Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways.

[1]  N. Ishihara,et al.  Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation. , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Q. Nie,et al.  LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B , 2021, Cell death discovery.

[3]  Xiaoling Chen,et al.  Quercetin regulates skeletal muscle fiber type switching via adiponectin signaling. , 2021, Food & function.

[4]  Yanping Wei,et al.  Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy , 2021, Frontiers in Pediatrics.

[5]  K. Mihara,et al.  MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity , 2020, Nature Communications.

[6]  L. Scorrano,et al.  The cell biology of mitochondrial membrane dynamics , 2020, Nature Reviews Molecular Cell Biology.

[7]  N. Ishihara,et al.  Mitochondrial nucleoid morphology and respiratory function are altered in Drp1-deficient HeLa cells. , 2019, Journal of biochemistry.

[8]  C. Di Resta,et al.  Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation. , 2019, Human molecular genetics.

[9]  L. Scorrano,et al.  DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass , 2019, Nature Communications.

[10]  J. Shrager,et al.  mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism , 2019, Aging cell.

[11]  S. Powers,et al.  Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects. , 2019, Archives of biochemistry and biophysics.

[12]  Xiaoling Chen,et al.  Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1/AMPK pathway. , 2018, The Journal of nutritional biochemistry.

[13]  Sharyn A. Lincoln,et al.  Aberrant Drp1‐mediated mitochondrial division presents in humans with variable outcomes , 2018, Human molecular genetics.

[14]  Byung-Ju Kim,et al.  Exercise induces muscle fiber type switching via transient receptor potential melastatin 2-dependent Ca2+ signaling. , 2018, Journal of applied physiology.

[15]  G. Dorn,et al.  Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. , 2017, Cell Metabolism.

[16]  Jie Tang,et al.  Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 , 2017, Nature.

[17]  T. Cash-Mason,et al.  GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates , 2017, Nature Medicine.

[18]  V. Velagapudi,et al.  mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression. , 2017, Cell metabolism.

[19]  H. Hakonarson,et al.  GDF15 is a heart‐derived hormone that regulates body growth , 2017, EMBO molecular medicine.

[20]  Nolan W. Kennedy,et al.  The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species. , 2017, Developmental cell.

[21]  David S. Wishart,et al.  Heatmapper: web-enabled heat mapping for all , 2016, Nucleic Acids Res..

[22]  F. Villarroya,et al.  GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction , 2016, PloS one.

[23]  Wenzhang Wang,et al.  Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes , 2015, Nature Medicine.

[24]  Prashant Mishra,et al.  Mitochondrial Dynamics is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization. , 2015, Cell metabolism.

[25]  Y. Fukumoto,et al.  Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders , 2015, Annals of neurology.

[26]  N. Chandel Evolution of Mitochondria as Signaling Organelles. , 2015, Cell metabolism.

[27]  L. Leinwand,et al.  Developmental myosins: expression patterns and functional significance , 2015, Skeletal Muscle.

[28]  Webster K. Cavenee,et al.  Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance , 2015, Proceedings of the National Academy of Sciences.

[29]  E. Clementi,et al.  Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation , 2015, Cell Death and Disease.

[30]  J. Hayashi,et al.  Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. , 2015, Biochemical and biophysical research communications.

[31]  Maki Maeda,et al.  Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development , 2014, Molecular and Cellular Biology.

[32]  Matt Kaeberlein,et al.  mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome , 2013, Science.

[33]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[34]  Joon-Young Park,et al.  Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation. , 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

[35]  M. Hall,et al.  mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology , 2013, Proceedings of the National Academy of Sciences.

[36]  K. Mihara,et al.  Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c , 2013, Proceedings of the National Academy of Sciences.

[37]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[38]  J. Nunnari,et al.  Mitochondria: In Sickness and in Health , 2012, Cell.

[39]  R. Youle,et al.  PINK1- and Parkin-mediated mitophagy at a glance , 2012, Journal of Cell Science.

[40]  M. Mayo,et al.  Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein* , 2011, The Journal of Biological Chemistry.

[41]  A. Yodh,et al.  O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling , 2011, Molecular and Cellular Biology.

[42]  E. Jacinto,et al.  mTOR complex 2 signaling and functions , 2011, Cell cycle.

[43]  S. Ghosh,et al.  Mitochondria in innate immune responses , 2011, Nature Reviews Immunology.

[44]  Luca Scorrano,et al.  Mitochondrial fission and remodelling contributes to muscle atrophy , 2010, The EMBO journal.

[45]  T. Prolla,et al.  Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations , 2010, Cell.

[46]  R. Youle,et al.  The role of mitochondria in apoptosis*. , 2009, Annual review of genetics.

[47]  Satoshi O. Suzuki,et al.  Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice , 2009, Nature Cell Biology.

[48]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[49]  W. D. Fairlie,et al.  Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1 , 2007, Nature Medicine.

[50]  J. McCaffery,et al.  Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum , 2007, Cell.

[51]  H. McBride,et al.  Mitochondria: More Than Just a Powerhouse , 2006, Current Biology.

[52]  D. Sabatini,et al.  Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. , 2006, Molecular cell.

[53]  Ralf Bartenschlager,et al.  Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus , 2005, Nature.

[54]  L. Paraoan,et al.  Identification, expression and functional characterization of the GRAL gene , 2005, Journal of neurochemistry.

[55]  Zhijian J. Chen,et al.  Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 , 2005, Cell.

[56]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[57]  M. Pericak-Vance,et al.  Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A , 2004, Nature Genetics.

[58]  M. Schrader,et al.  Dynamin-like Protein 1 Is Involved in Peroxisomal Fission* , 2003, The Journal of Biological Chemistry.

[59]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[60]  M. Zeviani,et al.  Mitochondrial disorders. , 2003, Current opinion in neurology.

[61]  Jie Chen,et al.  The Mammalian Target of Rapamycin Regulates C2C12 Myogenesis via a Kinase-independent Mechanism* , 2001, The Journal of Biological Chemistry.

[62]  J. Grosgeorge,et al.  Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy , 2000, Nature Genetics.

[63]  S. Bhattacharya,et al.  OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 , 2000, Nature Genetics.

[64]  M. McNiven,et al.  The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. , 1999, Molecular biology of the cell.

[65]  D. Wallace Mitochondrial diseases in man and mouse. , 1999, Science.

[66]  A. J. Harris,et al.  Neural control of the sequence of expression of myosin heavy chain isoforms in foetal mammalian muscles. , 1989, Development.