Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs.

[1]  G. Carrier,et al.  Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues. , 1995, Toxicology and applied pharmacology.

[2]  M E Andersen,et al.  Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment. , 1994, Environmental health perspectives.

[3]  M E Andersen,et al.  Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment. , 1993, Risk analysis : an official publication of the Society for Risk Analysis.

[4]  H W Leung,et al.  Development and utilization of physiologically based pharmacokinetic models for toxicological applications. , 1991, Journal of toxicology and environmental health.

[5]  M E Andersen,et al.  Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. , 1990, Toxicology and applied pharmacology.

[6]  F. A. Smith,et al.  Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. , 1987, Toxicology and applied pharmacology.

[7]  H J Clewell,et al.  Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. , 1986, Toxicology and applied pharmacology.

[8]  R K Jain,et al.  Physiologically based pharmacokinetic modeling: principles and applications. , 1983, Journal of pharmaceutical sciences.

[9]  L S Birnbaum,et al.  Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species. , 1983, Toxicology and applied pharmacology.

[10]  R. Lutz,et al.  A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. , 1977, Drug metabolism and disposition: the biological fate of chemicals.

[11]  V. Fiserova-Bergerova,et al.  Mathematical modeling of inhalation exposure , 1976 .

[12]  D. S. Riggs.  The Mathematical Approach to Physiological Problems: A Critical Primer , 1964 .

[13]  S. Kety.  The theory and applications of the exchange of inert gas at the lungs and tissues. , 1951, Pharmacological reviews.

[14]  H. Haggard,et al.  THE ABSORPTION, DISTRIBUTION, AND ELIMINATION OF ETHYL ETHER II. ANALYSIS OF THE MECHANISM OF ABSORPTION AND ELIMINATION OF SUCH A GAS OR VAPOR AS ETHYL ETHER , 1924 .

[15]  J. Kissel,et al.  Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model , 1988 .

[16]  W W MAPLESON,et al.  An electric analogue for uptake and exchange of inert gases and other agents. , 1963, Journal of applied physiology.

[17]  Torsten Teorell,et al.  Kinetics of distribution of substances administered to the body, II : The intravascular modes of administration , 1937 .