The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up
暂无分享,去创建一个
[1] P. Pattabiraman,et al. Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway , 2021, Cells.
[2] P. Codogno,et al. Links between autophagy and tissue mechanics. , 2021, Journal of cell science.
[3] Nektarios Tavernarakis,et al. Autophagy in healthy aging and disease , 2021, Nature Aging.
[4] Weijing Kong,et al. Glaucoma in mucopolysaccharidoses , 2021, Orphanet Journal of Rare Diseases.
[5] M. Coletta,et al. Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis , 2021, International journal of molecular sciences.
[6] Wei Zhu,et al. Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice , 2021, Molecular vision.
[7] Jonathan D. Smith,et al. Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function , 2021, Scientific Reports.
[8] M. Shim,et al. Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells , 2021, Proceedings of the National Academy of Sciences.
[9] J. Salazar,et al. The Role of Autophagy in Eye Diseases , 2021, Life.
[10] V. Sheffield,et al. Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin , 2021, JCI insight.
[11] M. Hébert,et al. Autophagy, tissue repair, and fibrosis: a delicate balance. , 2021, Matrix biology : journal of the International Society for Matrix Biology.
[12] M. Shim,et al. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma , 2020, Journal of clinical medicine.
[13] M. Cattaneo,et al. Autophagy in the Regulation of Tissue Differentiation and Homeostasis , 2020, Frontiers in Cell and Developmental Biology.
[14] Michael L. De Ieso,et al. Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow , 2020, The Journal of physiology.
[15] Ruikang K. Wang,et al. Aqueous outflow regulation – 21st century concepts , 2020, Progress in Retinal and Eye Research.
[16] N. Mizushima,et al. Autophagy in Human Diseases. , 2020, The New England journal of medicine.
[17] P. Codogno,et al. Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium-dependent lipophagy and mitochondria biogenesis. , 2020, Autophagy.
[18] J. Vranka,et al. Normal and glaucomatous outflow regulation , 2020, Progress in Retinal and Eye Research.
[19] M. Shim,et al. Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model , 2020, Investigative ophthalmology & visual science.
[20] M. Ke,et al. Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice , 2020, Frontiers in Pharmacology.
[21] M. Shim,et al. The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress , 2020, Autophagy.
[22] D. Gutterman,et al. Vascular autophagy in health and disease , 2020, Basic Research in Cardiology.
[23] F. Forouzandeh,et al. SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence , 2020, Autophagy.
[24] Md. Abdul Alim Al-Bari. A current view of molecular dissection in autophagy machinery , 2020, Journal of Physiology and Biochemistry.
[25] T. Choi,et al. Roles of Autophagy in Oxidative Stress , 2020, International journal of molecular sciences.
[26] Yang Sun,et al. Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation , 2020, Science Advances.
[27] W. Stamer,et al. Shear Stress in Schlemm’s Canal as a Sensor of Intraocular Pressure , 2020, Scientific Reports.
[28] Neena Singh,et al. TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology , 2020, Investigative ophthalmology & visual science.
[29] P. Codogno,et al. Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress , 2020, Autophagy.
[30] R. Yao,et al. Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles , 2020, Autophagy.
[31] N. Kalupahana,et al. Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system , 2020, Cell Death & Disease.
[32] D. Sabatini,et al. mTOR at the nexus of nutrition, growth, ageing and disease , 2020, Nature Reviews Molecular Cell Biology.
[33] Jen-Hung Wang,et al. Anterior Chamber Angles in Different Types of Mucopolysaccharidoses. , 2020, American journal of ophthalmology.
[34] M. Graef,et al. Mechanisms of Autophagy in Metabolic Stress Response. , 2020, Journal of molecular biology.
[35] N. Mizushima. The ATG conjugation systems in autophagy. , 2019, Current opinion in cell biology.
[36] Xiaorui Zhao,et al. Autophagy and Age-Related Eye Diseases , 2019, BioMed research international.
[37] Neena Singh,et al. Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications. , 2019, Experimental eye research.
[38] M. Shim,et al. Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells , 2019, Scientific Reports.
[39] S. Walker,et al. Autophagosome biogenesis machinery. , 2019, Journal of molecular biology.
[40] A. Ashkenazi,et al. The Nucleolus as a Proteostasis Regulator. , 2019, Trends in cell biology.
[41] U. Hampel,et al. Ophthalmological Findings in Mucopolysaccharidoses , 2019, Journal of clinical medicine.
[42] P. Libby,et al. Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis , 2019, iScience.
