Magnetic Polymers for Magnetophoretic Separation in Microfluidic Devices

Magnetophoresis offers many advantages for manipulating magnetic targets in microsystems. The integration of micro-flux concentrators and micro-magnets allows achieving large field gradients and therefore large reachable magnetic forces. However, the associated fabrication techniques are often complex and costly, and besides, they put specific constraints on the geometries. Magnetic composite polymers provide a promising alternative in terms of simplicity and fabrication costs, and they open new perspectives for the microstructuring, design, and integration of magnetic functions. In this review, we propose a state of the art of research works implementing magnetic polymers to trap or sort magnetic micro-beads or magnetically labeled cells in microfluidic devices.

[1]  B. Mathew,et al.  Magnetophoresis and Microfluidics: A Great Union , 2020, IEEE Nanotechnology Magazine.

[2]  D. Pang,et al.  Combination of dynamic magnetophoretic separation and stationary magnetic trap for highly sensitive and selective detection of Salmonella typhimurium in complex matrix. , 2015, Biosensors & bioelectronics.

[3]  George M. Whitesides,et al.  Fabrication of magnetic microfiltration systems using soft lithography , 2002 .

[4]  Nicole Pamme,et al.  Magnetism and microfluidics. , 2006, Lab on a chip.

[5]  M. F. Hansen,et al.  Integration of rolling circle amplification and optomagnetic detection on a polymer chip. , 2019, Biosensors & bioelectronics.

[6]  V. Salles,et al.  Magnetic filaments for anisotropic composite polymers , 2020, Nanotechnology.

[7]  M. Faivre,et al.  Anisotropic ferromagnetic polymer: A first step for their implementation in microfluidic systems , 2016 .

[8]  Peng Chen,et al.  Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array , 2015, Scientific Reports.

[9]  R. Anderson,et al.  Anisotropic magnetism in field-structured composites , 1999 .

[10]  Ayub Subandi,et al.  Polymer-Based MEMS Electromagnetic Actuator for Biomedical Application: A Review , 2020, Polymers.

[11]  Ki-Ho Han,et al.  A disposable microfluidic device with a reusable magnetophoretic functional substrate for isolation of circulating tumor cells. , 2017, Lab on a chip.

[12]  A. Deman,et al.  Optimized process for the fabrication of PDMS membranes integrating permanent micro-magnet arrays , 2020 .

[13]  Y. Bae,et al.  Array of 3D permanent micromagnet for immunomagnetic separation , 2019, Journal of Micromechanics and Microengineering.

[14]  Kevin D Dorfman,et al.  Quantitative microfluidic separation of DNA in self-assembled magnetic matrixes. , 2004, Analytical chemistry.

[15]  I. Puri,et al.  Changing the magnetic properties of microstructure by directing the self-assembly of superparamagnetic nanoparticles. , 2015, Faraday discussions.

[16]  A. A. Hamzah,et al.  The Design, Fabrication, and Testing of an Electromagnetic Micropump with a Matrix-Patterned Magnetic Polymer Composite Actuator Membrane , 2017, Micromachines.

[17]  Chia-Wen Tsao,et al.  Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production , 2016, Micromachines.

[18]  C. Ménager,et al.  Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation , 2017, Nature Communications.

[19]  G. Westmeyer,et al.  Microfluidic sorting of intrinsically magnetic cells under visual control , 2017, Scientific Reports.

[20]  Chih-Hao Chang,et al.  Magnetically Actuated Dynamic Iridescence Inspired by the Neon Tetra. , 2019, ACS nano.

[21]  Shashi K Murthy,et al.  Fundamentals and application of magnetic particles in cell isolation and enrichment: a review , 2015, Reports on progress in physics. Physical Society.

[22]  CheolGi Kim,et al.  Nano/micro-scale magnetophoretic devices for biomedical applications , 2017 .

[23]  H. Kotera,et al.  Fabrication of Magnetically Driven Microvalve Arrays Using a Photosensitive Composite , 2018 .

[24]  M. Faivre,et al.  Magnetophoretic manipulation in microsystem using carbonyl iron-polydimethylsiloxane microstructures. , 2014, Biomicrofluidics.

[25]  Jean-Christophe Orlianges,et al.  Thermomagnetically patterned micromagnets , 2010 .

[26]  Microfluidic separation of magnetic nanoparticles on an ordered array of magnetized micropillars. , 2016, Physical review. E.

[27]  Limu Wang,et al.  Design and fabrication of microfluidic mixer from carbonyl iron–PDMS composite membrane , 2011 .

[28]  Shih-Kang Fan,et al.  Genomic DNA extraction from whole blood using a digital microfluidic (DMF) platform with magnetic beads , 2017 .

[29]  Hakho Lee,et al.  Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip. , 2013, Biomicrofluidics.

[30]  G. Bossis,et al.  Magnetic filtration of phase separating ferrofluids: From basic concepts to microfluidic device , 2017 .

