Smart biopolymers and their applications

Abstract Polymers have a sacred space in science. It is a well-known fact that due to some unique and specific properties polymers are used in a wide range of applications. Among them smart biopolymers have gained attention of researchers worldwide due to their unique properties such as biodegradability, biocompatibility, inexpensiveness, and renewability. Furthermore, these smart biopolymers show a characteristic property of responsiveness to stimuli such as temperature, pH, magnetic and electrical field, chemical, mechanical stress, and light. Consequently, succeeding chapter will briefly shed light about such smart biopolymers, their classification, and applications. Special attention is laid on the potential applicability of such smart biopolymers in the field of drug delivery, tissue engineering scaffolds, bioseparation, biotechnology, other medicinal fields, etc. The versatility and unique potential of these smart polymers make them one of the important parts of science, specifically medicine and drug delivery.

[1]  Aurelio Salerno,et al.  Bio-based polymers, supercritical fluids and tissue engineering , 2015 .

[2]  Augustine Amalraj,et al.  Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review , 2016 .

[3]  D. Schmaljohann.  Thermo- and pH-responsive polymers in drug delivery. , 2006, Advanced drug delivery reviews.

[4]  Teruo Okano,et al.  Pulsatile drug release control using hydrogels. , 2002, Advanced drug delivery reviews.

[5]  Jin-Oh You,et al.  Bioresponsive matrices in drug delivery , 2010, Journal of biological engineering.

[6]  K. Dušek,et al.  Structure and elasticity of non-crystalline polymer networks , 1969 .

[7]  N. Yu,et al.  Macromolecule hydration and the effect of solutes on the cloud point of aqueous solutions of polyvinyl methyl ether: a possible model for protein denaturation and temperature control in homeothermic animals. , 1971, Journal of colloid and interface science.

[8]  V. Pillay,et al.  Stimuli-responsive polymers and their applications in drug delivery , 2009, Biomedical materials.

[9]  B. Mele,et al.  Influence of Poly(ethylene oxide) Grafts on Kinetics of LCST Behavior in Aqueous Poly(N-vinylcaprolactam) Solutions and Networks Studied by Modulated Temperature DSC , 2004 .

[10]  Feng Tian,et al.  Facile synthesis of triple‐stimuli (photo/pH/thermo) responsive copolymers of 2‐diazo‐1,2‐naphthoquinone‐mediated poly(N‐isopropylacrylamide‐co‐N‐hydroxymethylacrylamide) , 2009 .

[11]  Pei Li,et al.  Novel synthesis and properties of smart core-shell microgels , 2005 .

[12]  A. Gallardo,et al.  Smart Polymers and Their Applications as Biomaterials , 2007 .

[13]  Paul Kiekens,et al.  Biopolymers: overview of several properties and consequences on their applications. , 2002 .

[14]  A. Khokhlov,et al.  Conformational Changes of Poly(vinylcaprolactam) Macromolecules and Their Complexes with Ionic Surfactants in Aqueous Solution , 1998 .

[15]  Toyoichi Tanaka,et al.  Phase transition in polymer gels induced by visible light , 1990, Nature.

[16]  J. P. Huang,et al.  Response of ferrogels subjected to an ac magnetic field. , 2006, The journal of physical chemistry. B.

[17]  T. Okano,et al.  Novel thermally reversible hydrogel as detachable cell culture substrate. , 1998, Journal of biomedical materials research.

[18]  Peter Babinec,et al.  SUPERPARAMAGNETIC GEL AS A NOVEL MATERIAL FOR ELECTROMAGNETICALLY INDUCED HYPERTHERMIA , 2001 .

[19]  Victor Malgras,et al.  Multi-Stimuli-Responsive Polymeric Materials. , 2015, Chemistry.

[20]  D. Gravel,et al.  Thermosensitivity of Aqueous Solutions of Poly(N,N-diethylacrylamide) , 1999 .

[21]  Jay D Keasling,et al.  BglBricks: A flexible standard for biological part assembly , 2010, Journal of biological engineering.

