Alginate Application for Heart and Cardiovascular Diseases

Alginate biomaterial has been extensively investigated and used for many biomedical applications due to its biocompatibility, low toxicity, relatively low cost, and ease of use. Its use toward cardiovascular application is no exception. Alginate is approved by the Food and Drug Administration (FDA) for various medical applications, such as a thickening, gel forming, and as a stabilizing agent for dental impression materials, wound dressings, and more. In this chapter, we describe the versatile biomedical applications of alginate, from its use as supporting extracellular matrices (ECM) in patients after acute myocardial infarction (MI), to its employment as a vehicle for stem cell delivery, to controlled delivery of multiple combinations of bioactive molecules. We also cover the application of alginate in creating solutions for treatment of other cardiovascular diseases by capitalizing on the natural properties of alginate to improve creation of heart valves, blood vessels, and drug and stem cell delivery vehicles.

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