Dual-modal photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

We report the development of a combined dual-modal photoacoustic and optical coherence tomography (PA-OCT) system using a single near-infrared (NIR) supercontinuum laser source which can provide both optical absorption and scattering contrasts simultaneously. By using a small sized pulsed Nd:YAG microchip laser and a photonic crystal fiber, we fabricated a pulsed broadband supercontinuum source from 600 to 1700 nm. Under the same optical hardware system, intrinsically registered PA and OCT images are acquired in a single scanning. In order to demonstrate feasibility of our system, we successfully acquired the PA and OCT images of black and white hairs images at the same time. The black hair was detected in both PA and OCT images, while the white hair appeared only in the OCT image. This result suggests the potential of compact, cost-effective, and simple dual-modal PA-OCT system. Moreover, we believe that this approach will be a key point for commercialization and clinical translation.

[1]  Yazan N. Billeh,et al.  Spectroscopic photoacoustic microscopy using a photonic crystal fiber supercontinuum source. , 2010, Optics express.

[2]  Ines Joekes,et al.  Hair color changes and protein damage caused by ultraviolet radiation. , 2004, Journal of photochemistry and photobiology. B, Biology.

[3]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[4]  Yu Wang,et al.  Integrated Photoacoustic and Fluorescence Confocal Microscopy , 2010, IEEE Transactions on Biomedical Engineering.

[5]  Jeehyun Kim,et al.  Full-range k-domain linearization in spectral-domain optical coherence tomography. , 2011, Applied optics.

[6]  Chulhong Kim,et al.  Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats--volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging. , 2010, Radiology.

[7]  Lihong V. Wang,et al.  Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. , 2008, Optics letters.

[8]  Qifa Zhou,et al.  Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization , 2011, Biomedical optics express.

[9]  Shuliang Jiao,et al.  Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform. , 2012, Journal of biomedical optics.

[10]  Lihong V. Wang,et al.  Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging , 2006, Nature Biotechnology.

[11]  W. Drexler,et al.  Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging , 2011, Biomedical optics express.

[12]  Geng Ku,et al.  Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies. , 2009, Optics express.

[13]  Shuliang Jiao,et al.  Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source. , 2012, Journal of biomedical optics.

[14]  Xin Cai,et al.  Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. , 2011, ACS nano.

[15]  P. Russell,et al.  Supercontinuum and four-wave mixing with Q-switched pulses in endlessly single-mode photonic crystal fibres. , 2004, Optics express.

[16]  Zhixing Xie,et al.  Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography. , 2009, Optics letters.