[22]  Giles Richardson,et al.  Mathematical modelling of magnetically targeted drug delivery , 2005 .

[23]  M. Jasionowski,et al.  Injectable gels for tissue engineering , 2001, The Anatomical record.

[24]  K. Widder,et al.  Magnetic guidance of drug‐carrying microspheres , 1978 .

[25]  J. Leroux,et al.  In situ-forming hydrogels--review of temperature-sensitive systems. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  T. Shiga.  Deformation and Viscoelastic Behavior of Polymer Gels in Electric Fields , 1997 .

[27]  C. Alexander,et al.  Thermoresponsive Surface-Grafted Poly(N−isopropylacrylamide) Copolymers: Effect of Phase Transitions on Protein and Bacterial Attachment , 2003 .

[28]  G. López,et al.  Lower critical solubility temperature materials as biofouling release agents , 1998, Journal of Industrial Microbiology and Biotechnology.

[29]  H. G. Schild.  Poly(N-isopropylacrylamide): experiment, theory and application , 1992 .

[30]  A S Hoffman,et al.  Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[31]  A. Hoffman,et al.  Smart polymeric carriers for enhanced intracellular delivery of therapeutic macromolecules , 2005, Expert opinion on biological therapy.

[32]  T. Shinbo,et al.  Characteristic Phase Transition of Aqueous Solution of Poly(N-isopropylacrylamide) Functionalized with Spirobenzopyran , 2004 .

[33]  K. O’Connor,et al.  Current progress on bio-based polymers and their future trends , 2013, Progress in Biomaterials.

[34]  T. Okano,et al.  Cell Attachment–Detachment Control on Temperature-Responsive Thin Surfaces for Novel Tissue Engineering , 2010, Annals of Biomedical Engineering.

[35]  S. Murdan.  Electro-responsive drug delivery from hydrogels. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[36]  T. Park,et al.  Swelling Induced Detachment of Chondrocytes Using RGD‐Modified Poly(N‐isopropylacrylamide) Hydrogel Beads , 2002, Biotechnology progress.

[37]  M. Ward,et al.  Thermoresponsive terpolymers based on methacrylate monomers: Effect of architecture and composition , 2010 .

[38]  M. Plötner,et al.  Photopatterning of thermally sensitive hydrogels useful for microactuators , 1999 .

[39]  I. Verma,et al.  Gene therapy - promises, problems and prospects , 1997, Nature.

[40]  A Hatefi,et al.  Biodegradable injectable in situ forming drug delivery systems. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[41]  Nikolaos A. Peppas,et al.  Hydrogels and drug delivery , 1997 .

[42]  Ron,et al.  Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. , 1998, Advanced drug delivery reviews.

[43]  Dan W. Urry,et al.  Five axioms for the functional design of peptide‐based polymers as molecular machines and materials: Principle for macromolecular assemblies , 1998 .

[44]  K. Matyjaszewski,et al.  Stimuli-responsive molecular brushes , 2010 .

[45]  Jinlian Hu,et al.  Smart polymer fibers with shape memory effect , 2006 .

[46]  N. Ogata,et al.  Thermosensitivity of optically active hydrogels constructed with N-(L)-(1-hydroxymethyl)propylmethacrylamide. , 2004, Macromolecular bioscience.

[47]  T. Maekawa,et al.  POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING APPLICATION: A REVIEW , 2011 .

[48]  E. Gil,et al.  Stimuli-reponsive polymers and their bioconjugates , 2004 .

[49]  Miklós Zrínyi,et al.  Electric field sensitive neutral polymer gels , 2000 .

[50]  M. Ward,et al.  Thermoresponsive Polymers for Biomedical Applications , 2011 .

[51]  Suna Choi,et al.  Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats , 2004, Pharmaceutical Research.

[52]  Mitsuhiro Shibayama,et al.  Cross-link Density Dependence of Spatial Inhomogeneities and Dynamic Fluctuations of Poly(N-isopropylacrylamide) Gels , 1996 .

[53]  Yanlei Yu,et al.  Dual Responsive Block Copolymer Micelles Functionalized by NIPAM and Azobenzene. , 2010, Macromolecular rapid communications.