[31]  G. Reyne,et al.  Microfluidic immunomagnetic cell separation using integrated permanent micromagnets. , 2013, Biomicrofluidics.

[32]  A. Deman,et al.  Magnetophoresis in Bio-Devices , 2019, Engineering of Micro/Nano Biosystems.

[33]  Xiangchun Xuan,et al.  Recent Advances in Continuous-Flow Particle Manipulations Using Magnetic Fluids , 2019, Micromachines.

[34]  Jean Salamero,et al.  Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays , 2010, Proceedings of the National Academy of Sciences.

[35]  Wu,et al.  Field-Induced Structures in Ferrofluid Emulsions. , 1995, Physical review letters.

[36]  CheolGi Kim,et al.  An on-chip micromagnet frictionometer based on magnetically driven colloids for nano-bio interfaces. , 2016, Lab on a chip.

[37]  P. Onck,et al.  Controlled Multidirectional Particle Transportation by Magnetic Artificial Cilia , 2020, ACS nano.

[38]  N. Dempsey,et al.  Micro-magnetic imprinting of high field gradient magnetic flux sources , 2014 .

[39]  Jean-Louis Viovy,et al.  Self-Assembled Magnetic Matrices for DNA Separation Chips , 2002, Science.

[40]  T. Shibata,et al.  Batch Assembly of SU-8 Movable Components in Channel Under Mild Conditions for Dynamic Microsystems:Application to Biohybrid Systems , 2019, Journal of Microelectromechanical Systems.

[41]  Xue-cheng Sun,et al.  An innovative micro magnetic separator based on 3D micro-copper-coil exciting soft magnetic tips and FeNi wires for bio-target sorting , 2019, Microfluidics and Nanofluidics.

[42]  Ran Zhou,et al.  Microfluidic separation of magnetic particles with soft magnetic microstructures , 2016 .

[43]  H. Kotera,et al.  Self-aligned fabrication process for active membrane in magnetically driven micropump using photosensitive composite , 2020, Journal of Micromechanics and Microengineering.

[44]  P. Sheng,et al.  Characterizing and Patterning of PDMS‐Based Conducting Composites , 2007 .

[45]  J. Camacho,et al.  A Unified View on Magnetic Nanoparticle Separation Under Magnetophoresis. , 2020, Langmuir : the ACS journal of surfaces and colloids.

[46]  Joseph M. Martel-Foley,et al.  Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells , 2017, Scientific Reports.

[47]  T. Veres,et al.  Polymer-based microfluidic chip for rapid and efficient immunomagnetic capture and release of Listeria monocytogenes. , 2015, Lab on a chip.

[48]  Biocompatible Magnetic Nanocomposite Microcapsules as Microfluidic One-way Diffusion Blocking Valves with Ultra-low Opening Pressure. , 2018, Materials & design.

[49]  J. Viovy,et al.  Development of a Droplet Microfluidics Device Based on Integrated Soft Magnets and Fluidic Capacitor for Passive Extraction and Redispersion of Functionalized Magnetic Particles , 2020, Advanced Materials Technologies.

[50]  N. Dempsey,et al.  A quantitative study of magnetic interactions between a micro-magnet array and individual magnetic micro-particles by scanning particle force microscopy , 2018, Journal of Micromechanics and Microengineering.

[51]  D. Haber,et al.  Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells , 2020, Proceedings of the National Academy of Sciences.

[52]  D. Dhungana,et al.  Anisotropic composite polymer for high magnetic force in microfluidic systems , 2017, Microfluidics and Nanofluidics.

[53]  K. Ulgen,et al.  Advances in microfluidic devices made from thermoplastics used in cell biology and analyses. , 2017, Biomicrofluidics.

[54]  Cécile M. Bidan,et al.  Magneto-active substrates for local mechanical stimulation of living cells , 2017, Scientific Reports.

[55]  L. Mao,et al.  Biocompatible and label-free separation of cancer cells from cell culture lines from white blood cells in ferrofluids. , 2017, Lab on a chip.

[56]  C. Tsao,et al.  Magnetic microparticle-polydimethylsiloxane composite for reversible microchannel bonding , 2016, Science and technology of advanced materials.

[57]  Sébastien Lecommandoux,et al.  Magnetic responsive polymer composite materials. , 2013, Chemical Society reviews.

[58]  D. Arnold,et al.  A High-Throughput Microfluidic Magnetic Separation (µFMS) Platform for Water Quality Monitoring , 2019, Micromachines.

[59]  Weihua Li,et al.  Versatile Microfluidic Platforms Enabled by Novel Magnetorheological Elastomer Microactuators , 2018 .

[60]  S. Oscarsson,et al.  Magnetophoretic Transport Line System for Rapid On-Chip Attomole Protein Detection. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[61]  Ran Zhou,et al.  Rapid Microfluidic Mixer Based on Ferrofluid and Integrated Microscale NdFeB-PDMS Magnet , 2019, Micromachines.

