Non-genetic individuality: chance in the single cell

The individuality of bacterial cells grown in homogeneous conditions was demonstrated by showing characteristic behavioural differences which persist over their lifespans. Poissonian fluctuation of small numbers of generator molecules can explain this individuality and may apply to such processes as differentiation and asynchrony of cultures.

[1]  M. Delbrück.  The Burst Size Distribution in the Growth of Bacterial Viruses (Bacteriophages) , 1945, Journal of bacteriology.

[2]  B. Stocker,et al.  Measurements of rate of mutation of flagellar antigenic phase in Salmonella typhi-murium , 1949, Epidemiology and Infection.

[3]  S. Benzer,et al.  Induced synthesis of enzymes in bacteria analyzed at the cellular level. , 1953, Biochimica et biophysica acta.

[4]  The inheritance of differences in growth rate in Escherichia coli. , 1955, Journal of general microbiology.

[5]  J Lederberg,et al.  Phase Variation in Salmonella. , 1956, Genetics.

[6]  A. Novick,et al.  ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON. , 1957, Proceedings of the National Academy of Sciences of the United States of America.

[7]  E. Powell.  An outline of the pattern of bacterial generation times. , 1958, Journal of general microbiology.

[8]  R. Stanier,et al.  The Bacteria: A treatise on structure and function. Vol. Ill: Biosynthesis. Vol. IY: The physiology of growth. , 1960 .

[9]  A. Wilson,et al.  Regulation of flavin synthesis by Escherichia coli. , 1962, Journal of General Microbiology.

[10]  A. L. Koch,et al.  Growth, cell and nuclear divisions in some bacteria. , 1962, Journal of general microbiology.

[11]  D. F. Petersen,et al.  Quantity Production of Synchronized Mammalian Cells in Suspension Culture , 1964, Nature.

[12]  W. Gilbert,et al.  The lac operator is DNA. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[13]  C. Yanofsky,et al.  Transcription Initiation Frequency for the Tryptophan Operon of Escherichia coli , 1970 .

[14]  H. Berg,et al.  Chemotaxis in Escherichia coli analysed by Three-dimensional Tracking , 1972, Nature.

[15]  R. Macnab,et al.  The gradient-sensing mechanism in bacterial chemotaxis. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J. Smith,et al.  Do cells cycle? , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[17]  D E Koshland,et al.  Common Mechanism for Repellents and Attractants in Bacterial Chemotaxis , 1973, Science.

[18]  P. Maloney,et al.  Distribution of suboptimally induces -D-galactosidase in Escherichia coli. The enzyme content of individual cells. , 1973, Journal of molecular biology.

[19]  D. Brown,et al.  Temporal stimulation of chemotaxis in Escherichia coli. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Adler,et al.  Change in direction of flagellar rotation is the basis of the chemotactic response in Escherichia coli , 1974, Nature.

[21]  D. Koshland,et al.  Role of Methionine in Bacterial Chemotaxis , 1974, Journal of bacteriology.

[22]  M. Simon,et al.  Flagellar rotation and the mechanism of bacterial motility , 1974, Nature.

[23]  P. D. MINOR,et al.  Explanation of Degree of Correlation of Sibling Generation Times in Animal Cells , 1974, Nature.

[24]  William F. Loomis,et al.  Dictyostelium discoideum: A Developmental System , 1977 .

[25]  H. Berg,et al.  Transient response to chemotactic stimuli in Escherichia coli. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[26]  D. Koshland,et al.  Quantitation of the sensory response in bacterial chemotaxis. , 1975, Proceedings of the National Academy of Sciences of the United States of America.