Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice

[1]  T. Saheki,et al.  Attenuation of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice achieved by lowering dietary lipid. , 2006, Journal of biochemistry.

[2]  A. Thorpe,et al.  Orexin A in the nucleus accumbens stimulates feeding and locomotor activity , 2005, Brain Research.

[3]  T. Horvath,et al.  Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. , 2005, Cell metabolism.

[4]  T. Sakurai,et al.  Orexin Neurons Function in an Efferent Pathway of a Food-Entrainable Circadian Oscillator in Eliciting Food-Anticipatory Activity and Wakefulness , 2004, The Journal of Neuroscience.

[5]  T. Scammell,et al.  Behavioral state instability in orexin knockout mice , 2004, The Journal of Neuroscience.

[6]  Masaaki Tanaka,et al.  Role of acetyl-L-carnitine in the brain: revealed by Bioradiography. , 2003, Biochemical and biophysical research communications.

[7]  Jon T. Willie,et al.  Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes , 2003, Neuron.

[8]  Takeshi Sakurai,et al.  Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System , 2002, Neuron.

[9]  T. Saheki,et al.  Hyperammonemia in Carnitine-Deficient Adult JVS Mice Caused by Starvation , 2002, Metabolic Brain Disease.

[10]  H. Ohtsu,et al.  Increased methamphetamine‐induced locomotor activity and behavioral sensitization in histamine‐deficient mice , 2002, Journal of neurochemistry.

[11]  S. Nakagawa,et al.  Effect of enucleation on the expression of c-Fos protein in the supraoptic nucleus of the Japanese monkey (Macaca fuscata) , 2002, Brain Research.

[12]  H. Ohtsu,et al.  Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep–Wake Control , 2002, The Journal of Neuroscience.

[13]  B. Beck,et al.  Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects , 2002, Regulatory Peptides.

[14]  J. Levine,et al.  Feeding and activity induced by orexin A in the lateral hypothalamus in rats , 2002, Regulatory Peptides.

[15]  J. Denburg,et al.  Neurotoxic properties of cerebrospinal fluid from behaviorally impaired autoimmune mice , 2001, Brain Research.

[16]  Y. Urade,et al.  Arousal effect of orexin A depends on activation of the histaminergic system , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Jon T. Willie,et al.  Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity , 2001, Neuron.

[18]  E. Mignot,et al.  Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation , 2001, Neuroreport.

[19]  C. Saper,et al.  Fos Expression in Orexin Neurons Varies with Behavioral State , 2001, The Journal of Neuroscience.

[20]  I. Sora,et al.  Dopaminergic Role in Stimulant-Induced Wakefulness , 2001, The Journal of Neuroscience.

[21]  G. Yoshimichi,et al.  Orexin-A Regulates Body Temperature in Coordination with Arousal Status , 2001, Experimental biology and medicine.

[22]  T. Saheki,et al.  Antagonizing effect of AP-1 on glucocorticoid induction of urea cycle enzymes: a study of hyperammonemia in carnitine-deficient, juvenile visceral steatosis mice. , 2000, Molecular genetics and metabolism.

[23]  J. Sutcliffe,et al.  The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding , 2000, Journal of neuroscience research.

[24]  T. Sakurai,et al.  Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published on the World Wide Web on 27 June 2000. , 2000, Brain Research.

[25]  Jon T. Willie,et al.  Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation , 1999, Cell.

[26]  D. Rabier,et al.  Recognition and management of fatty acid oxidation defects: A series of 107 patients , 1999, Journal of Inherited Metabolic Disease.

[27]  A Stricker-Krongrad,et al.  Independent feeding and metabolic actions of orexins in mice. , 1998, Biochemical and biophysical research communications.

[28]  H. Nishimori,et al.  A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. , 1998, Biochemical and biophysical research communications.

[29]  J. Nezu,et al.  Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2* , 1998, The Journal of Biological Chemistry.

[30]  S. Carr,et al.  Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior , 1998, Cell.

[31]  T. Saheki,et al.  Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice. , 1997, Biochimica et biophysica acta.

[32]  T. Saheki,et al.  The Effect of Carnitine on Ketogenesis in Perfused Livers from Juvenile Visceral Steatosis Mice with Systemic Carnitine Deficiency , 1997, Pediatric Research.

[33]  T. Deboer,et al.  Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice , 1997, The Journal of Neuroscience.

[34]  R. Pollitt.  Disorders of mitochondrial long-chain fatty acid oxidation , 1995, Journal of Inherited Metabolic Disease.

[35]  M. Nomoto,et al.  Involvement of N-methyl-D-aspartate (NMDA) receptors in noncompetitive NMDA receptor antagonist-induced hyperlocomotion in mice , 1995, Pharmacology Biochemistry and Behavior.

[36]  T. Saheki,et al.  Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system. , 1994, Biochimica et biophysica acta.

[37]  T. Saheki,et al.  Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency , 1993, FEBS letters.

[38]  A. Lajtha,et al.  Effect of acetyl-l-carnitine on extracellular amino acid levels in vivo in rat brain regions , 1993, Neurochemical Research.

[39]  T. Saheki,et al.  Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription. , 1992, The Journal of biological chemistry.

[40]  J. Miyazaki,et al.  Rapid identification of transgenic mice with PCR amplification of DNA from ear punching , 1991 .

[41]  T. Saheki,et al.  Animal model of systemic carnitine deficiency: Analysis in C3H-H-2° strain of mouse associated with juvenile visceral steatosis , 1991 .

[42]  T. Saheki,et al.  Urea cycle disorder in C3H‐H‐2° mice with juvenile steatosis of viscera , 1990 .

[43]  A. Nonomura,et al.  Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2° strain of mouse with similarities to Reye's syndrome , 1988, Laboratory animals.

[44]  G. Tsujimoto,et al.  Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter , 1999, Nature Genetics.

[45]  T. Saheki,et al.  Suppressed expression of the urea cycle enzyme genes in the liver of carnitine-deficient juvenile visceral steatosis (JVS) mice in infancy and during starvation in adulthood. , 1997, Journal of biochemistry.

[46]  R. Fish.  Pharmacology of Injectable Anesthetics , 1997 .