Some Properties of an Antiplasmin Substance from Rabbit Platelets

Summary Rabbit platelets contained a proteinase inhibitor which inhibited plasmin, trypsin and chymotrypsin activities, and serum kallikrein to some extent. It did not inhibit pancreatic kallikrein and thrombin. It reacted stoechiometrically with these enzymes in a prompt fashion and was found to have a molecular weight of about 40,000.

[1]  T. Suzuki,et al.  Purification and properties of bovine serum kallikrein activated with casein. , 1970, Journal of biochemistry.

[2]  S. Nagasawa,et al.  A simple method for purification of bovine plasminogen. , 1969, Journal of biochemistry.

[3]  J. Mcdonagh,et al.  Factor 13 and antiplasmin activity in human platelets. , 1969, The American journal of physiology.

[4]  L. Ehrenberg,et al.  Interaction of Plasmin and Trypsin with alpha2-Macroglobulin. , 1967 .

[5]  E. Mertz,et al.  Studies on plasminogen. V. Purification of bovine and human plasminogens by sephadex chromatography. , 1966, Canadian journal of biochemistry.

[6]  L. Lorand,et al.  ACTIVATION OF THE FIBRIN STABILIZING FACTOR OF PLASMA BY THROMBIN. , 1964, Archives of biochemistry and biophysics.

[7]  J. Whitaker.  Determination of Molecular Weights of Proteins by Gel Filtration of Sephadex. , 1963 .

[8]  W. Berg,et al.  Separation of Human Fibrinogen and Plasminogen by means of Gel Filtration , 1963, Thrombosis and Haemostasis.

[9]  H. Edmondson,et al.  Protein binding of pancreatic proteolytic enzymes. , 1962, The Journal of clinical investigation.

[10]  C. J. Martin.  Inhibition of trypsin, chymotrypsin, and plasmin by an inhibitor isolated from sheep serum. , 1962, The Journal of biological chemistry.

[11]  R. Holemans,et al.  Influence of Blood Platelets on Fibrinolysis , 1961, Thrombosis and Haemostasis.

[12]  F. Wu,et al.  Crystalline acid-labile trypsin inhibitor from bovine blood plasma. , 1960, The Journal of biological chemistry.

[13]  P. S. Roberts.  Measurement of the rate of plasmin action on synthetic substrates. , 1958, The Journal of biological chemistry.

[14]  S. Sherry,et al.  Studies on the Fibrinolytic Enzyme of Human Plasma) , 1957, Thrombosis and Haemostasis.

[15]  M. Stefanini,et al.  Studies on platelets. XIV. Human platelets as source of antifibrinolysin. , 1956, The Journal of clinical investigation.

[16]  S. Johnson,et al.  The existence of antifibrinolysin activity in platelets. , 1953, Science.

[17]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[18]  P. Cohen,et al.  Partial purification and properties of a proteolytic enzyme of human serum. , 1949, The Journal of biological chemistry.