Targeting p53-dependent stem cell loss for intestinal chemoprotection
暂无分享,去创建一个
Jian Yu | R. Schoen | Lin Zhang | J. Beumer | J. Eiseman | J. Yu | R. Parise | M. Rachid | Liheng Yang | M. Buchanan | B. Leibowitz | Liang Wei
[1] W. El-Deiry,et al. Faculty Opinions recommendation of Targeting p53-dependent stem cell loss for intestinal chemoprotection. , 2018 .
[2] Jian Yu,et al. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. , 2016, The Journal of clinical investigation.
[3] Toshiro Sato,et al. Efficient genetic engineering of human intestinal organoids using electroporation , 2015, Nature Protocols.
[4] Linheng Li,et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation , 2015, Scientific Reports.
[5] M. Hauer-Jensen,et al. Radiation enteropathy—pathogenesis, treatment and prevention , 2014, Nature Reviews Gastroenterology &Hepatology.
[6] C. Taniguchi,et al. PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2 , 2014, Science Translational Medicine.
[7] G. Doherty,et al. Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation. , 2014, World journal of gastroenterology.
[8] Jian Yu,et al. Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice , 2014, Nature Communications.
[9] F. D. de Sauvage,et al. Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. , 2014, Cell stem cell.
[10] Jian Yu,et al. Role of Apoptosis in Colon Cancer Biology, Therapy, and Prevention , 2013, Current Colorectal Cancer Reports.
[11] J. Geng,et al. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection , 2013, Nature.
[12] Jian Yu,et al. Intestinal stem cell injury and protection during cancer therapy. , 2013, Translational cancer research.
[13] L. Zhang,et al. ADAR1 is essential for intestinal homeostasis and stem cell maintenance , 2013, Cell Death and Disease.
[14] Alexander van Oudenaarden,et al. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. , 2012, Cell stem cell.
[15] Matthias Stelzner,et al. A nomenclature for intestinal in vitro cultures. , 2012, American journal of physiology. Gastrointestinal and liver physiology.
[16] M. Berbée,et al. Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? , 2012, Current opinion in supportive and palliative care.
[17] P. Dempsey,et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells , 2012, Development.
[18] Hans Clevers,et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. , 2011, Gastroenterology.
[19] Jian Yu,et al. PUMA–mediated apoptosis drives chemical hepatocarcinogenesis in mice , 2011, Hepatology.
[20] Jian Yu,et al. p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. , 2011, Gastroenterology.
[21] Jian Yu,et al. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. , 2011, The Journal of clinical investigation.
[22] Jian Yu,et al. Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21 , 2011, Molecular Cancer Research.
[23] Ivet Bahar,et al. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. , 2011, Current topics in medicinal chemistry.
[24] M. Wong,et al. Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. , 2010, Gastroenterology.
[25] Jian Yu,et al. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis , 2010, Proceedings of the National Academy of Sciences.
[26] G. Krumschnabel,et al. Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. , 2010, Genes & development.
[27] A. Strasser,et al. Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. , 2010, Genes & development.
[28] A. Gudkov,et al. Pathologies associated with the p53 response. , 2010, Cold Spring Harbor perspectives in biology.
[29] W. Voigt,et al. Review: Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management , 2010, Therapeutic advances in medical oncology.
[30] Jian Yu,et al. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis , 2009, Oncogene.
[31] S. Korsmeyer,et al. p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis , 2009, Science.
[32] Jian Yu,et al. PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis , 2009, Cell Death and Differentiation.
[33] C. Prives,et al. Blinded by the Light: The Growing Complexity of p53 , 2009, Cell.
[34] Jian Yu,et al. PUMA, a potent killer with or without p53 , 2008, Oncogene.
[35] Jian Yu,et al. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. , 2008, Blood.
[36] Jian Yu,et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. , 2008, Cell stem cell.
[37] Jian Yu,et al. Chemosensitization of head and neck cancer cells by PUMA , 2007, Molecular Cancer Therapeutics.
[38] H. Clevers,et al. Tracking down the stem cells of the intestine: strategies to identify adult stem cells. , 2007, Gastroenterology.
[39] H. Clevers,et al. Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.
[40] S. Cory,et al. The Bcl-2 apoptotic switch in cancer development and therapy , 2007, Oncogene.
[41] A. Prabowo,et al. Role of p53 in irinotecan-induced intestinal cell death and mucosal damage , 2007, Anti-cancer drugs.
[42] Jian Yu,et al. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia–reperfusion , 2006, Gut.
[43] Peng Wang,et al. PUMA Dissociates Bax and Bcl-XL to Induce Apoptosis in Colon Cancer Cells* , 2006, Journal of Biological Chemistry.
[44] Jian Yu,et al. PUMA Sensitizes Lung Cancer Cells to Chemotherapeutic Agents and Irradiation , 2006, Clinical Cancer Research.
[45] Jian Yu,et al. The transcriptional targets of p53 in apoptosis control. , 2005, Biochemical and biophysical research communications.
[46] K. Kinzler,et al. Cancer genes and the pathways they control , 2004, Nature Medicine.
[47] J. Goldblum,et al. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice , 2004, Oncogene.
[48] Andreas Villunger,et al. p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa , 2003, Science.
[49] J. Cleveland,et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. , 2003, Cancer cell.
[50] K. Kinzler,et al. PUMA mediates the apoptotic response to p53 in colorectal cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[51] K. Kinzler,et al. PUMA induces the rapid apoptosis of colorectal cancer cells. , 2001, Molecular cell.
[52] A. Cummins,et al. Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans , 2000, Gut.
[53] K. Kinzler,et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. , 1998, Science.
[54] M Nomura,et al. Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. , 1996, Cancer research.
[55] P. Vrignaud,et al. Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice , 1996, Anti-cancer drugs.
[56] B. Calabretta,et al. Wild-type p53 differentially affects tumorigenic and metastatic potential of murine metastatic cell variants , 1993, Clinical & Experimental Metastasis.
[57] M. Iigo,et al. Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 , 1993, Japanese journal of cancer research : Gann.
[58] L. Donehower,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.
[59] H. Kuga,et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. , 1991, Cancer research.
[60] T. Tanaka,et al. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors. , 1987, Cancer research.
[61] D. Tousoulis,et al. The Role of Inflammation , 2018 .
[62] Jian Yu,et al. DNA Damage and Cellular Stress Responses Uncoupling p 53 Functions in Radiation-Induced Intestinal Damage via PUMA and p 21 , 2011 .