MRI and localized proton spectroscopy in human leg muscle at 7 tesla using longitudinal traveling waves

Using a small resonant loop to produce a longitudinal traveling wave on a human 7‐T system allows MR to be performed over the entire volume of the human leg. We have used this capability to perform localized proton MR spectroscopy of the lipid composition of muscle in volunteers with a coil placed ∼30 cm away from the region of interest. Spectra with a reasonable signal‐to‐noise ratio can be acquired in a clinically relevant data acquisition time of less than 5 min using the loop in transmit/receive mode, maintaining the full flexibility to acquire spectra from any part of the calf and/or thigh. If a local receive coil is used in combination with the remote transmit coil, then the signal‐to‐noise improves significantly, as expected. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.

[1]  Vicente Gilsanz,et al.  Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: preliminary study. , 2008, AJR. American journal of roentgenology.

[2]  Sharmila Majumdar,et al.  In vivo ultra‐high‐field magnetic resonance imaging of trabecular bone microarchitecture at 7 T , 2008, Journal of magnetic resonance imaging : JMRI.

[3]  G. Liu,et al.  Duchenne muscular dystrophy: MR grading system with functional correlation. , 1993, Radiology.

[4]  Klaas P. Pruessmann,et al.  Travelling-wave nuclear magnetic resonance , 2009, Nature.

[5]  Sharmila Majumdar,et al.  Rapid in vivo musculoskeletal MR with parallel imaging at 7T , 2008, Magnetic resonance in medicine.

[6]  Sharmila Majumdar,et al.  GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T. , 2009, Magnetic resonance imaging.

[7]  S. F. Mahmoud,et al.  Electromagnetic Waveguides: Theory and applications , 1991 .

[8]  Ravinder R Regatte,et al.  In vivo 7.0-tesla magnetic resonance imaging of the wrist and hand: technical aspects and applications. , 2009, Seminars in musculoskeletal radiology.

[9]  D. Hilton.  Muscle Biopsy – A Practical Approach (3rd edition) , 2007 .

[10]  Jeff H. Duyn,et al.  High-field MRI of brain cortical substructure based on signal phase , 2007, Proceedings of the National Academy of Sciences.

[11]  G J Metzger,et al.  Initial results of cardiac imaging at 7 tesla , 2009, Magnetic resonance in medicine.

[12]  A. Sherry,et al.  Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla* , 2008, Journal of Lipid Research.

[13]  Essa Yacoub,et al.  Robust detection of ocular dominance columns in humans using Hahn Spin Echo BOLD functional MRI at 7 Tesla , 2007, NeuroImage.

[14]  Marinos C. Dalakas,et al.  Muscle biopsy — a practical approach , 1986, The Ulster Medical Journal.

[15]  Wietske van der Zwaag,et al.  In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T , 2009, Magnetic Resonance Materials in Physics, Biology and Medicine.

[16]  A. Webb,et al.  Design of a ceramic dielectric resonator for NMR microimaging at 14.1 tesla , 2008 .

[17]  Peter Andersen,et al.  Whole‐body imaging at 7T: Preliminary results , 2009, Magnetic resonance in medicine.

[18]  S. Nelson,et al.  Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron , 2008, Annals of neurology.

[19]  D. Woessner,et al.  Orientation of lipid strands in the extracellular compartment of muscle: Effect on quantitation of intramyocellular lipids , 2009, Magnetic resonance in medicine.

[20]  Zang-Hee Cho,et al.  Imaging and analysis of lenticulostriate arteries using 7.0‐Tesla magnetic resonance angiography , 2009, Magnetic resonance in medicine.

[21]  K Ugurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at 7 T , 2001, Magnetic resonance in medicine.

[22]  G. Metzger,et al.  Local B1+ shimming for prostate imaging with transceiver arrays at 7T based on subject‐dependent transmit phase measurements , 2008, Magnetic resonance in medicine.

[23]  K. Uğurbil,et al.  Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T. , 2006, Magnetic resonance imaging.

[24]  Steen Moeller,et al.  A geometrically adjustable 16‐channel transmit/receive transmission line array for improved RF efficiency and parallel imaging performance at 7 Tesla , 2008, Magnetic resonance in medicine.

[25]  Pratik Mukherjee,et al.  High‐Resolution Phased‐Array MRI of the Human Brain at 7 Tesla: Initial Experience in Multiple Sclerosis Patients , 2010, Journal of neuroimaging : official journal of the American Society of Neuroimaging.