[43] T. Leonard,et al. Lipid-dependent Akt-ivity: where, when, and how , 2019, Biochemical Society transactions.
[44] Astrid S. Pfister. Emerging Role of the Nucleolar Stress Response in Autophagy , 2019, Front. Cell. Neurosci..
[45] S. Chintala,et al. Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation , 2019, Investigative ophthalmology & visual science.
[46] D. Klionsky,et al. Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism. , 2019, Cell metabolism.
[47] B. Turk,et al. Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment , 2019, Cells.
[48] D. Green,et al. LC3-associated phagocytosis at a glance , 2019, Journal of Cell Science.
[49] W. Stamer,et al. A model of the oscillatory mechanical forces in the conventional outflow pathway , 2019, Journal of the Royal Society Interface.
[50] M. van Eijk,et al. Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages , 2018, International journal of molecular sciences.
[51] Sharad Kumar,et al. Autophagy-dependent cell death , 2018, Cell Death & Differentiation.
[52] A. Crandall,et al. TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells , 2018, The Journal of general physiology.
[53] J. Debnath,et al. Autophagy and the cell biology of age-related disease , 2018, Nature Cell Biology.
[54] Guido Kroemer,et al. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? , 2018, Autophagy.
[55] S. Park,et al. Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence , 2018, Ageing Research Reviews.
[56] P. Liton,et al. Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model , 2018, Cell Death Discovery.
[57] Y. Sakai,et al. Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries , 2018, BioEssays : news and reviews in molecular, cellular and developmental biology.
[58] I. Dikic,et al. Mechanism and medical implications of mammalian autophagy , 2018, Nature reviews. Molecular cell biology.
[59] A. Cuervo,et al. The coming of age of chaperone-mediated autophagy , 2018, Nature Reviews Molecular Cell Biology.
[60] Gregory A. Wyant,et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy , 2018, Science.
[61] N. Mizushima. A brief history of autophagy from cell biology to physiology and disease , 2018, Nature Cell Biology.
[62] A. Clark,et al. BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork , 2018, Investigative ophthalmology & visual science.
[63] Y. Maejima,et al. The Role of Autophagy in the Heart. , 2018, Annual review of physiology.
[64] A. Thorburn,et al. Targeting autophagy in cancer , 2017, Nature Reviews Cancer.
[65] I. Dikič. Proteasomal and Autophagic Degradation Systems. , 2017, Annual review of biochemistry.
[66] J. Hurley,et al. Mechanisms of Autophagy Initiation. , 2017, Annual review of biochemistry.
[67] M. Sardiello,et al. AKT modulates the autophagy-lysosome pathway via TFEB , 2017, Cell cycle.
[68] P. Liton,et al. Autophagy and mechanotransduction in outflow pathway cells , 2017, Experimental eye research.
[69] T. Yoshimori,et al. New insights into autophagosome–lysosome fusion , 2017, Journal of Cell Science.
[70] M. Johnstone,et al. Aqueous outflow - A continuum from trabecular meshwork to episcleral veins , 2017, Progress in Retinal and Eye Research.
[71] R. Nixon,et al. Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease , 2016, Ageing Research Reviews.
[72] V. Gorgoulis,et al. DNA Damage Response and Autophagy: A Meaningful Partnership , 2016, Front. Genet..
[73] P. Boya,et al. Autophagy in the eye: Development, degeneration, and aging , 2016, Progress in Retinal and Eye Research.
[74] C. Givens,et al. Endothelial Mechanosignaling: Does One Sensor Fit All? , 2016, Antioxidants & redox signaling.
[75] L. Pedersen,et al. Endocytic Control of Cellular Signaling at the Primary Cilium. , 2016, Trends in biochemical sciences.
[76] G. Prestwich,et al. TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye , 2016, Scientific Reports.
[77] J. Vissers,et al. Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models , 2016, FEBS open bio.
[78] P. Codogno,et al. Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow , 2016, Nature Cell Biology.
[79] P. Liton. The autophagic lysosomal system in outflow pathway physiology and pathophysiology. , 2016, Experimental eye research.
[80] B. Yue,et al. Optineurin: The autophagy connection. , 2016, Experimental eye research.
[81] M. van Eijk,et al. Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease , 2016, PloS one.
[82] A. Clark,et al. Animal models of glucocorticoid-induced glaucoma. , 2015, Experimental eye research.
[83] Harun-Or Rashid,et al. ER stress: Autophagy induction, inhibition and selection , 2015, Autophagy.
