The role of exercise and PGC1α in inflammation and chronic disease

[1]  B. Spiegelman,et al.  Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation , 2008, Proceedings of the National Academy of Sciences.

[2]  A. Beekman,et al.  Inflammatory markers in late-life depression: results from a population-based study. , 2008, Journal of affective disorders.

[3]  Stuart L. Schreiber,et al.  Large-scale chemical dissection of mitochondrial function , 2008, Nature Biotechnology.

[4]  J Michael Gaziano,et al.  Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. , 2008, Archives of internal medicine.

[5]  J. Myers,et al.  Exercise Capacity and Mortality in Black and White Men , 2008, Circulation.

[6]  C. Cotman PL6.1 Keynote lecture: Exercise builds brain health: key roles of growth factor cascades and inflammation , 2008 .

[7]  L. Ji Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. , 2008, Free radical biology & medicine.

[8]  Jiandie D. Lin,et al.  Muscle-specific expression of PPAR (cid:1) coactivator-1 (cid:2) improves exercise performance and increases peak oxygen uptake , 2008 .

[9]  Terina N. Martinez,et al.  Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? , 2008, Frontiers in bioscience : a journal and virtual library.

[10]  C. Zechner,et al.  A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling* , 2007, Journal of Biological Chemistry.

[11]  Michiaki Yamashita,et al.  The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. , 2007, The Journal of clinical investigation.

[12]  Gerard King,et al.  Physical activity and the elderly , 2007, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[13]  R. Roubenoff Physical activity, inflammation, and muscle loss. , 2007, Nutrition reviews.

[14]  W. Brown,et al.  Updating the evidence on physical activity and health in women. , 2007, American journal of preventive medicine.

[15]  V. Mootha,et al.  Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk , 2007 .

[16]  Marc T. Hamilton,et al.  Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease , 2007, Diabetes.

[17]  B. Spiegelman,et al.  Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals* , 2007, Journal of Biological Chemistry.

[18]  G. Blackburn,et al.  Symposium introduction: metabolic syndrome and the onset of cancer. , 2007, The American journal of clinical nutrition.

[19]  Carl W. Cotman,et al.  Exercise builds brain health: key roles of growth factor cascades and inflammation , 2007, Trends in Neurosciences.

[20]  B. Pedersen,et al.  Role of myokines in exercise and metabolism. , 2007, Journal of applied physiology.

[21]  David R. Thomas,et al.  Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia. , 2007, Clinical nutrition.

[22]  M. Gleeson,et al.  Immune function in sport and exercise. , 2007, Journal of applied physiology.

[23]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[24]  Wan-Wan Lin,et al.  A cytokine-mediated link between innate immunity, inflammation, and cancer. , 2007, The Journal of clinical investigation.

[25]  J. Moylan,et al.  Oxidative stress, chronic disease, and muscle wasting , 2007, Muscle & nerve.

[26]  B. Spiegelman,et al.  PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy , 2007 .

[27]  P S Whitton,et al.  Inflammation as a causative factor in the aetiology of Parkinson's disease , 2007, British journal of pharmacology.

[28]  R. Jiles,et al.  Health Behaviors of the Young Adult U.S. Population: Behavioral Risk Factor Surveillance System, 2003 , 2007, Preventing chronic disease.

[29]  C. Matter,et al.  RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. , 2007, Circulation.

[30]  Colm Cunningham,et al.  Systemic infections and inflammation affect chronic neurodegeneration , 2007, Nature Reviews Immunology.

[31]  B. Spiegelman,et al.  The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. , 2007, Cell metabolism.

[32]  F. Booth,et al.  Fundamental questions about genes, inactivity, and chronic diseases. , 2007, Physiological genomics.

[33]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[34]  Jaipaul Singh,et al.  Inflammatory Process in Type 2 Diabetes , 2006 .

[35]  Jiandie D. Lin,et al.  PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription , 2006, Proceedings of the National Academy of Sciences.

[36]  Jiandie D. Lin,et al.  Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators , 2006, Cell.

