Associations of TNF-α and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E)

[1]  Chih‐Hsueh Lin,et al.  Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E) , 2014, Experimental Gerontology.

[2]  C-C Lin,et al.  Vitamin D receptor variability and physical activity are jointly associated with low handgrip strength and osteoporosis in community-dwelling elderly people in Taiwan: the Taichung Community Health Study for Elders (TCHS-E) , 2014, Osteoporosis International.

[3]  M. Acalovschi,et al.  Hormonal and cytokine implications in the pathophysiology of osteoporosis occurring in chronic liver diseases. , 2012, Maedica.

[4]  E. Hoffman,et al.  Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training. , 2012, Gene.

[5]  Yoko Watanabe,et al.  The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women. , 2012, Gene.

[6]  Chia-Ing Li,et al.  Reduced Health-Related Quality of Life in Elders with Frailty: A Cross-Sectional Study of Community-Dwelling Elders in Taiwan , 2011, PloS one.

[7]  Simin Liu,et al.  Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational Study. , 2011, Clinical chemistry.

[8]  Christoph Lange,et al.  The Fundamentals of Modern Statistical Genetics , 2010 .

[9]  J. Caetano-Lopes,et al.  Osteoimmunology--the hidden immune regulation of bone. , 2009, Autoimmunity reviews.

[10]  J. Caetano-Lopes,et al.  Assessment of laboratory measurements and −308 TNFα gene promoter polymorphisms in normal bone mineral density , 2008, Clinical Rheumatology.

[11]  R. Rizzoli,et al.  Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptor. , 2007, The Journal of clinical endocrinology and metabolism.

[12]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[13]  C. Christiansen,et al.  Leptin Receptor Genotype at Gln223Arg is Associated With Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  C. Mantzoros,et al.  Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. , 2007, Atherosclerosis.

[15]  W. Pan,et al.  A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. , 2006, Journal of biomedical science.

[16]  Y. Chagnon,et al.  Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study , 2006, International Journal of Obesity.

[17]  B. Riggs,et al.  The role of the immune system in the pathophysiology of osteoporosis , 2005, Immunological reviews.

[18]  S. Cummings,et al.  Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women. , 2005, The Journal of clinical endocrinology and metabolism.

[19]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[20]  T. Thomas The complex effects of leptin on bone metabolism through multiple pathways. , 2004, Current opinion in pharmacology.

[21]  N. Sakuragi,et al.  Bone Mineral Density of the Lumbar Spine is Associated with TNF Gene Polymorphisms in Early Postmenopausal Japanese Women , 2004, Calcified Tissue International.

[22]  J. Souberbielle,et al.  Bone mineral density directly correlates with elevated serum leptin in haemodialysis patients. , 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[23]  S. Ralston Genetic determinants of susceptibility to osteoporosis. , 2003, Current opinion in pharmacology.

[24]  H. Shin,et al.  Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women , 2003, Journal of Human Genetics.

[25]  M. Schroll,et al.  Predicting death from tumour necrosis factor‐alpha and interleukin‐6 in 80‐year‐old people , 2003, Clinical and experimental immunology.

[26]  S. Humphries,et al.  Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. , 2003, The Journal of clinical endocrinology and metabolism.

[27]  Ki-Up Lee,et al.  Estrogen receptor a gene polymorphisms (Pvu II and Xba I) influence association between leptin receptor gene polymorphism (Gln223Arg) and bone mineral density in young men , 2002 .

[28]  P. Delmas,et al.  Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study. , 2002, Bone.

[29]  Sundeep Khosla,et al.  Sex steroids and the construction and conservation of the adult skeleton. , 2002, Endocrine reviews.

[30]  S. Inoue,et al.  Association of a single nucleotide variant in the human tumour necrosis factor alpha promoter region with decreased bone mineral density , 2002, Annals of human biology.

[31]  Y. Chagnon,et al.  Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women , 2001, International Journal of Obesity.

[32]  S. Inoue,et al.  A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density , 2001, Journal of Human Genetics.

[33]  R. Curi,et al.  The response of skeletal muscle to leptin. , 2001, Frontiers in bioscience : a journal and virtual library.

[34]  A. Hajeer,et al.  TNF‐α gene polymorphism: Clinical and biological implications , 2000 .

[35]  F. Green,et al.  Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation* , 2000, The Journal of Biological Chemistry.

[36]  S. Manolagas,et al.  Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. , 2000, Endocrine reviews.

[37]  A. Hajeer,et al.  TNF-alpha gene polymorphism: clinical and biological implications. , 2000, Microscopy research and technique.

[38]  T. Nakajima,et al.  Linkage of human tumor necrosis factor-alpha to human osteoporosis by sib-pair analysis , 2000, Genes and Immunity.

[39]  L. Abraham,et al.  Impact of the ‐308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease , 1999, Journal of leukocyte biology.

[40]  S. Manolagas The Role of IL‐6 Type Cytokines and Their Receptors in Bonea a , 1998 .

[41]  M. Jordana,et al.  IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. , 1998, The Journal of clinical investigation.

[42]  S. Manolagas The role of IL-6 type cytokines and their receptors in bone. , 1998, Annals of the New York Academy of Sciences.

[43]  Y. Yoshimasa,et al.  Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity , 1997, Diabetologia.

[44]  E. Ravussin,et al.  Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. , 1997, Human molecular genetics.

[45]  H. Mcdevitt,et al.  Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Reginster,et al.  Increase in cytokine production (IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis. , 1997, Maturitas.

[47]  Roberto Pacifici,et al.  Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[48]  T. Hyde,et al.  The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. , 1996, Diabetes.

[49]  Su‐Li Cheng,et al.  Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-alpha is not regulated by ovarian steroids. , 1995, Endocrinology.

[50]  S. Manolagas,et al.  Role of cytokines in bone resorption. , 1995, Bone.

[51]  R. Jilka,et al.  Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. , 1995, The New England journal of medicine.

[52]  R. Jilka,et al.  New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. , 1995, International journal of immunopharmacology.

[53]  M. Kluger Role of Cytokines in the Acute Phase Response , 1994 .

[54]  D. Chaplin,et al.  Highly informative typing of the human TNF locus using six adjacent polymorphic markers. , 1993, Genomics.

[55]  J. Shine,et al.  Cloning and expression of full-length cDNA encoding human vitamin D receptor. , 1988, Proceedings of the National Academy of Sciences of the United States of America.