viral error catastrophe by mutagenic nucleosides. , 2004, Annual review of microbiology.

[47]  Ping Chen,et al.  Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor , 2004, Science.

[48]  A. Hochhaus,et al.  Clinical resistance to imatinib: mechanisms and implications. , 2004, Hematology/oncology clinics of North America.

[49]  Ricard V Solé,et al.  An error catastrophe in cancer? , 2004, Journal of theoretical biology.

[50]  Thomas B. Kepler,et al.  Unselected Mutations in the Human Immunodeficiency Virus Type 1 Genome Are Mostly Nonsynonymous and Often Deleterious , 2004, Journal of Virology.

[51]  M. King,et al.  Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 , 2003, Science.

[52]  Valeria Souza,et al.  Stress-Induced Mutagenesis in Bacteria , 2003, Science.

[53]  E. Domingo,et al.  Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). , 2003, Virology.

[54]  K. Loeb,et al.  Multiple mutations and cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  C. Ulrich,et al.  Polymorphisms in DNA repair genes and associations with cancer risk. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[56]  Manfred Eigen,et al.  Error catastrophe and antiviral strategy , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Alison L. Livingston,et al.  Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors , 2002, Nature Genetics.

[58]  X. Lin,et al.  Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair. , 2001, Cancer research.

[59]  Justin C. Fay,et al.  Positive and negative selection on the human genome. , 2001, Genetics.

[60]  C. Cameron,et al.  RNA virus error catastrophe: Direct molecular test by using ribavirin , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[61]  J. Arnold,et al.  The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen , 2000, Nature Network Boston.

[62]  F. Pedersen,et al.  Genetic reassortment and patch repair by recombination in retroviruses. , 2000, Journal of biomedical science.

[63]  N. Petrelli,et al.  The onset and extent of genomic instability in sporadic colorectal tumor progression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[64]  T. Lindahl,et al.  Quality control by DNA repair. , 1999, Science.

[65]  K. Kinzler,et al.  Genetic instability and darwinian selection in tumours. , 1999, Trends in cell biology.

[66]  J. Drake,et al.  Mutation rates among RNA viruses. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays , 1999, Nature Genetics.

[68]  P. Jeggo,et al.  Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient , 1999, Current Biology.

[69]  F. Hanaoka,et al.  Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity , 1999, The EMBO journal.

[70]  J. Drake,et al.  The Distribution of Rates of Spontaneous Mutation over Viruses, Prokaryotes, and Eukaryotes , 1999, Annals of the New York Academy of Sciences.

[71]  M. Speicher,et al.  Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[72]  C. McMurray,et al.  DNA secondary structure: a common and causative factor for expansion in human disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[73]  J. Mullins,et al.  Lethal mutagenesis of HIV with mutagenic nucleoside analogs. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[74]  J. Rüschoff,et al.  Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. , 1997, Cancer research.

[75]  D. Ledbetter,et al.  Multicolor Spectral Karyotyping of Human Chromosomes , 1996, Science.

[76]  Sajeev P. Cherian,et al.  Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. , 1996, Cancer research.

[77]  J. Coffin,et al.  HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy , 1995, Science.

[78]  A. Perelson,et al.  Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection , 1995, Nature.

[79]  S. Gould The evolution of life on the earth. , 1994, Scientific American.

[80]  Bert Vogelstein,et al.  Hypermutability and mismatch repair deficiency in RER+ tumor cells , 1993, Cell.

[81]  N. Copeland,et al.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer , 1993, Cell.

[82]  P. Schuster RNA based evolutionary optimization , 1993, Origins of life and evolution of the biosphere.

[83]  M. Eigen,et al.  Viral quasispecies. , 1993, Scientific American.

[84]  H. Maki,et al.  Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[85]  L. Loeb,et al.  Mutator phenotype may be required for multistage carcinogenesis. , 1991, Cancer research.

[86]  W. Blattner,et al.  Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome , 1990, Nature.

[87]  L. Strong,et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.

[88]  David A. Steinhauer,et al.  Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis , 1990, Journal of virology.

[89]  V. Pathak,et al.  Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[90]  P. Landrigan,et al.  Occupationally related disorders. , 1990, The Medical clinics of North America.

[91]  D. Richman,et al.  HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. , 1989, Science.

[92]  C. Hardy,et al.  Prostate cancer: a model of cancer in the elderly. , 1989, Archives of gerontology and geriatrics.

[93]  L. Loeb,et al.  Fidelity of HIV-1 reverse transcriptase. , 1988, Science.

[94]  T. Skopek,et al.  Rate of induced forward mutation at 3 genetic loci in Salmonella typhimurium. , 1983, Mutation research.

[95]  Lu-Yu Hwang,et al.  HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS A Prospective Study of 22 707 Men in Taiwan , 1981, The Lancet.

[96]  H. Varmus,et al.  Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites , 1978, Cell.

[97]  Charles Weissmann,et al.  Nucleotide sequence heterogeneity of an RNA phage population , 1978, Cell.

[98]  M. Eigen,et al.  The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. , 1977, Die Naturwissenschaften.

[99]  P. Nowell The clonal evolution of tumor cell populations. , 1976, Science.

[100]  J. Phair,et al.  Antiviral, immunosuppressive and antitumour effects of Ribavirin , 1976, Nature.

[101]  L. Loeb,et al.  Errors in DNA replication as a basis of malignant changes. , 1974, Cancer research.

[102]  M. Eigen Selforganization of matter and the evolution of biological macromolecules , 1971, Naturwissenschaften.

[103]  J. Cleaver Defective Repair Replication of DNA in Xeroderma Pigmentosum , 1968, Nature.

[104]  R. Goldschmidt,et al.  On Spontaneous Mutation. , 1944, Proceedings of the National Academy of Sciences of the United States of America.

[105]  D. Hansemann Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung , 1890, Archiv für pathologische Anatomie und Physiologie und für klinische Medicin.

[106]  E. Friedberg,et al.  DNA Repair and Mutagenesis , 2006 .

[107]  E. Domingo,et al.  Foot-and-Mouth Disease Virus Evolution: Exploring Pathways Towards Virus Extinction , 2005, Current topics in microbiology and immunology.

[108]  J. Mullins,et al.  Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs. , 2000, AIDS research and human retroviruses.

[109]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy-number changes using cDNA microarrays , 1999 .

[110]  Elias S. J. Arnér,et al.  Mammalian deoxyribonucleoside kinases. , 1995, Pharmacology & therapeutics.

[111]  B. Larder,et al.  The clinical significance of antiviral drug resistance. , 1992, Research in virology.

[112]  P. Reichard,et al.  Interactions between deoxyribonucleotide and DNA synthesis. , 1988, Annual review of biochemistry.

[113]  J. Holland,et al.  Rapid evolution of RNA viruses. , 1987, Annual review of microbiology.

[114]  E. Domingo,et al.  The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review. , 1985, Gene.

[115]  M. Eigen,et al.  Elementary step dynamics of catalytic hypercycles. , 1980, Bio Systems.

[116]  P. Shannon,et al.  Supporting Online Material Materials and Methods Som Text Figs. S1 to S9 Tables S1 to S17 References Dataset S1 Analysis of Genetic Inheritance in a Family Quartet by Whole-genome Sequencing , 2022 .