Losartan modifies glomerular hyperfiltration and insulin sensitivity in type 1 diabetes

Aim: The effect of the angiotensin II receptor antagonist losartan on renal haemodynamics and insulin‐mediated glucose disposal was examined in normotensive, normoalbuminuric type 1 diabetic patients using a double‐blind, placebo‐controlled, cross‐over design.

[1]  J. Gross,et al.  Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study. , 1999, Diabetes care.

[2]  H. Parving,et al.  Randomised controlled trial of long term efficacy of captopril on preservation of kidney function in normotensive patients with insulin dependent diabetes and microalbuminuria , 1999, BMJ.

[3]  B. Grabensee,et al.  Effects of the angiotensin II antagonist valsartan on blood pressure, proteinuria, and renal hemodynamics in patients with chronic renal failure and hypertension. , 1998, Journal of the American Society of Nephrology : JASN.

[4]  R. Fogari,et al.  Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertensive patients. , 1998, British journal of clinical pharmacology.

[5]  P. Weidmann,et al.  Effects of angiotensin II-receptor blockade with losartan on insulin sensitivity, lipid profile, and endothelin in normotensive offspring of hypertensive parents. , 1998, Journal of cardiovascular pharmacology.

[6]  S. Kjeldsen,et al.  Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo. , 1998, Metabolism: clinical and experimental.

[7]  L. Velloso,et al.  Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action , 1997, Diabetes.

[8]  G. Paolisso,et al.  Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients , 1997, Journal of Human Hypertension.

[9]  S. Nielsen,et al.  Losartan reduces albuminuria in patients with essential hypertension. An enalapril controlled 3 months study. , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[10]  D. Wheeler Should hyperlipidaemia in dialysis patients be treated? , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[11]  G. Viberti,et al.  Glomerular Hyperfiltration in the Prediction of Nephropathy in IDDM: A 10-Year Follow-Up Study , 1996, Diabetes.

[12]  R. Carey,et al.  Renin-angiotensin system modulates renal bradykinin production. , 1996, The American journal of physiology.

[13]  M. Laakso,et al.  Effects of losartan on insulin sensitivity in hypertensive subjects. , 1996, Hypertension.

[14]  S. Kjeldsen,et al.  The effect of angiotensin II receptor antagonism with losartan on glucose metabolism and insulin sensitivity , 1996, Journal of hypertension.

[15]  M. Laville,et al.  Effects of losartan on renal function in patients with essential hypertension. , 1996, Journal of cardiovascular pharmacology.

[16]  M. Burnier,et al.  Renal effects of angiotensin II receptor blockade in normotensive subjects. , 1996, Kidney international.

[17]  B. Brenner,et al.  The hyperfiltration theory: a paradigm shift in nephrology. , 1996, Kidney international.

[18]  G. Reaven,et al.  Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system. , 1996, The New England journal of medicine.

[19]  I. Tikkanen,et al.  Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension , 1995, Journal of hypertension.

[20]  S. Kjeldsen,et al.  Effects of losartan on insulin sensitivity in severe hypertension: connections through sympathetic nervous system activity? , 1995, Journal of human hypertension.

[21]  R. Herings,et al.  Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme , 1995, The Lancet.

[22]  D. de Zeeuw,et al.  Effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease. , 1994, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[23]  S. Kjeldsen,et al.  The effect of angiotensin II receptor blockade on insulin sensitivity and sympathetic nervous system activity in primary hypertension. , 1994, Blood pressure.

[24]  D. de Zeeuw,et al.  Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system? , 1994, Kidney international.

[25]  L. Groop,et al.  Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria , 1994 .

[26]  L. Groop,et al.  Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. , 1994, JAMA.

[27]  A Fournier,et al.  The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. , 1994, The New England journal of medicine.

[28]  R. Bain,et al.  The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. , 1993, The New England journal of medicine.

[29]  R. Trevisan,et al.  Insulin resistance in insulin-dependent diabetic patients with microalbuminuria , 1993, The Lancet.

[30]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[31]  R. DeFronzo Insulin Resistance, Hyperinsulinemia, and Coronary Artery Disease: A Complex Metabolic Web , 1992, Journal of cardiovascular pharmacology.

[32]  T. Meyer,et al.  Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. , 1992, The Journal of clinical investigation.

[33]  G. Dahlquist,et al.  Increased glomerular filtration rate as a predictor of diabetic nephropathy--an 8-year prospective study. , 1992, Kidney international.

[34]  C. Berne,et al.  Effects of Antihypertensive Treatment on Insulin Sensitivity With Special Reference to ACE Inhibitors , 1991, Diabetes Care.

[35]  H. Parving,et al.  Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. , 1991, BMJ.

[36]  H. Danielsen,et al.  Acute and Long‐term Renal Effects of Angiotensin Converting Enzyme Inhibition in Normotensive, Normoalbuminuric Insulin‐dependent Diabetic Patients , 1988, Diabetic medicine : a journal of the British Diabetic Association.

[37]  E. Ferrannini The theoretical bases of indirect calorimetry: a review. , 1988, Metabolism: clinical and experimental.

[38]  R N Bergman,et al.  Estimation of Endogenous Glucose Production During Hyperinsulinemic-Euglycemic Glucose Clamps: Comparison of Unlabeled and Labeled Exogenous Glucose Infusates , 1987, Diabetes.

[39]  H. Yki-Järvinen,et al.  Natural course of insulin resistance in type I diabetes. , 1986, The New England journal of medicine.

[40]  B. Brenner,et al.  Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. , 1986, The Journal of clinical investigation.

[41]  C. Mogensen Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathy. , 1986, Scandinavian journal of clinical and laboratory investigation.

[42]  C. Mogensen,et al.  The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy , 1983, Diabetes.

[43]  S. Colagiuri,et al.  The Diabetes Control and Complications Trial , 1983, Henry Ford Hospital medical journal.

[44]  R. DeFronzo,et al.  Insulin Resistance is a Prominent Feature of Insulin-dependent Diabetes , 1982, Diabetes.

[45]  K. Alberti,et al.  Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. , 1978, Clinical chemistry.

[46]  Mogensen Ce Glomerular Filtration Rate and Renal Plasma Flow in Short-term and Long-term Juvenile Diabetes Mellitus , 1971 .

[47]  H. Ørskov,et al.  Wick Chromatography for Rapid and Reliable Immunoassay of Insulin, Glucagon and Growth Hormone , 1968, Nature.

[48]  R. Steele,et al.  ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE. , 1963, Recent progress in hormone research.