In silico models of M. tuberculosis infection provide a route to new therapies.
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[1] M. Fallahi-Sichani,et al. NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis , 2012, Front. Physio..
[2] Simeone Marino,et al. Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation , 2011, The Journal of Immunology.
[3] D. Kirschner,et al. A methodology for performing global uncertainty and sensitivity analysis in systems biology. , 2008, Journal of theoretical biology.
[4] Nagasuma Chandra,et al. Modeling metabolic adjustment in Mycobacterium tuberculosis upon treatment with isoniazid , 2010, Systems and Synthetic Biology.
[5] J. Medina-Franco,et al. Shifting from the single to the multitarget paradigm in drug discovery. , 2013, Drug discovery today.
[6] S. Klamt,et al. GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism , 2007, Genome Biology.
[7] Brendan Prideaux,et al. High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions. , 2011, Analytical chemistry.
[8] JoAnne L. Flynn,et al. Understanding Latent Tuberculosis: A Moving Target , 2010, The Journal of Immunology.
[9] G. Rook,et al. Immunotherapeutics for tuberculosis in experimental animals: is there a common pathway activated by effective protocols? , 2007, The Journal of infectious diseases.
[10] J. Christian J. Ray,et al. Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection1 , 2009, The Journal of Immunology.
[11] Jaques Reifman,et al. Modeling Phenotypic Metabolic Adaptations of Mycobacterium tuberculosis H37Rv under Hypoxia , 2012, PLoS Comput. Biol..
[12] Simeone Marino,et al. A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis , 2013 .
[13] JoAnne L. Flynn,et al. Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing , 2013, Nature Medicine.
[14] Wolfgang Wiechert,et al. 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis , 2013, Chemistry & biology.
[15] L. Schlesinger,et al. Mini Review Article , 2022 .
[16] S. Noack,et al. 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation , 2011, PLoS pathogens.
[17] Bruce R. Levin,et al. Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum , 2012, PLoS pathogens.
[18] W. Garira,et al. MATHEMATICAL MODELING OF CHEMOTHERAPY OF HUMAN TB INFECTION , 2006 .
[19] Denise E. Kirschner,et al. Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection , 2013, PloS one.
[20] Mohammad Fallahi-Sichani,et al. Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability , 2012, The Journal of Immunology.
[21] Steven Edward Kern,et al. Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions , 2011, Antimicrobial Agents and Chemotherapy.
[22] A. Myers,et al. Early Events in Mycobacterium tuberculosis Infection in Cynomolgus Macaques , 2006, Infection and Immunity.
[23] J. Flynn,et al. Macrophages and control of granulomatous inflammation in tuberculosis , 2011, Mucosal Immunology.
[24] R. Jelliffe,et al. Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs , 2009, Antimicrobial Agents and Chemotherapy.
[25] R. Wallis. Reconsidering adjuvant immunotherapy for tuberculosis. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[26] Jaques Reifman,et al. A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis , 2009, BMC Systems Biology.
[27] Alimuddin Zumla,et al. Advances in the development of new tuberculosis drugs and treatment regimens , 2013, Nature Reviews Drug Discovery.
[28] D. Kirschner,et al. Contribution of CD8+ T Cells to Control of Mycobacterium tuberculosis Infection1 , 2006, The Journal of Immunology.
[29] Mohammad Fallahi-Sichani,et al. Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma , 2010, PLoS Comput. Biol..
[30] Jose L. Segovia-Juarez,et al. Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. , 2004, Journal of theoretical biology.
[31] Bernhard O. Palsson,et al. Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets , 2007 .
[32] Johnjoe McFadden,et al. Carbon flux rerouting during Mycobacterium tuberculosis growth arrest , 2010, Molecular microbiology.
[33] John Chan,et al. Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue , 2007, PLoS Comput. Biol..
[34] Mats O. Karlsson,et al. Population Pharmacokinetics of Rifampin in Pulmonary Tuberculosis Patients, Including a Semimechanistic Model To Describe Variable Absorption , 2008, Antimicrobial Agents and Chemotherapy.
[35] Nicola Mulder,et al. A mathematical representation of the development of Mycobacterium tuberculosis active, latent and dormant stages. , 2012, Journal of theoretical biology.
[36] G. Kaplan,et al. Advances in immunotherapy for tuberculosis treatment. , 2009, Clinics in chest medicine.