[37]  Frauke Zipp,et al.  The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases , 2006, Trends in Neurosciences.

[38]  D. Hood,et al.  Coordination of metabolic plasticity in skeletal muscle , 2006, Journal of Experimental Biology.

[39]  U. Das Exercise and inflammation. , 2006, European heart journal.

[40]  B. Spiegelman,et al.  Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. , 2006, Endocrine reviews.

[41]  Devanand Sarkar,et al.  Molecular mechanisms of aging-associated inflammation. , 2006, Cancer letters.

[42]  Li Wang,et al.  Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older , 2006, Annals of Internal Medicine.

[43]  S. Haffner,et al.  The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. , 2006, The American journal of cardiology.

[44]  Jaipaul Singh,et al.  Inflammatory process in type 2 diabetes: The role of cytokines. , 2006, Annals of the New York Academy of Sciences.

[45]  M. Gleeson,et al.  Exercise and Toll-like receptors. , 2006, Exercise immunology review.

[46]  T. Mandrup-Poulsen,et al.  Interleukin-6 and diabetes: the good, the bad, or the indifferent? , 2005, Diabetes.

[47]  M. Molinaro,et al.  Tumor necrosis factor‐α gene transfer induces cachexia and inhibits muscle regeneration , 2005 .

[48]  D. Glass,et al.  Skeletal muscle hypertrophy and atrophy signaling pathways. , 2005, The international journal of biochemistry & cell biology.

[49]  V. Mootha,et al.  Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes , 2005 .

[50]  Christoph Handschin,et al.  Metabolic control through the PGC-1 family of transcription coactivators. , 2005, Cell metabolism.

[51]  M. Monsalve,et al.  PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells , 2005 .

[52]  D. Cooper,et al.  IL-6-induced skeletal muscle atrophy. , 2005, Journal of applied physiology.

[53]  J. Manson,et al.  Adiposity as compared with physical activity in predicting mortality among women. , 2005, The New England journal of medicine.

[54]  Xiaohui S. Xie,et al.  Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle , 2004 .

[55]  A. Russell,et al.  Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. , 2003, Diabetes.

[56]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[57]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Henriette Pilegaard,et al.  Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle , 2003, The Journal of physiology.

[59]  D. Nieman Current perspective on exercise immunology , 2003, Current sports medicine reports.

[60]  H. Hoppeler,et al.  Molecular basis of skeletal muscle plasticity--from gene to form and function. , 2003, Reviews of physiology, biochemistry and pharmacology.

[61]  Jiandie D. Lin,et al.  Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres , 2002, Nature.

[62]  S. Gordon,et al.  Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy. , 2002, Journal of applied physiology.

[63]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002 .

[64]  G. Fraser,et al.  Ten years of life: Is it a matter of choice? , 2001, Archives of internal medicine.

[65]  D. Pette Historical Perspectives: plasticity of mammalian skeletal muscle. , 2001, Journal of applied physiology.

[66]  H. Brinkmeier,et al.  Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. , 2000, Physiological reviews.

[67]  L. Pérusse,et al.  Genotype-environment interaction in human obesity. , 2009, Nutrition reviews.

[68]  G A Colditz,et al.  A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. , 1999, The New England journal of medicine.

[69]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[70]  B. Pedersen,et al.  Exercise, nutrition and immune function. , 1999, Journal of sports sciences.

[71]  J. Rippe,et al.  The role of physical activity in the prevention and management of obesity. , 1998, Journal of the American Dietetic Association.

[72]  K. Liestøl,et al.  Changes in physical fitness and changes in mortality , 1998, The Lancet.

[73]  W. Zhu,et al.  A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. , 1998, Genes & development.

[74]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[75]  M. Elder The Role of Cytokines , 1997 .

[76]  B. Spiegelman,et al.  Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. , 1995, The Journal of clinical investigation.

[77]  B. Spiegelman,et al.  Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link , 1994, Diabetes.

[78]  B. Spiegelman,et al.  Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. , 1994, Endocrinology.

[79]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.

[80]  A. Buller,et al.  Plasticity in mammalian skeletal muscle. , 1977, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.