Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.
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D. Kassel | S. L. Gwaltney | Lihong Shi | R. Skene | Zhiyuan Zhang | M. Wallace | Jun Feng | Chris L. Caster | R. Xu | M. B. Wallace
[1] Rongda Xu,et al. Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation. , 2007, Journal of chromatography. A.
[2] B. Ahrén. Dipeptidyl Peptidase-4 Inhibitors , 2007, Diabetes Care.
[3] D. Kassel,et al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. , 2007, Journal of medicinal chemistry.
[4] C. Bailey,et al. Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes , 2006, Diabetes & vascular disease research.
[5] D. Drucker,et al. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes , 2006, The Lancet.
[6] W. Zeng,et al. Pharmacokinetics and Pharmacodynamic Effects of the Oral DPP‐4 Inhibitor Sitagliptin in Middle‐Aged Obese Subjects , 2006, Journal of clinical pharmacology.
[7] B. Ahrén. Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties , 2006, Expert opinion on investigational drugs.
[8] Christian Rummey,et al. In silico fragment-based discovery of DPP-IV S1 pocket binders. , 2006, Bioorganic & medicinal chemistry letters.
[9] R. Parker,et al. Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. , 2005, Journal of medicinal chemistry.
[10] G. Scapin,et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. , 2005, Journal of medicinal chemistry.
[11] Eberhard Standl,et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. , 2004, Diabetes care.
[12] Manfred Kansy,et al. An aminomethylpyrimidine DPP-IV inhibitor with improved properties. , 2004, Bioorganic & medicinal chemistry letters.
[13] R. Parker,et al. Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors. , 2004, Journal of medicinal chemistry.
[14] Silja Weber,et al. Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents. , 2004, Bioorganic & medicinal chemistry letters.
[15] T. Hughes,et al. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. , 2003, Journal of medicinal chemistry.
[16] Robert Huber,et al. The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[17] J. Peterson,et al. Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. , 2003, Journal of medicinal chemistry.
[18] D. Drucker,et al. Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes , 2003, Expert opinion on investigational drugs.
[19] S. L. Gwaltney,et al. Inhibitors of Dipeptidyl Peptidase 4 , 2005 .
[20] F. Naider,et al. Proline-dependent structural and biological properties of peptides and proteins. , 1993, Critical reviews in biochemistry and molecular biology.
[21] I Born,et al. Mechanism of proline-specific proteinases: (I) Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum. , 1988, Biochimica et biophysica acta.