[84] I. Pang,et al. Strain and Age Effects on Aqueous Humor Dynamics in the Mouse. , 2015, Investigative ophthalmology & visual science.
[85] J. Debnath,et al. Autophagy at the crossroads of catabolism and anabolism , 2015, Nature Reviews Molecular Cell Biology.
[86] J. Vranka,et al. Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma. , 2015, Experimental eye research.
[87] P. Liton,et al. Autophagic dysregulation in glaucomatous trabecular meshwork cells. , 2015, Biochimica et biophysica acta.
[88] Jin Tan,et al. ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms , 2015, Cellular and Molecular Neurobiology.
[89] C. R. Ethier,et al. Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction , 2015, Progress in Retinal and Eye Research.
[90] Dylan T Burnette,et al. Intracellular and extracellular forces drive primary cilia movement , 2015, Proceedings of the National Academy of Sciences.
[91] C. R. Ethier,et al. Shear stress-triggered nitric oxide release from Schlemm's canal cells. , 2014, Investigative ophthalmology & visual science.
[92] J. Joyce,et al. Pericellular proteolysis in cancer , 2014, Genes & development.
[93] F. Cecconi,et al. Oxidative stress and autophagy: the clash between damage and metabolic needs , 2014, Cell Death and Differentiation.
[94] Yong-feng Yang,et al. Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells. , 2014, Investigative ophthalmology & visual science.
[95] A. Izzotti,et al. Oxidative Damage and Autophagy in the Human Trabecular Meshwork as Related with Ageing , 2014, PloS one.
[96] T. Graham,et al. Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability. , 2014, Canadian journal of physiology and pharmacology.
[97] Myung-Shik Lee,et al. Autophagy—a key player in cellular and body metabolism , 2014, Nature Reviews Endocrinology.
[98] P. Liton,et al. MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. , 2014, Biochimica et biophysica acta.
[99] A. Cuervo,et al. Autophagy and human disease: emerging themes. , 2014, Current opinion in genetics & development.
[100] Neha Aggarwal,et al. Cathepsin B: Multiple roles in cancer , 2014, Proteomics. Clinical applications.
[101] Zhisheng Jiang,et al. Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System , 2014, Annals of Biomedical Engineering.
[102] Val C Sheffield,et al. Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. , 2014, The Journal of clinical investigation.
[103] T. Corson,et al. Primary cilia signaling mediates intraocular pressure sensation , 2014, Proceedings of the National Academy of Sciences.
[104] S. Marchand-Adam,et al. Regulation of TGF-β1-driven Differentiation of Human Lung Fibroblasts , 2014, The Journal of Biological Chemistry.
[105] Y. Qiu,et al. Cellular Processing of Myocilin , 2014, PloS one.
[106] X (inbo) Li,et al. Intraocular pressure homeostasis: maintaining balance in a high-pressure environment. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
[107] P. Liton,et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
[108] I. C. Lloyd,et al. Anterior segment OCT imaging in mucopolysaccharidoses type I, II, and VI , 2014, Eye.
[109] A. Cuervo,et al. Chaperone-mediated autophagy: roles in disease and aging , 2013, Cell Research.
[110] P. Codogno,et al. Functional interaction between autophagy and ciliogenesis , 2013, Nature.
[111] S. Sarkar,et al. Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. , 2013, Biochemical Society transactions.
[112] Shizuo Akira,et al. Autophagy in infection, inflammation and immunity , 2013, Nature Reviews Immunology.
[113] R. Nixon,et al. The role of autophagy in neurodegenerative disease , 2013, Nature Medicine.
[114] Joshua T. Morgan,et al. Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells. , 2013, Experimental eye research.
[115] L. Larsen,et al. TGF-Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium , 2013 .
[116] J. Höhfeld,et al. Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells , 2013, Communicative & integrative biology.
[117] D. Klionsky,et al. The Mechanism and Physiological Function of Macroautophagy , 2013, Journal of Innate Immunity.
[118] P. Liton,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells , 2013, Autophagy.
[119] P. Rabinovitch,et al. mTOR is a key modulator of ageing and age-related disease , 2013, Nature.
[120] Christopher J Murphy,et al. Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ. , 2013, Investigative ophthalmology & visual science.
[121] Xuejun Jiang,et al. The ULK1 complex , 2013, Autophagy.
[122] B. Blagg,et al. Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism* , 2012, The Journal of Biological Chemistry.
[123] J. King. Mechanical stress meets autophagy: potential implications for physiology and pathology. , 2012, Trends in molecular medicine.
