BRAPH 2.0: Software for the analysis of brain connectivity with graph theory

There is increasing evidence showing that graph theory is a promising tool to study the human brain connectome. By representing brain regions and their connections as nodes and edges, it allows assessing properties that reflect how well brain networks are organized and how they become disrupted in neurological diseases such as Alzheimer’s disease, Parkinson’s disease, epilepsy, schizophrenia, multiple sclerosis and autism. Here, we present BRAPH 2.0 (BRain Analysis using graPH theory version 2.0), which is a major update of the first object-oriented open source software written in Matlab for graph-theoretical analysis that also implements a graphical interface (GUI). BRAPH utilizes the capability of object-oriented programming paradigm to provide clear, robust, clean, modular, maintainable, and testable code.