Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK

[1]  Yuxin Chen,et al.  RIP1 kinase inactivation protects against acetaminophen-induced acute liver injury in mice. , 2021, Free radical biology & medicine.

[2]  M. Aghajan,et al.  Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity , 2021, The Journal of biological chemistry.

[3]  F. Chan,et al.  Regulatory mechanisms of RIPK1 in cell death and inflammation. , 2020, Seminars in cell & developmental biology.

[4]  M. Bertrand,et al.  RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events. , 2020, Trends in cell biology.

[5]  Salim S. Al-Rejaie,et al.  Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity? , 2019, Drug development research.

[6]  H. Jaeschke,et al.  Acetaminophen Hepatotoxicity , 2019, Seminars in Liver Disease.

[7]  S. Henderson,et al.  TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation , 2018, Nature Cell Biology.

[8]  Junying Yuan,et al.  TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging , 2018, Cell.

[9]  Chen Zhang,et al.  CD36 deficiency attenuates immune‐mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10 , 2018, Hepatology.

[10]  M. Bertrand,et al.  MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death , 2017, Nature Cell Biology.

[11]  Junying Yuan,et al.  Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis , 2017, Nature Communications.

[12]  H. Jaeschke,et al.  Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. , 2017, Journal of hepatology.

[13]  M. Bertrand,et al.  RIPK1 protects from TNF-α-mediated liver damage during hepatitis , 2016, Cell Death & Disease.

[14]  D. Coppola,et al.  IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR. , 2016, Cancer research.

[15]  N. Kaplowitz,et al.  Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis , 2015, Hepatology.

[16]  M. Bertrand,et al.  NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. , 2015, Molecular cell.

[17]  Mitchell R. McGill,et al.  Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity , 2015, Expert opinion on drug metabolism & toxicology.

[18]  Junying Yuan,et al.  Activation of necroptosis in multiple sclerosis. , 2015, Cell reports.

[19]  M. Pasparakis,et al.  Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis , 2014, Proceedings of the National Academy of Sciences.

[20]  K. Iwaisako,et al.  Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure , 2014, FEBS open bio.

[21]  M. Pasparakis,et al.  RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis , 2014, Nature.

[22]  Cheng-Jun Hu,et al.  Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. , 2013, Biochemical pharmacology.

[23]  C. Trautwein,et al.  ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis. , 2013, Journal of hepatology.

[24]  J. Cheng,et al.  IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer , 2013, Oncogene.

[25]  P. Vandenabeele,et al.  Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models , 2012, Cell Death and Disease.

[26]  Hartmut Jaeschke,et al.  Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[27]  David C. Jones,et al.  Hyponatremia in patients with acute variceal bleeding treated with terlipressin , 2011, Hepatology.

[28]  H. Jaeschke,et al.  c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. , 2010, Toxicology and applied pharmacology.

[29]  C. Glass,et al.  Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. , 2009, Molecular cell.

[30]  B. Biteau,et al.  JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. , 2008, Cell stem cell.

[31]  L. Pohl,et al.  Pathogenic role of natural killer T and natural killer cells in acetaminophen‐induced liver injury in mice is dependent on the presence of dimethyl sulfoxide , 2008, Hepatology.

[32]  J. Gatot,et al.  Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? , 2008, Trends in biochemical sciences.

[33]  S. Akira,et al.  Identification of a key pathway required for the sterile inflammatory response triggered by dying cells , 2007, Nature Medicine.

[34]  R. Flavell,et al.  Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure , 2006, Gut.

[35]  K. Honda,et al.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors , 2006, Nature Reviews Immunology.

[36]  J. Chung,et al.  Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice. , 2006, Biological & pharmaceutical bulletin.

[37]  H. Jaeschke,et al.  Role of caspases in acetaminophen-induced liver injury. , 2006, Life sciences.

[38]  R. Schwabe,et al.  Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α* , 2005, Journal of Biological Chemistry.

[39]  A. Y. Lu,et al.  N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Hartmut Jaeschke,et al.  Intracellular signaling mechanisms of acetaminophen-induced liver cell death. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[41]  William M. Lee,et al.  LIVER FAILURE AND LIVER DISEASE LIVER FAILURE Acetaminophen-Induced Acute Liver Failure: Results of a United States Multicenter, Prospective Study , 2005 .