[124] Yong-feng Yang,et al. Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility. , 2012, Investigative ophthalmology & visual science.
[125] D. Epstein,et al. Up-Regulated Expression of Extracellular Matrix Remodeling Genes in Phagocytically Challenged Trabecular Meshwork Cells , 2012, PloS one.
[126] E. White. Role of autophagy in cancer , 2012 .
[127] M. Nebbioso,et al. Trabecular Meshwork in Normal and Pathological Eyes , 2012, Ultrastructural pathology.
[128] J. Bao,et al. Microautophagy: lesser-known self-eating , 2012, Cellular and Molecular Life Sciences.
[129] Craig E. Higgins,et al. Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades , 2012, Biochemistry research international.
[130] Matthew E. Downs,et al. The mechanics of the primary cilium: an intricate structure with complex function. , 2012, Journal of biomechanics.
[131] P. Codogno,et al. Canonical and non-canonical autophagy: variations on a common theme of self-eating? , 2011, Nature Reviews Molecular Cell Biology.
[132] R. Insall,et al. The induction of autophagy by mechanical stress , 2011, Autophagy.
[133] Z. Werb,et al. Extracellular matrix degradation and remodeling in development and disease. , 2011, Cold Spring Harbor perspectives in biology.
[134] V. Deretic,et al. Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β , 2011, The EMBO journal.
[135] D. Corella,et al. Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population , 2011, Molecular vision.
[136] Michael G. Anderson,et al. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. , 2011, The Journal of clinical investigation.
[137] J. Vranka,et al. Segmental versican expression in the trabecular meshwork and involvement in outflow facility. , 2011, Investigative ophthalmology & visual science.
[138] M. Czaja. Functions of autophagy in hepatic and pancreatic physiology and disease. , 2011, Gastroenterology.
[139] G. Kroemer,et al. Autophagy for tissue homeostasis and neuroprotection. , 2011, Current opinion in cell biology.
[140] D. Epstein,et al. Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. , 2010, Investigative ophthalmology & visual science.
[141] F. Boisvert,et al. The Nucleolus under Stress , 2010, Molecular Cell.
[142] E. Bottinger,et al. BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation , 2010, PloS one.
[143] N. Mizushima,et al. Autophagy in mammalian development and differentiation , 2010, Nature Cell Biology.
[144] R. Xavier,et al. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease , 2010, Proceedings of the National Academy of Sciences.
[145] I. Pang,et al. Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes. , 2010, Investigative ophthalmology & visual science.
[146] C. Kenyon. The genetics of ageing , 2010, Nature.
[147] M. Hoch,et al. Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance , 2010, Current Biology.
[148] G. Bjørkøy,et al. Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies* , 2009, The Journal of Biological Chemistry.
[149] Shuhei Yoshida,et al. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. , 2009, Cancer research.
[150] Sterling C. Johnson,et al. Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys , 2009, Science.
[151] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[152] K. Brix,et al. Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation , 2009, Biological chemistry.
[153] She Chen,et al. ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy* , 2009, Journal of Biological Chemistry.
[154] M. T. Leite,et al. Ascorbic acid concentration is reduced in the secondary aqueous humour of glaucomatous patients , 2009, Clinical & experimental ophthalmology.
[155] D. WuDunn. Mechanobiology of trabecular meshwork cells. , 2009, Experimental eye research.
[156] Ernst R Tamm,et al. The trabecular meshwork outflow pathways: structural and functional aspects. , 2009, Experimental eye research.
[157] E. Lütjen-Drecoll,et al. Structural changes of the trabecular meshwork in different kinds of glaucoma. , 2009, Experimental eye research.
[158] D. Epstein,et al. Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells , 2009, Molecular vision.
[159] T. Acott,et al. Specialized podosome- or invadopodia-like structures (PILS) for focal trabecular meshwork extracellular matrix turnover. , 2008, Investigative ophthalmology & visual science.
[160] Bonnie F. Sloane,et al. Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. , 2008, Cancer research.
[161] J. Biswas,et al. Ocular manifestation of storage diseases , 2008, Current opinion in ophthalmology.
[162] D. Epstein,et al. Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. , 2008, Investigative ophthalmology & visual science.
[163] P. Liton,et al. Stress Response of the Trabecular Meshwork , 2008, Journal of glaucoma.
[164] D. Klionsky. Autophagy revisited: A conversation with Christian de Duve , 2008, Autophagy.
[165] J. Leza,et al. Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma. , 2008, Investigative ophthalmology & visual science.
