Functionalised gold nanoparticles for controlling pathogenic bacteria.

The increasing number of bacterial strains that are resistant to available pharmaceutical compounds is a vital issue for public health. Innovative approaches will be required to improve the methods for both diagnosis and destruction of these organisms. Here, we consider the possible role that can be played by technologies based on gold nanoparticles. Gold nanoparticles generally are considered to be biologically inert but can be engineered to possess chemical or photothermal functionality. A growing body of research is devoted to the potential use of these nanoparticles in the diagnosis and treatment of bacterial infections. The results are both promising and intriguing, and suggest a range of new strategies to identify, target or destroy pathogenic organisms.

[1]  Wei Lu,et al.  In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy , 2008, Molecular Cancer Therapeutics.

[2]  Vladimir P. Zharov,et al.  Photothermal detection of local thermal effects during selective nanophotothermolysis , 2003 .

[3]  L. Dykman,et al.  On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold Nanoparticles , 2009, Nanoscale research letters.

[4]  G. Woods,et al.  Times to Detection of Bacteria and Yeasts in BACTEC 9240 Blood Culture Bottles , 1999, Journal of Clinical Microbiology.

[5]  Vladimir P Zharov,et al.  Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy. , 2005, Nanomedicine : nanotechnology, biology, and medicine.

[6]  J. Fuchs,et al.  The role of oxygen in cutaneous photodynamic therapy. , 1998, Free radical biology & medicine.

[7]  Vincent M Rotello,et al.  Rapid and efficient identification of bacteria using gold-nanoparticle-poly(para-phenyleneethynylene) constructs. , 2008, Angewandte Chemie.

[8]  G. Mazerolles,et al.  Discrimination of Staphylococcus aureus strains from different species of Staphylococcus using Fourier transform infrared (FTIR) spectroscopy. , 2006, International journal of food microbiology.

[9]  P. Baptista,et al.  Gold-nanoparticle-probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples. , 2006, Clinical chemistry.

[10]  Nuria Sanvicens,et al.  Multifunctional nanoparticles--properties and prospects for their use in human medicine. , 2008, Trends in biotechnology.

[11]  S. Das,et al.  Gold nanoparticles: microbial synthesis and application in water hygiene management. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[12]  Jocelyne Bosson,et al.  Gold hollow spheres obtained using an innovative emulsion process: towards multifunctional Au nanoshells , 2009, Nanotechnology.

[13]  Tsung-Chou Chang,et al.  RAPID DETECTION of STAPHYLOCOCCUS AUREUS IN FOOD BY FLOW CYTOMETRY , 1992 .

[14]  Vincent M Rotello,et al.  Gold nanoparticles in delivery applications. , 2008, Advanced drug delivery reviews.

[15]  Anand Gole,et al.  Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods. , 2008, Nano letters.

[16]  D. P. O'Neal,et al.  Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. , 2004, Cancer letters.

[17]  G. Barratt,et al.  Colloidal drug carriers: achievements and perspectives , 2003, Cellular and Molecular Life Sciences CMLS.

[18]  V. Zharov,et al.  Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. , 2009, Nature nanotechnology.

[19]  Vladimir P Zharov,et al.  Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. , 2006, Biophysical journal.

[20]  W. Hotch A Shot in the Arm , 1972, Occupational health nursing.

[21]  R. Stafford,et al.  Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Roger Finch,et al.  Lack of development of new antimicrobial drugs: a potential serious threat to public health. , 2005, The Lancet. Infectious diseases.

[23]  V. Tuchin,et al.  Photothermal flow cytometry in vitro for detection and imaging of individual moving cells , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[24]  Dakrong Pissuwan,et al.  Targeted destruction of murine macrophage cells with bioconjugated gold nanorods , 2007 .

[25]  M. Leeb A shot in the arm , 2004 .

[26]  Vladimir P Zharov,et al.  Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy. , 2006, Nano letters.

[27]  J. West,et al.  Metal Nanoshells , 2005, Annals of Biomedical Engineering.

[28]  P. Couvreur,et al.  Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications. , 2000, International journal of antimicrobial agents.

[29]  Leon Hirsch,et al.  Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer , 2004, Technology in cancer research & treatment.

[30]  Q. Wei,et al.  Two-photon luminescence imaging of Bacillus spores using peptide-functionalized gold nanorods , 2008, Nano research.

[31]  Su-Hua Huang Gold nanoparticle-based immunochromatographic assay for the detection of Staphylococcus aureus , 2007 .

