Layer‐Specific Pathways for the Horizontal Propagation of Epileptiform Discharges in Neocortex

Summary: Purpose: Epileptiform discharges that resemble interictal spikes can be generated by slices of neocortex treated with antagonists of γ‐aminobutyric acid A (GABAA) receptors. These discharges can propagate horizontally for long distances. We tested the hypothesis that propagation occurs through preferred horizontal pathways that lie in a particular cortical layer.

[1]  C E Elger,et al.  Multiple Subpial Transection for Control of Epileptic Seizures: Effectiveness and Safety , 1997, Epilepsia.

[2]  D. Prince,et al.  Burst generating and regular spiking layer 5 pyramidal neurons of rat neocortex have different morphological features , 1990, The Journal of comparative neurology.

[3]  Ta. Pedley,et al.  Epilepsy and the human electroencephalogram , 1984 .

[4]  J. Hablitz.  Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex. , 1987, Journal of neurophysiology.

[5]  U. Kuhnt,et al.  Epileptiform Activity in the Guinea‐pig Neocortical Slice Spreads Preferentially along Supragranular Layers—Recordings with Voltage‐sensitive Dyes , 1995, The European journal of neuroscience.

[6]  T P Bleck,et al.  Multiple subpial transection: a new approach to the surgical treatment of focal epilepsy. , 1989, Journal of neurosurgery.

[7]  D. Prince,et al.  Epileptogenesis in neocortical slices , 1977, Brain Research.

[8]  Charles G. Gross,et al.  Horizontal Propagation of Excitation in Rat Visual Cortical Slices Revealed by Optical Imaging , 2006 .

[9]  P. Schwartzkroin,et al.  Spontaneous Rhythmic Synchronous Activity in Epileptic Human and Normal Monkey Temporal Lobe , 1986, Epilepsia.

[10]  P. Rappelsberger,et al.  Cortical Seizure Patterns in Multidimensional View: The Information Content of Equipotential Maps , 1974, Epilepsia.

[11]  O. Holmes,et al.  Bicuculline epileptogenesis in the rat , 1984, Brain Research.

[12]  Stephen G. Waxman,et al.  The conduction properties of axons in central white matter , 1977, Progress in Neurobiology.

[13]  B. Connors,et al.  Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. , 1991, Science.

[14]  L. Sundstrom,et al.  Multiple subpial transection: report of 7 cases , 1996, Epilepsy Research.

[15]  J. Ebersole,et al.  Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis. , 1986, Advances in neurology.

[16]  T. Ichinose,et al.  Electrophysiological elucidation of pathways of intrinsic horizontal connections in rat visual cortex , 1996, Neuroscience.

[17]  B. Connors.  Initiation of synchronized neuronal bursting in neocortex , 1984, Nature.

[18]  C. Binnie,et al.  Multiple subpial transection: a review of 21 cases. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[19]  B W Connors,et al.  Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex. , 1989, Journal of neurophysiology.

[20]  B. Connors,et al.  Periodicity and directionality in the propagation of epileptiform discharges across neocortex. , 1988, Journal of neurophysiology.

[21]  M. Gutnick,et al.  Non-uniform propagation of epileptiform discharge in brain slices of rat neocortex , 1993, Neuroscience.

[22]  P. Rappelsberger,et al.  Penicillin-induced epileptic phenomena in the rabbit's neocortex II. Laminar specific generation of interictal spikes after the application of penicillin to different cortical depths , 1984, Brain Research.

[23]  D. Carpenter,et al.  Antagonists of gaba responses, studied using internally perfused frog dorsal root ganglion neurons , 1987, Neuroscience.

[24]  Barry W. Connors,et al.  Epilepsy: Generation of epileptiform discharge by local circuits of neocortex , 1993 .

[25]  B. Connors,et al.  Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition. , 1989, Journal of neurophysiology.

[26]  B. Connors,et al.  Functions of Local Circuits in Neocortex: Synchrony and Laminae , 1995 .

[27]  C. Blakemore,et al.  Single-fibre EPSPs in layer 5 of rat visual cortex in vitro. , 1993, Neuroreport.