Local Cytokine Expression in Steroid‐Modified Tinea Faciei

In tinea faciei, a dermatophyte infection of the face, early stage lesions show erythema with crust and/or vesicles, a condition often misdiagnosed as dermatitis. Steroid application retards the healing in some cases and may induce penetration of the dermatophyte hyphae into hair and hair follicles. In the present study, we examined local immunity mediated by cytokines derived from lesional T lymphocytes in late stage of this disease. Interferon‐gamma (IFN‐γ) and macrophage migration inhibitory factor (MIF) were highly expressed, but neither interleukin‐4 (IL‐4) nor interleukin‐5 (IL‐5) could be detected by RT‐PCR using cryosections. These data suggested that IFN‐γ and MIF may be important in the delayed‐type hypersensitivity (DTH) response against the fungus in the hair follicle in late stages.

[1]  K. Katsuoka,et al.  Conversion of the CD4+ T cell profile from T(H2)-dominant type to T(H1)-dominant type after varicella-zoster virus infection in atopic dermatitis. , 1997, The Journal of allergy and clinical immunology.

[2]  K. Katsuoka,et al.  Local expression of IFN-γ mRNA in skin lesions of patients with dermatophytosis , 1996 .

[3]  J. Bernhagen,et al.  An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction , 1996, The Journal of experimental medicine.

[4]  J. Kim,et al.  Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. , 1995, Journal of immunology.

[5]  H. Ishizaki,et al.  In vitro release of intederon‐γ by peripheral blood mononuclear cells of patients with dermalophytosis in response to stimulation with trichophytin , 1993, The British journal of dermatology.

[6]  W. Sterry,et al.  Immunophenotypical characterization of inflammatory cellular infiltrates in tinea. , 1992, Acta dermato-venereologica.

[7]  K. Weinberg,et al.  Defining protective responses to pathogens: cytokine profiles in leprosy lesions. , 1991, Science.

[8]  A. Sher,et al.  Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells , 1991, Immunological reviews.

[9]  T. Mosmann,et al.  The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones. , 1989, Journal of immunology.

[10]  H. Tagami,et al.  Inflammation and immunity in dermatophytosis. , 1989, Dermatologica.

[11]  R. Calderón,et al.  Immunoregulation of dermatophytosis. , 1989, Critical reviews in microbiology.

[12]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[13]  J. Ingram.  Mycology , 1949 .