[32]  Prashant K. Jain,et al.  Plasmonic photothermal therapy (PPTT) using gold nanoparticles , 2008, Lasers in Medical Science.

[33]  Michael T. Wilson,et al.  Lethal photosensitisation of Staphylococcus aureus using a toluidine blue O-tiopronin-gold nanoparticle conjugate , 2007 .

[34]  Michael Wilson,et al.  Antibody-directed photodynamic therapy of methicillin resistant Staphylococcus aureus. , 2004, Microbial drug resistance.

[35]  Michael T. Wilson,et al.  The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. , 2009, Biomaterials.

[36]  Xunbin Wei,et al.  Selective cell targeting with light-absorbing microparticles and nanoparticles. , 2003, Biophysical journal.

[37]  M. A. Hayat,et al.  Colloidal Gold: Principles, Methods, and Applications , 2012 .

[38]  Benno Radt,et al.  Optically Addressable Nanostructured Capsules , 2004 .

[39]  Chufu Zhang,et al.  Visual DNA microarrays for simultaneous detection of Ureaplasma urealyticum and Chlamydia trachomatis coupled with multiplex asymmetrical PCR. , 2006, Biosensors & bioelectronics.

[40]  A. Grace,et al.  Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles- : A brief study , 2007 .

[41]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[42]  François Guillemin,et al.  Nanoparticles as vehicles for delivery of photodynamic therapy agents. , 2008, Trends in biotechnology.

[43]  M. Alagar,et al.  Analytical detection and biological assay of antileukemic drug 5-fluorouracil using gold nanoparticles as probe. , 2007, International journal of pharmaceutics.

[44]  O. Babalola Molecular techniques: An overview of methods for the detection of bacteria , 2003 .

[45]  Bing Xu,et al.  Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities , 2003 .

[46]  K. Tsuchida,et al.  Recent advances in inorganic nanoparticle-based drug delivery systems. , 2008, Mini reviews in medicinal chemistry.

[47]  A. Dasgupta,et al.  In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics , 2007, Nanoscale Research Letters.

[48]  T. Pradeep,et al.  Investigations of the antibacterial properties of ciprofloxacin@SiO2. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[49]  Younan Xia,et al.  Template-Engaged Replacement Reaction: A One-Step Approach to the Large-Scale Synthesis of Metal Nanostructures with Hollow Interiors , 2002 .

[50]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[51]  Christopher J. Destache,et al.  Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System , 2006, Journal of Neuroimmune Pharmacology.

[52]  Dakrong Pissuwan,et al.  Therapeutic possibilities of plasmonically heated gold nanoparticles. , 2006, Trends in biotechnology.

[53]  Jian Ji,et al.  The Escherichia coli O157:H7 DNA detection on a gold nanoparticle-enhanced piezoelectric biosensor , 2008 .

[54]  M. Carrière,et al.  Impact of gold nanoparticles combined to X-Ray irradiation on bacteria , 2008 .

[55]  Dakrong Pissuwan,et al.  Destruction and control of Toxoplasma gondii tachyzoites using gold nanosphere/antibody conjugates. , 2009, Small.

[56]  Dakrong Pissuwan,et al.  A golden bullet? Selective targeting of Toxoplasma gondii tachyzoites using antibody-functionalized gold nanorods. , 2007, Nano letters.

[57]  Yuan-chuan Lee,et al.  Carbohydrate-Protein Interactions: Basis of Glycobiology , 1995 .

[58]  A. C. Hunter,et al.  Nanomedicine: current status and future prospects , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[59]  Yu-Chie Chen,et al.  Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria. , 2007, Nanomedicine.

[60]  William Wiley Navarre,et al.  Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope , 1999, Microbiology and Molecular Biology Reviews.

[61]  Chen-Sheng Yeh,et al.  Antimicrobial gold nanorods with dual-modality photodynamic inactivation and hyperthermia. , 2009, Chemical communications.

[62]  Dakrong Pissuwan,et al.  Prospects for Gold Nanorod Particles in Diagnostic and Therapeutic Applications , 2008, Biotechnology & genetic engineering reviews.

[63]  Viswanadham Garimella,et al.  Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system. , 2004, Biosensors & bioelectronics.

[64]  T. Pradeep,et al.  Ciprofloxacin-protected gold nanoparticles. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[65]  W. Faulk,et al.  An immunocolloid method for the electron microscope. , 1971, Immunochemistry.

[66]  S. Valenzuela,et al.  Gold nanosphere-antibody conjugates for hyperthermal therapeutic applications , 2007 .