Static and Dynamic Pupillary Characteristics in Clinically Unilateral Pseudoexfoliation Syndrome

Purpose: The purpose of this study was to perform a comparison of static and dynamic pupillometry measurements in patients with clinically unilateral pseudoexfoliation syndrome (PES) and age-matched controls. Methods: This prospective cross-sectional study consisted of 38 patients with unilateral PES and 40 control participants. A quantitative pupillometry system was used to evaluate the pupil characteristics of eyes with PES (group 1), clinically unaffected fellow eyes (group 2), and healthy eyes (group 3). Static pupillometry measurements including scotopic pupil diameter (PD), mesopic PD, low photopic PD, and high photopic PD were undertaken. Subsequently, dynamic pupillometry measurements including resting diameter, amplitude of pupil contraction, latency of pupil contraction, duration of pupil contraction, velocity of pupil contraction, latency of pupil dilation, duration of pupil dilation, and velocity of pupil dilation were undertaken. Results: There were statistically significant differences between the groups with regard to scotopic PD, mesopic PD, and low photopic PD (P<0.001). The pairwise comparisons exhibited that group 1 shows significantly lower PD values compared with groups 2 and 3. Group 2 also had significantly lower PD values compared with group 3. In addition, groups 1 and 2 had statistically significantly lower values of amplitude of pupil contraction, velocity of pupil contraction, duration of pupil dilatation, and velocity of pupil dilatation values compared with group 3. Moreover, group 1 and 2 demonstrated statistically significantly prolonged latency of pupil dilatation compared with group 3. Conclusions: Static and dynamic pupil characteristics of affected eyes and their fellow eyes of cases with unilateral PES are different from the healthy subjects.