The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families and their members as well as relevant links to gene databases and reviews in the literature. A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction.

[1]  Peter J. Meier,et al.  Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties , 2004, Pflügers Archiv.

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[4]  M. Ruat,et al.  An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

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[6]  William A Catterall,et al.  Overview of the voltage-gated sodium channel family , 2003, Genome Biology.

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[8]  F. Meunier,et al.  Selection and Characterization of the Choline Transport Mutation Suppressor from Torpedo Electric Lobe, CTL1 , 2003, Neurochemical Research.

[9]  R. Penzel,et al.  Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient , 2002, FEBS letters.

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[11]  Youxing Jiang,et al.  The principle of gating charge movement in a voltage-dependent K+ channel , 2003, Nature.

[12]  Tsung-Yu Chen,et al.  Coupling Gating with Ion Permeation in ClC Channels , 2003, Science's STKE.

[13]  H. Aasheim,et al.  The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. , 2003, Biochemical and biophysical research communications.

[14]  P. Borst,et al.  Mammalian ABC transporters in health and disease. , 2002, Annual review of biochemistry.

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[16]  T. DeCoursey.  Voltage-gated proton channels and other proton transfer pathways. , 2003, Physiological reviews.

[17]  M. Kawakita,et al.  Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) , 2004, Pflügers Archiv.

[18]  C. Armstrong.  Voltage-Gated K Channels , 2003, Science's STKE.

[19]  M. Caplan,et al.  The cell biology of ion pumps: sorting and regulation. , 2000, European journal of cell biology.

[20]  M. Maguire,et al.  Cloning and characterization of MgtE, a putative new class of Mg2+ transporter from Bacillus firmus OF4 , 1995, Journal of bacteriology.

[21]  Steven D. P. Moore,et al.  Copper Transporting P-Type ATPases and Human Disease , 2002, Journal of bioenergetics and biomembranes.

[22]  V. Müller,et al.  ATP synthases: structure, function and evolution of unique energy converters , 2003, Cellular and Molecular Life Sciences CMLS.

[23]  H. Gunshin,et al.  Expression cloning using Xenopus laevis oocytes. , 1998, Methods in enzymology.