[62]  J. D. den Toonder,et al.  Metachronal actuation of microscopic magnetic artificial cilia generates strong microfluidic pumping. , 2020, Lab on a chip.

[63]  Yongqing He,et al.  Magnetically driven microfluidics for isolation of circulating tumor cells , 2020, Cancer medicine.

[64]  Martin A M Gijs,et al.  Microfluidic applications of magnetic particles for biological analysis and catalysis. , 2010, Chemical reviews.

[65]  Nanonewton Magnetophoretic Microtrap Array for Microsystems. , 2020, Langmuir : the ACS journal of surfaces and colloids.

[66]  Marie Frénéa-Robin,et al.  Characterization of C-PDMS electrodes for electrokinetic applications in microfluidic systems , 2011 .

[67]  Bonnie L. Gray,et al.  A Review of Magnetic Composite Polymers Applied to Microfluidic Devices , 2014 .

[68]  Microfluidic active mixers employing ultra-high aspect-ratio rare-earth magnetic nano-composite polymer artificial cilia , 2014 .

[69]  K. Hoshino,et al.  Micromagnetic Cancer Cell Immobilization and Release for Real-Time Single Cell Analysis , 2017 .

[70]  Hui Yang,et al.  Label-free separation of nanoscale particles by an ultrahigh gradient magnetic field in a microfluidic device. , 2021, Nanoscale.

[71]  Shawn A. Chester,et al.  Printing ferromagnetic domains for untethered fast-transforming soft materials , 2018, Nature.

[72]  Chang Lu,et al.  Paramagnetic Structures within a Microfluidic Channel for Enhanced Immunomagnetic Isolation and Surface Patterning of Cells , 2016, Scientific Reports.

[73]  J. Josserand,et al.  Magnetic track array for efficient bead capture in microchannels , 2009, Analytical and bioanalytical chemistry.

[74]  Jaap den Toonder,et al.  Microfluidic magnetic bead conveyor belt. , 2017, Lab on a chip.

[75]  Olivier Sandre,et al.  Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness , 2018, Nanomaterials.

[76]  M. Javanmard,et al.  Magnetically Actuated Microfluidic Transistors: Miniaturized Micro-Valves Using Magnetorheological Fluids Integrated With Elastomeric Membranes , 2016, Journal of Microelectromechanical Systems.

[77]  Quanliang Cao,et al.  Recent advances in manipulation of micro- and nano-objects with magnetic fields at small scales , 2020 .

[78]  Ran Zhou,et al.  Study on micromagnets induced local wavy mixing in a microfluidic channel , 2020 .

[79]  A. Athanassiou,et al.  Nanochains Formation of Superparamagnetic Nanoparticles , 2011 .

[80]  Chuan Song,et al.  Multiplex measurement of twelve tumor markers using a GMR multi-biomarker immunoassay biosensor. , 2019, Biosensors & bioelectronics.

[81]  D. Pang,et al.  Control of magnetic field distribution by using nickel powder@PDMS pillars in microchannels , 2014 .

[82]  Maciej Zborowski,et al.  Magnetic cell separation: characterization of magnetophoretic mobility. , 2003, Analytical chemistry.

[83]  H. Redl,et al.  Bedside Immune Monitoring: An Automated Immunoassay Platform for Quantification of Blood Biomarkers in Patient Serum within 20 Minutes. , 2017, Analytical chemistry.

[84]  J. Marchalot,et al.  Using injection molding and reversible bonding for easy fabrication of magnetic cell trapping and sorting devices , 2017 .

[85]  Susana Cardoso,et al.  Implementing a strategy for on-chip detection of cell-free DNA fragments using GMR sensors: A translational application in cancer diagnostics using ALU elements , 2016 .

[86]  Majid Ashouri,et al.  Theoretical and experimental studies of a magnetically actuated valveless micropump , 2016 .

[87]  Le He,et al.  Magnetic field guided colloidal assembly , 2013 .

[88]  Feng Bai,et al.  Fabrication and integration of microscale permanent magnets for particle separation in microfluidics , 2016 .

[89]  D. Pang,et al.  Magnetic Chip based Extracorporeal Circulation: A New Tool for Circulating Tumor Cell In vivo Detection. , 2019, Analytical chemistry.

[90]  M. Tahmasebipour,et al.  An electromagnetic micro-actuator with PDMS-Fe3O4 nanocomposite magnetic membrane , 2019, Microelectronic Engineering.

[91]  B. Evans,et al.  Active Periodic Magnetic Nanostructures with High Aspect Ratio and Ultrahigh Pillar Density. , 2020, ACS applied materials & interfaces.

[92]  N. Nguyen,et al.  Recent advances and current challenges in magnetophoresis based micro magnetofluidics. , 2018, Biomicrofluidics.

[93]  Frédéric Dumas-Bouchiat,et al.  Fabrication and characterization of polymer membranes with integrated arrays of high performance micro-magnets , 2016 .