Short-term associations of cause-specific emergency hospitalizations and particulate matter chemical components in Hong Kong.

Despite an increasing number of recent studies, the overall epidemiologic evidence associating specific particulate matter chemical components with health outcomes has been mixed. The links between components and hospitalizations have rarely been examined in Asia. We estimated associations between exposures to 18 chemical components of particulate matter with aerodynamic diameter less than 10 μm (PM10) and daily emergency cardiorespiratory hospitalizations in Hong Kong, China, between 2001 and 2007. Carbonaceous particulate matter, sulfate, nitrate, and ammonium accounted for two-thirds of the PM10 mass. After adjustment for time-varying confounders, a 3.4-μg/m(3) increment in 2-day moving average of same-day and previous-day nitrate concentrations was associated with the largest increase of 1.32% (95% confidence interval: 0.73, 1.92) in cardiovascular hospitalizations; elevation in manganese level (0.02 μg/m(3)) was linked to a 0.91% (95% confidence interval: 0.19, 1.64) increase in respiratory hospitalizations. Upon further adjustment for gaseous copollutants, nitrate, sodium ion, chloride ion, magnesium, and nickel remained significantly associated with cardiovascular hospitalizations, whereas sodium ion, aluminum, and magnesium, components abundantly found in coarser PM10, were associated with respiratory hospitalizations. Most positive links were seen during the cold season. These findings lend support to the growing body of literature concerning the health associations of particulate matter composition and provide important insight into the differential health risks of components found in fine and coarse modes of PM10.

[1]  Hong Qiu,et al.  Differential effects of fine and coarse particles on daily emergency cardiovascular hospitalizations in Hong Kong , 2013 .

[2]  O. Raaschou-Nielsen,et al.  Ambient particle source apportionment and daily hospital admissions among children and elderly in Copenhagen , 2006, Journal of Exposure Science and Environmental Epidemiology.

[3]  Alexis K.H. Lau,et al.  Long-term trends of ambient particulate matter emission source contributions and the accountability of control strategies in Hong Kong over 1998–2008 , 2013 .

[4]  V. Wagner,et al.  Short-term associations between fine and coarse particles and hospital admissions for cardiorespiratory diseases in six French cities , 2007, Occupational and Environmental Medicine.

[5]  P. Paatero,et al.  PM source apportionment and health effects: 1. Intercomparison of source apportionment results , 2006, Journal of Exposure Science and Environmental Epidemiology.

[6]  P. Hopke,et al.  Fine Particle Sources and Cardiorespiratory Morbidity: An Application of Chemical Mass Balance and Factor Analytical Source-Apportionment Methods , 2008, Environmental health perspectives.

[7]  Kazuhiko Ito,et al.  PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ , 2006, Journal of Exposure Science and Environmental Epidemiology.

[8]  Ulrich Pöschl,et al.  Atmospheric aerosols: composition, transformation, climate and health effects. , 2005, Angewandte Chemie.

[9]  R. Tibshirani,et al.  Generalized Additive Models , 1986 .

[10]  B. Ostro,et al.  The Effects of Fine Particle Components on Respiratory Hospital Admissions in Children , 2008, Environmental health perspectives.

[11]  Ki-Hyun Kim,et al.  Characterization of Fine Particulate Matter and Associations between Particulate Chemical Constituents and Mortality in Seoul, Korea , 2012, Environmental health perspectives.

[12]  Kurt Hornik,et al.  A CLUE for CLUster Ensembles , 2005 .

[13]  Gary W. Fuller,et al.  Urban Ambient Particle Metrics and Health: A Time-series Analysis , 2010, Epidemiology.

[14]  Scott L. Zeger,et al.  Spatial and Temporal Variation in PM2.5 Chemical Composition in the United States for Health Effects Studies , 2007, Environmental health perspectives.

[15]  W. Malm,et al.  Observations of fine and coarse particle nitrate at several rural locations in the United States , 2008 .

[16]  Julia C. Fussell,et al.  Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter , 2012 .

[17]  Kazuhiko Ito,et al.  Distributed Lag Analyses of Daily Hospital Admissions and Source-Apportioned Fine Particle Air Pollution , 2010, Environmental health perspectives.

[18]  Kazuhiko Ito,et al.  Spatial variation of PM2.5 chemical species and source-apportioned mass concentrations in New York City , 2004 .

[19]  A. Zeileis,et al.  zoo: S3 Infrastructure for Regular and Irregular Time Series , 2005, math/0505527.

[20]  Xiaohui Xu,et al.  Differentiating the associations of black carbon and fine particle with daily mortality in a Chinese city. , 2013, Environmental research.

[21]  Francesca Dominici,et al.  Hospital admissions and chemical composition of fine particle air pollution. , 2009, American journal of respiratory and critical care medicine.

[22]  Kazuhiko Ito,et al.  Time-Series Analysis of Mortality Effects of Fine Particulate Matter Components in Detroit and Seattle , 2010, Environmental health perspectives.

[23]  Y. Lau,et al.  Association between air pollution and asthma admission among children in Hong Kong , 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[24]  Petros Koutrakis,et al.  Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution , 2009, Environmental health perspectives.

