Rac1 as a therapeutic anticancer target: promises and limitations.

[1]  Chao Liu,et al.  Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats , 2022, Frontiers in Molecular Neuroscience.

[2]  C. Bailly,et al.  Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder , 2022, Biomedicines.

[3]  Yikai Tang,et al.  Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[4]  P. Aspenström.  The Role of Fast-Cycling Atypical RHO GTPases in Cancer , 2022, Cancers.

[5]  C. Bailly,et al.  Overexpressed or hyperactivated Rac1 as a target to treat hepatocellular carcinoma. , 2022, Pharmacological research.

[6]  S. Saad,et al.  Rac GTPases in acute myeloid leukemia cells: Expression profile and biological effects of pharmacological inhibition. , 2022, Toxicology and applied pharmacology.

[7]  Yongjin Sun,et al.  Rac1 regulates nucleus pulposus cells degeneration and promotes the progression of intervertebral disc degeneration. , 2022, American journal of physiology. Cell physiology.

[8]  T. Peng,et al.  Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice , 2022, Journal of Cardiovascular Translational Research.

[9]  T. Iwama,et al.  Thrombopoietin and collagen in low doses cooperatively induce human platelet activation , 2022, Acute medicine & surgery.

[10]  J. Butcher,et al.  Rac1 mediates Cadherin-11 induced cellular pathogenic processes in aortic valve calcification. , 2022, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[11]  Hongbai Wang,et al.  S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats , 2021, Cellular and Molecular Neurobiology.

[12]  Yajie Yang,et al.  Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition , 2021, Journal of clinical and translational hepatology.

[13]  P. Striano,et al.  Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathies , 2021, Cells.

[14]  K. Nagata,et al.  Expression Analyses of Rac3, a Rho Family Small GTPase, during Mouse Brain Development , 2021, Developmental Neuroscience.

[15]  B. Casar,et al.  RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma , 2021, Biomolecules.

[16]  M. Bayro,et al.  Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer , 2021, Molecular Cancer Therapeutics.

[17]  Haibo Wang,et al.  Regulation of Rac1 Activation in Choroidal Endothelial Cells: Insights into Mechanisms in Age-Related Macular Degeneration , 2021, Cells.

[18]  S. Tawata,et al.  p21-Activated kinase 1 (PAK1) in aging and longevity: An overview , 2021, Ageing Research Reviews.

[19]  Hannah A. Blair.  Sotorasib: First Approval , 2021, Drugs.

[20]  M. Ahmadian,et al.  The RHO Family GTPases: Mechanisms of Regulation and Signaling , 2021, Cells.

[21]  Zhiwei Wu,et al.  NSC23766 and Ehop016 suppress herpes simplex virus-1 replication by inhibiting Rac1 activity. , 2021, Biological & pharmaceutical bulletin.

[22]  R. Veluthakal,et al.  Emerging Roles of Small GTPases in Islet β-Cell Function , 2021, Cells.

[23]  Q. Liao,et al.  Rac1, A Potential Target for Tumor Therapy , 2021, Frontiers in oncology.

[24]  A. von Kriegsheim,et al.  RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways , 2021, Nature Communications.

[25]  T. Takano,et al.  Role of Rho GTPase Interacting Proteins in Subcellular Compartments of Podocytes , 2021, International journal of molecular sciences.

[26]  Akiyoshi Uemura,et al.  Rho GTPases in Retinal Vascular Diseases , 2021, International journal of molecular sciences.

[27]  Hui Cao,et al.  Rac3 Expression and its Clinicopathological Significance in Patients With Bladder Cancer , 2021, Pathology & Oncology Research.

[28]  E. Goka,et al.  Hormone-Dependent Prostate Cancers are Dependent on Rac Signaling for Growth and Survival , 2021, Molecular Cancer Therapeutics.

[29]  A. Magnan,et al.  Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling , 2021, Thorax.

[30]  B. Herrmann,et al.  RAC1 controls progressive movement and competitiveness of mammalian spermatozoa , 2021, PLoS genetics.

[31]  L. Hudson,et al.  The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo , 2021, BMC cancer.

