Food as a Hormone

Nutrient substrates derived from food can activate intracellular signaling cascades to regulate metabolic health. Diet has an enormous impact on many aspects of our health, yet scientific consensus about how what we eat affects our biology remains elusive. This is especially true with respect to the ongoing debate about obesity. While many in the scientific community focus on how high-fat diets can lead to increased body weight (1), others assert that we should blame processed carbohydrates (2). Is it possible that this focus on macronutrients (i.e., fats, proteins, and sugars) is misplaced?

[1]  S. Watkins,et al.  GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects , 2010, Cell.

[2]  G. Thomas,et al.  The amino acid sensitive TOR pathway from yeast to mammals , 2006, FEBS letters.

[3]  S. Woods,et al.  Acylation type determines ghrelin's effects on energy homeostasis in rodents. , 2012, Endocrinology.

[4]  V. Tremaroli,et al.  Functional interactions between the gut microbiota and host metabolism , 2012, Nature.

[5]  J. Buckley,et al.  Long-Chain Omega-3 Polyunsaturated Fatty Acids May Be Beneficial for Reducing Obesity—A Review , 2010, Nutrients.

[6]  J. Ashby References and Notes , 1999 .

[7]  S. Woods,et al.  A role for CNS PPARγ in the regulation of energy balance , 2011, Nature Medicine.

[8]  J. Olefsky,et al.  Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones , 2011, Nature Medicine.

[9]  P. Pfluger,et al.  GOAT links dietary lipids with the endocrine control of energy balance , 2009, Nature Medicine.

[10]  George Thomas,et al.  Hypothalamic mTOR Signaling Regulates Food Intake , 2006, Science.

[11]  S. Woods,et al.  Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. , 2012, Cell metabolism.

[12]  L. Schmidt,et al.  Public health: The toxic truth about sugar , 2012, Nature.

[13]  Hiraku Ono,et al.  Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. , 2008, Cell metabolism.

[14]  A. M. Habib,et al.  Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 , 2012, Diabetes.

[15]  M. Dietrich,et al.  Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity , 2011, Nature Medicine.

[16]  P. Elliott,et al.  Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human , 2012, Nature.