[54]  Kinam Park,et al.  Environment-sensitive hydrogels for drug delivery , 2001 .

[55]  T. Okano,et al.  Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces. , 1995, Biomaterials.

[56]  Javier Reguera,et al.  Developing functionality in elastin-like polymers by increasing their molecular complexity: the power of the genetic engineering approach , 2005 .

[57]  Allan S. Hoffman,et al.  “intelligent” polymers in medicine and biotechnology , 1995 .

[58]  Y. Osada,et al.  INTELLIGENT GELS : SOFT AGGREGATIONS OF LONG-CHAIN MOLECULES CAN SHRINK ORSWELL IN RESPONSE TO STIMULI. THEY MAY FORM THE BASIS OF A NEW KIND OF MACH INE , 1993 .

[59]  A. Hoffman,et al.  Smart delivery systems for biomolecular therapeutics , 2005 .

[60]  V. Pillay,et al.  A Review of Multi-Responsive Membranous Systems for Rate-Modulated Drug Delivery , 2010, AAPS PharmSciTech.

[61]  A. D'emanuele,et al.  On-off transport through a thermoresponsive hydrogel composite membrane. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[62]  A. Atala,et al.  Biomaterials for tissue engineering , 2000, World Journal of Urology.

[63]  Y. Gan,et al.  Poly(N-acryloyl-N'-propylpiperazine) : A new stimuli-responsive polymer , 2000 .

[64]  R Langer,et al.  Responsive polymeric delivery systems. , 2001, Advanced drug delivery reviews.

[65]  K. Anoop,et al.  Smart polymers for the controlled delivery of drugs – a concise overview , 2014, Acta pharmaceutica Sinica. B.

[66]  M. Zrínyi,et al.  Direct observation of abrupt shape transition in ferrogels induced by nonuniform magnetic field , 1997 .

[67]  Naoya Ogata,et al.  Temperature-Responsive Interpenetrating Polymer Networks Constructed with Poly(Acrylic Acid) and Poly(N,N-Dimethylacrylamide) , 1994 .

[68]  P. Couvreur,et al.  Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[69]  Rushi Ghizal,et al.  Smart Polymers and Their Applications , 2014 .

[70]  T. Kissel,et al.  In situ forming parenteral drug delivery systems: an overview. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[71]  Yuri D. Zaroslov,et al.  Hydrophobic aggregation in aqueous solutions of hydrophobically modified polyacrylamide in the vicinity of overlap concentration , 2003 .

[72]  Anna Gutowska,et al.  Lessons from nature: stimuli-responsive polymers and their biomedical applications. , 2002, Trends in biotechnology.

[73]  I. S. Zanaveskina,et al.  Poly(acrylamide) gels with embedded magnetite nanoparticles , 2003 .

[74]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[75]  J. Feijen,et al.  Characterization of the Network Structure of Carbodiimide Cross-Linked Gelatin Gels , 1999 .

[76]  Robert J. Davis,et al.  Magnetic assembly and pyrolysis of functional ferromagnetic colloids into one-dimensional carbon nanostructures. , 2007, Journal of the American Chemical Society.

[77]  K. Dušek,et al.  Transition in swollen polymer networks induced by intramolecular condensation , 1968 .

[78]  Masayuki Yamato,et al.  Thermally responsive polymer-grafted surfaces facilitate patterned cell seeding and co-culture. , 2002, Biomaterials.

[79]  A. Mikos,et al.  Recent progress in gene delivery using non-viral transfer complexes. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[80]  Alexander Chan,et al.  Remote and local control of stimuli responsive materials for therapeutic applications. , 2013, Advanced drug delivery reviews.

[81]  T. Okano,et al.  Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[82]  Ipsita Roy,et al.  Smart polymeric materials: emerging biochemical applications. , 2003, Chemistry & biology.

[83]  N. Peppas,et al.  Poly(ethylene glycol)-containing hydrogels in drug delivery. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[84]  Anil Kumar Bajpai,et al.  Responsive polymers in controlled drug delivery , 2008 .