Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

Abstract Background. The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients. Methods. Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. Results. A total of 1109 women, ≤50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% ≥2 FDR. The three groups, none, 1 or ≥2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05–0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4–0.9). Conclusion. A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.

[1]  J. Nortier,et al.  The prognostic relevance of the mitotic activity index in axillary lymph node-negative breast cancer , 2014, Breast Cancer Research and Treatment.

[2]  Bernard Asselain,et al.  Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature , 2010, Breast Cancer Research and Treatment.

[3]  R. Wolfe,et al.  The relationship between knowledge of family history and cancer characteristics at diagnosis in women newly-diagnosed with invasive breast cancer , 2009, Familial Cancer.

[4]  A. Whittemore,et al.  Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry , 2009, Breast Cancer Research and Treatment.

[5]  K. Hemminki,et al.  Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk. , 2007, Cancer research.

[6]  G. Hortobagyi,et al.  Breast-conservation therapy in early-stage breast cancer patients with a positive family history , 2002, Annals of Surgical Oncology.

[7]  Nazneen Rahman,et al.  The emerging landscape of breast cancer susceptibility , 2007, Nature Genetics.

[8]  K. Hemminki,et al.  Risk for contralateral breast cancers in a population covered by mammography: effects of family history, age at diagnosis and histology , 2007, Breast Cancer Research and Treatment.

[9]  I. Andrulis,et al.  Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study , 2007, Breast Cancer Research and Treatment.

[10]  F. Wiklund,et al.  High risk of contralateral breast carcinoma in women with hereditary/familial non‐BRCA1/BRCA2 breast carcinoma , 2006, Cancer.

[11]  G. Vlastos,et al.  Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study , 2005, British Journal of Cancer.

[12]  Dominique Stoppa-Lyonnet,et al.  Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy. , 2005, European journal of cancer.

[13]  Kristine Broglio,et al.  Women age < or = 35 years with primary breast carcinoma: disease features at presentation. , 2005, Cancer.

[14]  Matthias W. Beckmann,et al.  Hereditary breast and ovarian cancer: review and future perspectives , 2005, Journal of Molecular Medicine.

[15]  T. Kinoshita,et al.  Prognosis of Breast Cancer Patients with Familial History Classified According to Their Menopausal Status , 2004, The breast journal.

[16]  D. Eccles,et al.  Familial breast cancer: an investigation into the outcome of treatment for early stage disease , 2004, Familial Cancer.

[17]  J. Klijn,et al.  The impact of having relatives affected with breast cancer on psychological distress in women at increased risk for hereditary breast cancer , 2004, Breast Cancer Research and Treatment.

[18]  F. Ong,et al.  The value of a positive margin for invasive carcinoma in breast-conservative treatment in relation to local recurrence is limited to young women only. , 2003, International journal of radiation oncology, biology, physics.

[19]  N Urban,et al.  Breast cancer worry and mammography use by women with and without a family history in a population-based sample. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[20]  R. Goldbohm,et al.  Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease , 2001, The Lancet.

[21]  J. van der Palen,et al.  Family history in breast cancer is not a prognostic factor? , 2000, Breast.

[22]  S. Seal,et al.  Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. , 1999, Journal of the National Cancer Institute.

[23]  J. Coebergh,et al.  Family history of breast cancer and local recurrence after breast-conserving therapy. The Dutch Study Group on Local Recurrence after Breast Conservation (BORST). , 1998, European journal of cancer.

[24]  D. Miles,et al.  Family history and survival in premenopausal breast cancer. , 1998, British Journal of Cancer.

[25]  N. Day,et al.  Family history and the risk of breast cancer: A systematic review and meta‐analysis , 1997, International journal of cancer.

[26]  E. White,et al.  Family history and survival of young women with invasive breast carcinoma , 1996, Cancer.