Three-dimensional biocompatible matrix for reconstructive surgery

A study into the development of an original bioengineered structure for reconstruction of hollow organs is presented. The basis for the structure was the creation of a mesh matrix made from titanium nickelide (NiTi), which has sufficient elasticity and shape memory for the reconstruction of hollow tubular orgrans. In order to increase the cell adhesion on the surface of the matrix, the grid needed to be cleaned of impurities, for which we used an ionic cleaning method. Additional advantages also may enable the application of the bioactive component to grid surface. These features of the matrix may improve the biocompatibility properties of the composite material. In the first stage, a mesh structure was made from NiTi fibers. The properties of the resulting mesh matrix were studied. In the second stage, the degrees of adhesion and cell growth rates in the untreated matrix, the matrix after ionic cleaning and the matrix after ionic cleaning and the application of the bioactive component were compared. The ...

[1]  E. Quandt,et al.  Microstructured Nickel-Titanium Thin Film Leaflets for Hybrid Tissue Engineered Heart Valves Fabricated by Magnetron Sputter Deposition , 2016, Cardiovascular Engineering and Technology.

[2]  Charanpreet Singh,et al.  A new design concept for knitted external vein-graft support mesh. , 2015, Journal of the mechanical behavior of biomedical materials.

[3]  G. Cattaneo,et al.  Temporary implantable nitinol device (TIND): a novel, minimally invasive treatment for relief of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH): feasibility, safety and functional results at 1 year of follow‐up , 2015, BJU international.

[4]  A. Kheradvar,et al.  A Hybrid Tissue-Engineered Heart Valve. , 2015, The Annals of thoracic surgery.

[5]  Thomas Schmitz-Rode,et al.  Tissue-engineered heart valve with a tubular leaflet design for minimally invasive transcatheter implantation. , 2014, Tissue engineering. Part C, Methods.

[6]  Egbert Oosterwijk,et al.  Recent Advances in Ureteral Tissue Engineering , 2014, Current Urology Reports.

[7]  R. Santucci,et al.  Management of iatrogenic ureteral injury , 2014, Therapeutic advances in urology.

[8]  J. Lang,et al.  Anatomic and sexual outcomes after vaginoplasty using tissue-engineered biomaterial graft in patients with Mayer-Rokitansky-Küster-Hauser syndrome: a new minimally invasive and effective surgery. , 2013, The journal of sexual medicine.

[9]  Arash Kheradvar,et al.  Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet , 2012, Annals of Biomedical Engineering.

[10]  O. Engel,et al.  15 TISSUE - ENGINEERED BUCCAL MUCOSA URETHROPLASTY. OUTCOME OF OUR FIRST 10 PATIENTS , 2012 .

[11]  A. Abolyosr,et al.  Buccal mucosa graft for ureteral stricture substitution: initial experience. , 2010, Urology.

[12]  Anthony Atala,et al.  Tissue Engineering a Complete Vaginal Replacement From a Small Biopsy of Autologous Tissue , 2008, Transplantation.

[13]  S. MacNeil,et al.  Tissue-engineered buccal mucosa urethroplasty-clinical outcomes. , 2008, European urology.

[14]  Benjamin R. Lee,et al.  First prize: ureteral segmental replacement revisited. , 2005, Journal of endourology.

[15]  A. Seccia,et al.  Neovaginal Reconstruction With the Modified McIndoe Technique: A Review of 32 Cases , 2002, Annals of plastic surgery.

[16]  R. Hohenfellner,et al.  The use of isolated caecal bowel segment in complicated vaginal reconstruction , 2000, BJU international.

[17]  V. Pansadoro,et al.  Iatrogenic prostatic urethral strictures: classification and endoscopic treatment. , 1999, Urology.

[18]  W. Hendren,et al.  Repair of the high vagina in girls with severely masculinized anatomy from the adrenogenital syndrome. , 1995, Journal of pediatric surgery.

[19]  A. Atala,et al.  Use of bowel for vaginal reconstruction. , 1994, The Journal of urology.