[25]  T. Wong,et al.  Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong. , 1999, Occupational and environmental medicine.

[26]  Stefan Ma,et al.  A tale of two cities: effects of air pollution on hospital admissions in Hong Kong and London compared. , 2001, Environmental health perspectives.

[27]  Polina Maciejczyk,et al.  Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: VIII. Source-Related Daily Variations in In Vitro Responses to CAPs , 2005, Inhalation toxicology.

[28]  J. Schwartz,et al.  Elemental concentrations of ambient particles and cause specific mortality in Santiago, Chile: a time series study , 2012, Environmental Health.

[29]  Juhani Ruuskanen,et al.  Source-Specific Fine Particles in Urban Air and Respiratory Function Among Adult Asthmatics , 2006, Inhalation toxicology.

[30]  Qun Xu,et al.  Fine Particulate Matter Constituents and Cardiopulmonary Mortality in a Heavily Polluted Chinese City , 2012, Environmental health perspectives.

[31]  J. Schwartz,et al.  Association of fine particulate matter from different sources with daily mortality in six U.S. cities. , 2000, Environmental health perspectives.

[32]  J. Fung,et al.  Identification and spatiotemporal variations of dominant PM10 sources over Hong Kong , 2006 .

[33]  B. Ostro,et al.  The impact of components of fine particulate matter on cardiovascular mortality in susceptible subpopulations , 2008, Occupational and Environmental Medicine.

[34]  R. Dales,et al.  Components of Particulate Air Pollution and Emergency Department Visits in Chile , 2009, Archives of environmental & occupational health.

[35]  S. Wood.  Fast stable restricted maximum likelihood and marginal likelihood estimation of semiparametric generalized linear models , 2011 .

[36]  Kazuhiko Ito,et al.  Fine Particulate Matter Constituents Associated with Cardiovascular Hospitalizations and Mortality in New York City , 2010, Environmental health perspectives.

[37]  D Krewski,et al.  The role of particulate size and chemistry in the association between summertime ambient air pollution and hospitalization for cardiorespiratory diseases. , 1997, Environmental health perspectives.

[38]  Howard Frumkin,et al.  Ambient Air Pollution and Cardiovascular Emergency Department Visits , 2004, Epidemiology.

[39]  Michael Lipsett,et al.  The Effects of Components of Fine Particulate Air Pollution on Mortality in California: Results from CALFINE , 2006, Environmental health perspectives.

[40]  R. Wyzga,et al.  Air pollution and mortality: the implications of uncertainties in regression modeling and exposure measurement. , 1997, Journal of the Air & Waste Management Association.

[41]  A. Wexler,et al.  Formation of nitrate and non-sea-salt sulfate on coarse particles , 1999 .

[42]  L. Sheppard,et al.  Ambient Woodsmoke and Associated Respiratory Emergency Department Visits in Spokane, Washington , 2006, International journal of occupational and environmental health.

[43]  Wei Huang,et al.  Seasonal variation of chemical species associated with short-term mortality effects of PM(2.5) in Xi'an, a Central City in China. , 2012, American journal of epidemiology.

[44]  Richard Reiss,et al.  Evidence of Health Impacts of Sulfate-and Nitrate-Containing Particles in Ambient Air , 2007, Inhalation toxicology.

[45]  Antonella Zanobetti,et al.  Fine particulate air pollution and its components in association with cause-specific emergency admissions , 2009, Environmental health : a global access science source.

[46]  H. Kan,et al.  Shipping emissions associated with increased cardiovascular hospitalizations , 2013 .

[47]  F. Dominici,et al.  Emergency Admissions for Cardiovascular and Respiratory Diseases and the Chemical Composition of Fine Particle Air Pollution , 2009, Environmental health perspectives.

[48]  Fulvio Amato,et al.  The Effects of Particulate Matter Sources on Daily Mortality: A Case-Crossover Study of Barcelona, Spain , 2011, Environmental health perspectives.

[49]  LondJ.  Air quality reports , 2015 .

[50]  Haidong Kan,et al.  Public Health and Air Pollution in Asia (PAPA): A Multicity Study of Short-Term Effects of Air Pollution on Mortality , 2008, Environmental health perspectives.

[51]  Timo Lanki,et al.  Particulate Air Pollution and Acute Cardiorespiratory Hospital Admissions and Mortality Among the Elderly , 2009, Epidemiology.

[52]  A. Hedley,et al.  Effect of air pollution on daily mortality in Hong Kong. , 2001, Environmental health perspectives.

[53]  Hong Qiu,et al.  Effects of Coarse Particulate Matter on Emergency Hospital Admissions for Respiratory Diseases: A Time-Series Analysis in Hong Kong , 2012, Environmental health perspectives.

[54]  L. Sheppard,et al.  The Temporal Lag Structure of Short-term Associations of Fine Particulate Matter Chemical Constituents and Cardiovascular and Respiratory Hospitalizations , 2012, Environmental health perspectives.

[55]  Division on Earth.  Research priorities for airborne particulate matter , 2013 .

[56]  G. J. Wells,et al.  Tools for improving air quality management : a review of top-down source apportionment techniques and their application in developing countries , 2011 .