[166] M. Pinazo-Durán,et al. Oxidative Stress in Primary Open-angle Glaucoma , 2008, Journal of glaucoma.
[167] T. Acott,et al. Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture. , 2008, Investigative ophthalmology & visual science.
[168] G. Taraboletti,et al. Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles. , 2008, Neoplasia.
[169] J. Ge,et al. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. , 2008, Investigative ophthalmology & visual science.
[170] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[171] K. Brix,et al. Cysteine cathepsins: cellular roadmap to different functions. , 2008, Biochimie.
[172] Guido Kroemer,et al. Autophagy in the Pathogenesis of Disease , 2008, Cell.
[173] D. Epstein,et al. Sustained stress response after oxidative stress in trabecular meshwork cells , 2007, Molecular vision.
[174] U. Hopfer,et al. Force-response considerations in ciliary mechanosensation. , 2007, Biophysical journal.
[175] N. Agarwal,et al. Oxidative Stress in Glaucoma: A Burden of Evidence , 2007, Journal of glaucoma.
[176] J. Roth,et al. Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. , 2007, Investigative Ophthalmology and Visual Science.
[177] A. Izzotti,et al. Glaucomatous outflow pathway and oxidative stress. , 2007, Experimental eye research.
[178] U. Brunk,et al. Autophagy, organelles and ageing , 2007, The Journal of pathology.
[179] D. Epstein,et al. Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. , 2006, Molecular vision.
[180] D. DiMaio,et al. Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase , 2006 .
[181] P. Kaufman,et al. Changes in aqueous humor dynamics with age and glaucoma , 2005, Progress in Retinal and Eye Research.
[182] D. Epstein,et al. Cellular senescence in the glaucomatous outflow pathway , 2005, Experimental Gerontology.
[183] A. Izzotti,et al. Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. , 2005, Archives of ophthalmology.
[184] Bonnie F. Sloane,et al. Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. , 2005, Seminars in cancer biology.
[185] Bonnie F. Sloane,et al. Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells , 2005, Journal of Cell Science.
[186] M. Johnstone. The Aqueous Outflow System as a Mechanical Pump: Evidence from Examination of Tissue and Aqueous Movement in Human and Non-Human Primates , 2004, Journal of glaucoma.
[187] C. R. Ethier,et al. Biomechanics of Schlemm's canal endothelial cells: influence on F-actin architecture. , 2004, Biophysical journal.
[188] D. Vollrath,et al. Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma , 2004 .
[189] W. Hur,et al. Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells. , 2003, Biochemical and biophysical research communications.
[190] T. Acott,et al. Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch. , 2003, Investigative ophthalmology & visual science.
[191] M. Kruszewski,et al. Labile iron pool: the main determinant of cellular response to oxidative stress. , 2003, Mutation research.
[192] D. Hall,et al. Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans , 2003, Science.
[193] J. Magaud,et al. Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging , 2003, Experimental Gerontology.
[194] P. Kaufman,et al. Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys. , 2003, Investigative ophthalmology & visual science.
[195] Jing Zhou,et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.
[196] N. Mizushima,et al. Autophagosome formation in mammalian cells. , 2002, Cell structure and function.
[197] U. Schlötzer-Schrehardt,et al. Ascorbic acid concentration is reduced in the aqueous humor of patients with exfoliation syndrome. , 2002, American journal of ophthalmology.
[198] Young H. Kwon,et al. Variations in the myocilin gene in patients with open-angle glaucoma. , 2002, Archives of ophthalmology.
[199] J. Joseph,et al. Stimulatory effect of vitamin C on autophagy in glial cells , 2002, Journal of neurochemistry.
[200] Randy L. Johnson,et al. Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function , 2001, Molecular and Cellular Biology.
[201] H. Lijnen. Elements of the Fibrinolytic System , 2001, Annals of the New York Academy of Sciences.
[202] T. Acott,et al. Effects of mechanical stretching on trabecular matrix metalloproteinases. , 2001, Investigative ophthalmology & visual science.
[203] T. Borrás,et al. Inefficient processing of an olfactomedin-deficient myocilin mutant: potential physiological relevance to glaucoma. , 2001, Biochemical and biophysical research communications.
[204] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[205] D. Kurz,et al. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. , 2000, Journal of cell science.
[206] W. Alward. The genetics of open-angle glaucoma: The story of GLC1A and myocilin , 2000, Eye.
[207] R. Wordinger,et al. Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma , 1999, Progress in Retinal and Eye Research.
[208] Michael D. George,et al. A protein conjugation system essential for autophagy , 1998, Nature.
