The National Heart, Lung, and Blood Institute bench to bassinet Program: a new paradigm for translational research.

Congenital heart disease (CHD) is the most common birth defect and is a significant source of morbidity and mortality in children. Despite considerable recent progress in the clinical arena, we have a lot yet to learn about the causes of CHD and the genetic modifiers of clinical outcome. It is our

[1]  E. Olson,et al.  Gene Regulatory Networks in the Evolution and Development of the Heart , 2006, Science.

[2]  D. Srivastava,et al.  Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. , 2007, Circulation.

[3]  M. Daly,et al.  Genetic Mapping in Human Disease , 2008, Science.

[4]  J. Saul,et al.  The Pediatric Heart Network: A Primer for the Conduct of Multicenter Studies in Children with Congenital and Acquired Heart Disease , 2006, Pediatric Cardiology.

[5]  D. Benson.  Advances in cardiovascular genetics and embryology: role of transcription factors in congenital heart disease , 2000, Current opinion in pediatrics.

[6]  F. Collins,et al.  The HapMap and genome-wide association studies in diagnosis and therapy. , 2009, Annual review of medicine.

[7]  B. McCrindle,et al.  Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. , 2009, American heart journal.

[8]  B. Bruneau.  The developmental genetics of congenital heart disease , 2008, Nature.

[9]  S. Colan,et al.  Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome. , 2007, American heart journal.

[10]  S. Colan,et al.  Design and rationale of a randomized trial comparing the Blalock-Taussig and right ventricle-pulmonary artery shunts in the Norwood procedure. , 2008, The Journal of thoracic and cardiovascular surgery.

[11]  Benson Dw.  Advances in cardiovascular genetics and embryology: role of transcription factors in congenital heart disease. , 2000 .

[12]  A. Michelson,et al.  Toward a systems-level understanding of developmental regulatory networks. , 2008, Current opinion in genetics & development.

[13]  Bin Liu,et al.  Functional genetic analysis of mouse chromosome 11 , 2003, Nature.

[14]  H. Boyd,et al.  Recurrence of Congenital Heart Defects in Families , 2009, Circulation.