Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin. Many attempts have been undertaken previously to create animal models of chronic inflammatory demyelinating diseases through autoimmunity or virus infection. Recently, however, a new model of myelin oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis became available, which, in a very standardized and predictable way, leads to chronic (relapsing or progressive) disease and widespread CNS demyelination.

[1]  H. Lassmann,et al.  Immunopathology of multiple sclerosis: Report on an international meeting held at the Institute of Neurology of the University of Vienna , 1998, Journal of Neuroimmunology.

[2]  H. Lassmann,et al.  Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination , 1998, Annals of neurology.

[3]  C. Raine,et al.  Multiple sclerosis: Oligodendrocytes display cell death–related molecules in situ but do not undergo apoptosis , 1997, Annals of neurology.

[4]  Hans Lassmann,et al.  Pathology and pathogenesis of demyelinating diseases , 1997, Current opinion in neurology.

[5]  H. Lassmann,et al.  Patterns of oligodendrocyte pathology in coronavirus‐induced subacute demyelinating encephalomyelitis in the lewis rat , 1997, Glia.

[6]  S. Hauser,et al.  Late Complications of Immune Deviation Therapy in a Nonhuman Primate , 1996, Science.

[7]  J. Antel,et al.  Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death , 1996, The Journal of experimental medicine.

[8]  P. Goodfellow,et al.  A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22 , 1996, Nature Genetics.

[9]  J. Haines,et al.  A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex , 1996, Nature Genetics.

[10]  D. Hinds,et al.  A full genome search in multiple sclerosis , 1996, Nature Genetics.

[11]  Moses Rodriguez,et al.  Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis , 1996, Brain pathology.

[12]  R S Howard,et al.  Clinical, CSF, and MRI findings in Devic's neuromyelitis optica. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[13]  H. Lassmann,et al.  The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat , 1995, Journal of Neuroimmunology.

[14]  S. Miller,et al.  Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison , 1995, Microscopy research and technique.

[15]  T. Johns,et al.  Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. , 1995, Journal of immunology.

[16]  K. Jellinger,et al.  Patterns of oligodendroglia pathology in multiple sclerosis. , 1994, Brain : a journal of neurology.

[17]  O. Majdic,et al.  Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. , 1994, Journal of immunology.

[18]  H. Lassmann,et al.  Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. , 1994, Journal of immunology.

[19]  Moses Rodriguez,et al.  Proteolipid Protein Gene Expression in Demyelination and Remyelination of the Central Nervous System: A Model for Multiple Sclerosis , 1994, Journal of neuropathology and experimental neurology.

[20]  J. Fazakerley,et al.  Pathogenesis of Virus-Induced Demyelination , 1993, Advances in Virus Research.

[21]  H. Lassmann,et al.  Interferon‐γ potentiates antibody‐mediated demyelination in vivo , 1992 .

[22]  A. Sadovnick,et al.  Epidemiology and genetics of multiple sclerosis. , 1992, Current opinion in neurology and neurosurgery.

[23]  H. Lassmann,et al.  Interferon-gamma potentiates antibody-mediated demyelination in vivo. , 1992, Annals of neurology.

[24]  M. Esiri,et al.  Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study. , 1991, Brain : a journal of neurology.

[25]  H. Lassmann,et al.  Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein , 1990, Journal of neurochemistry.

[26]  C. Godfraind,et al.  Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus , 2004, Glia.

[27]  H. Lassmann,et al.  Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. , 1988, The American journal of pathology.

[28]  D. Paty,et al.  A population-based study of multiple sclerosis in twins. , 1986, The New England journal of medicine.

[29]  J. E. Wagner,et al.  Characterization of strain specific typing antisera for genetic monitoring of inbred strains of rats. , 1985, Laboratory animal science.

[30]  Dr. med. Hans Lassmann.  Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis , 1983, Schriftenreihe Neurologie / Neurology Series.

[31]  M. D. Dal Canto,et al.  Experimental models of virus‐induced demyelination of the central nervous system , 1982, Annals of neurology.

[32]  J. Prineas,et al.  Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown , 1981, Annals of neurology.

[33]  I. Cohen,et al.  The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis , 1981, European journal of immunology.

[34]  F. Roncaroli,et al.  Neuropathology of multiple sclerosis , 2012 .

[35]  S. H. Stone,et al.  CHRONIC DISSEMINATED ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIGS * , 1965, Annals of the New York Academy of Sciences.

[36]  T. Rivers,et al.  OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS , 1933, The Journal of experimental medicine.

[37]  J. Baló.  ENCEPHALITIS PERIAXIALIS CONCENTRICA , 1928 .

[38]  P. Schilder.  Zur Kenntnis der sogenannten diffusen Sklerose. (Über Encephalitis periaxialis diffusa.) , 1912 .