[32]  Luis D. Borrero-García,et al.  Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer , 2020, BMC cancer.

[33]  Liyan Xu,et al.  Computational Prediction of Hot Spots and Binding Site of Inhibitor NSC23766 on Rac1 Binding With Tiam1 , 2021, Frontiers in Chemistry.

[34]  A. Turjanski,et al.  Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer , 2020, ChemMedChem.

[35]  S. Rayala,et al.  Clinical Evaluation of P21 Activated Kinase 1 (PAK1) Activation in Gliomas and Its Effect on Cell Proliferation , 2020, Cancer investigation.

[36]  F. Wei,et al.  Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders , 2020, Neural plasticity.

[37]  T. Keck,et al.  The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling , 2020, Cancers.

[38]  Zhendan He,et al.  P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer , 2020, Theranostics.

[39]  V. Lougaris,et al.  RAC2 and primary human immune deficiencies , 2020, Journal of leukocyte biology.

[40]  F. McCormick,et al.  RAS-targeted therapies: is the undruggable drugged? , 2020, Nature Reviews Drug Discovery.

[41]  P. Chaturvedi,et al.  Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch , 2020, Molecular Cancer Therapeutics.

[42]  Dingchao Zhu,et al.  Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/β‐catenin pathway , 2020, Journal of cellular and molecular medicine.

[43]  E. Li,et al.  Rho GTPases: Promising Candidates for Overcoming Chemotherapeutic Resistance. , 2020, Cancer letters.

[44]  Xue Chen.  Rac1 regulates platelet microparticles formation and rheumatoid arthritis deterioration , 2020, Platelets.

[45]  H. Lehnert,et al.  RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition , 2019, Cells.

[46]  Shui-juan Zhang,et al.  Inhibition of Rac1 activity alleviates PM2.5-induced pulmonary inflammation via the AKT signaling pathway. , 2019, Toxicology letters.

[47]  E. Li,et al.  RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes , 2019, Molecular oncology.

[48]  L. Hudson,et al.  Dual Actions of Ketorolac in Metastatic Ovarian Cancer , 2019, Cancers.

[49]  A. Kowluru,et al.  Functional Regulation of an Oxidative Stress Mediator, Rac1, in Diabetic Retinopathy , 2019, Molecular Neurobiology.

[50]  Jiaqi Tang,et al.  Rac‐GTPase promotes fibrotic TGF‐β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[51]  P. Chaturvedi,et al.  RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer , 2019, Molecular Cancer Therapeutics.

[52]  H. Lehnert,et al.  RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression , 2019, Cells.

[53]  P. Aspenström.  Fast-cycling Rho GTPases , 2020, Small GTPases.

[54]  Hua Liang,et al.  Pharmacological inhibition of Rac1 exerts a protective role in ischemia/reperfusion-induced renal fibrosis. , 2018, Biochemical and biophysical research communications.

[55]  You-hong Cui,et al.  RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3 , 2018, Laboratory Investigation.

[56]  M. Passafaro,et al.  Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities , 2018, International journal of molecular sciences.

[57]  C. Vlaar,et al.  Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents. , 2018, Bioorganic & medicinal chemistry.

[58]  T. Greiner,et al.  Rac1 is a novel therapeutic target in mantle cell lymphoma , 2018, Blood Cancer Journal.

[59]  L. Cubano,et al.  Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer , 2017, Molecular Cancer Therapeutics.

[60]  E. Bancalari,et al.  Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia , 2016, Neonatology.

[61]  Vaibhav Sidarala,et al.  VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells , 2015, Diabetologia.

[62]  L. Hudson,et al.  R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis , 2015, Molecular Cancer Therapeutics.

[63]  J. Rodríguez-Orengo,et al.  The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model , 2014, Translational oncology.

[64]  M. Primeau,et al.  [A brief overview of the small Rho GTPases]. , 2008, Medecine sciences : M/S.

[65]  Yi Zheng,et al.  Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Krister Wennerberg,et al.  Rho-family GTPases: it's not only Rac and Rho (and I like it) , 2004, Journal of Cell Science.

[67]  P. Jordan,et al.  Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors , 1999, Oncogene.