[209] D. Epstein,et al. Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. , 1998, Investigative ophthalmology & visual science.
[210] A. Spector,et al. The aqueous humor is capable of generating and degrading H2O2. , 1998, Investigative ophthalmology & visual science.
[211] T H Roderick,et al. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. , 1998, Investigative ophthalmology & visual science.
[212] P. Palmberg,et al. Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma. , 1996, Investigative ophthalmology & visual science.
[213] D. Epstein,et al. Effect of age on superoxide dismutase activity of human trabecular meshwork. , 1996, Investigative ophthalmology & visual science.
[214] P. Palmberg,et al. Glycosaminoglycans of the human trabecular meshwork in primary open-angle glaucoma. , 1996, Investigative ophthalmology & visual science.
[215] D. Klionsky,et al. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway , 1995, The Journal of cell biology.
[216] R. Tripathi,et al. Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2 , 1994 .
[217] M. Schlumpberger,et al. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae , 1994, FEBS letters.
[218] Y. Ohsumi,et al. Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae , 1993, FEBS letters.
[219] S. Tsuboi,et al. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction , 1992, The Journal of cell biology.
[220] D. Klionsky,et al. Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway , 1992, The Journal of cell biology.
[221] A. Sommer,et al. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. , 1991, JAMA.
[222] C. Buller,et al. Human trabecular meshwork phagocytosis. Observations in an organ culture system. , 1990, Investigative ophthalmology & visual science.
[223] G. Sarkis,et al. Decline in protease activities with age in the nematode caenorhabditis elegans , 1988, Mechanisms of Ageing and Development.
[224] M. Sherwood,et al. Phagocytosis by trabecular meshwork cells: sequence of events in cats and monkeys. , 1988, Experimental eye research.
[225] K. Bridges,et al. Ascorbic acid inhibits lysosomal autophagy of ferritin. , 1987, The Journal of biological chemistry.
[226] E. V. Van Buskirk,et al. Trabecular meshwork glycosaminoglycans in human and cynomolgus monkey eye. , 1985, Investigative ophthalmology & visual science.
[227] J. Polansky,et al. Age-related changes in trabecular meshwork cellularity. , 1981, Investigative ophthalmology & visual science.
[228] I. Grierson,et al. Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm's canal. , 1975, American journal of ophthalmology.
[229] I. Grierson,et al. The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (1) Pressure effects within the near-physiological range (8-30 mmHg). , 1975, Experimental eye research.
[230] M. Johnstone,et al. Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes. , 1973, American journal of ophthalmology.
[231] D. Coleman,et al. Direct-recorded intraocular pressure variations in a human subject. , 1969, Archives of ophthalmology.
[232] E. Linnér,et al. THE PRESSURE LOWERING EFFECT OF ASCORBIC ACID IN OCULAR HYPERTENSION , 1969, Acta ophthalmologica.
[233] C. Behl,et al. Ubiquitin-Dependent And Independent Signals In Selective Autophagy. , 2016, Trends in cell biology.
[234] E. Tamm,et al. Intraocular Pressure and the Mechanisms Involved in Resistance of the Aqueous Humor Flow in the Trabecular Meshwork Outflow Pathways. , 2015, Progress in molecular biology and translational science.
[235] Haoxing Xu,et al. Lysosomal physiology. , 2015, Annual review of physiology.
[236] S. Ryter,et al. Autophagy in pulmonary diseases. , 2012, Annual review of physiology.
[237] M. Komatsu,et al. Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models. , 2011, Experimental animals.
[238] N. Mizushima. Physiological functions of autophagy. , 2009, Current topics in microbiology and immunology.
[239] U. Hopfer,et al. Mechanical stimulation of primary cilia. , 2008, Frontiers in bioscience : a journal and virtual library.
[240] Bonnie F. Sloane,et al. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH , 2006, Biological chemistry.
[241] D. Epstein,et al. Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. , 2002, Investigative ophthalmology & visual science.
[242] A. Amon,et al. Erratum: The nucleolus: The magician's hat for cell cycle tricks (Current Opinion in Cell Biology (2000) 12 (372-377)) , 2000 .
[243] A. Cuervo,et al. How do intracellular proteolytic systems change with age? , 1998, Frontiers in bioscience : a journal and virtual library.
[244] T. Li,et al. Age-related changes in trabecular cells in vitro. , 1997, Experimental eye research.
[245] N. Delamere. Ascorbic acid and the eye. , 1996, Sub-cellular biochemistry.