Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.

[1]  K. Flaherty,et al.  Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  Ashley M. Zehnder,et al.  IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors , 2013, Nature Medicine.

[3]  U. Lopes,et al.  The GTPase TcRjl of the human pathogen Trypanosoma cruzi is involved in the cell growth and differentiation. , 2012, Biochemical and biophysical research communications.

[4]  G. Sauter,et al.  Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. , 2012, Cancer research.

[5]  F. Hodi,et al.  Vemurafenib and BRAF Inhibition: A New Class of Treatment for Metastatic Melanoma , 2011, Clinical Cancer Research.

[6]  Krzysztof Goryca,et al.  Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability , 2010, PloS one.

[7]  Kam Y. J. Zhang,et al.  Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma , 2010, Nature.

[8]  Chao Zhang,et al.  RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF , 2010, Nature.

[9]  Thomas Downey,et al.  A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics , 2010, Clinical & Experimental Metastasis.

[10]  Peter A. Jones,et al.  Epigenetics in cancer. , 2010, Carcinogenesis.

[11]  S. Seno,et al.  Gene Expression Profile Prospectively Predicts Peritoneal Relapse After Curative Surgery of Gastric Cancer , 2010, Annals of Surgical Oncology.

[12]  T. Ørntoft,et al.  Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer , 2009, Clinical Cancer Research.

[13]  M. Eliáš,et al.  The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus. , 2009, Gene.

[14]  Nan Li,et al.  The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon , 2009, Nature Immunology.

[15]  Alessandro Giuliani,et al.  Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. , 2009, European journal of cancer.

[16]  R. Finnell,et al.  Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. , 2008, Genome research.

[17]  Robert A. Weinberg,et al.  Ras oncogenes: split personalities , 2008, Nature Reviews Molecular Cell Biology.

[18]  H. Morreau,et al.  Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. , 2008, The American journal of pathology.

[19]  Michal A. Kurowski,et al.  Transcriptome Profile of Human Colorectal Adenomas , 2007, Molecular Cancer Research.

[20]  Markus F Neurath,et al.  An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression , 2007, Nature Protocols.

[21]  Mingjin Yang,et al.  HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. , 2007, Biochemical and biophysical research communications.

[22]  T. Barrette,et al.  Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. , 2007, Neoplasia.

[23]  Ha-won Jeong,et al.  IQGAP1 Binds Rap1 and Modulates Its Activity* , 2004, Journal of Biological Chemistry.

[24]  T. Yeatman,et al.  Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer , 2007, Genome Biology.

[25]  A. Adjei,et al.  K-ras as a target for cancer therapy. , 2005, Biochimica et biophysica acta.

[26]  W. Kolch.  Coordinating ERK/MAPK signalling through scaffolds and inhibitors , 2005, Nature Reviews Molecular Cell Biology.

[27]  W. R. Burack,et al.  Live Cell Imaging of ERK and MEK , 2005, Journal of Biological Chemistry.

[28]  E. Nishida,et al.  Sef is a spatial regulator for Ras/MAP kinase signaling. , 2004, Developmental cell.

[29]  W. Park,et al.  Colorectal tumors frequently express phosphorylated mitogen‐activated protein kinase , 2004, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[30]  U. Lopes,et al.  RJLs: a new family of Ras-related GTP-binding proteins. , 2004, Gene.

[31]  D. Botstein,et al.  Variation in gene expression patterns in human gastric cancers. , 2003, Molecular biology of the cell.

[32]  Nan Li,et al.  Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. , 2003, Biochemical and biophysical research communications.

[33]  R. Seger,et al.  Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1 , 2001, Oncogene.

[34]  T. Jacks,et al.  Somatic activation of the K-ras oncogene causes early onset lung cancer in mice , 2001, Nature.

[35]  E. Nishida,et al.  Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism , 2000, The Journal of cell biology.

[36]  E. Krebs,et al.  Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Alan R. Saltiel,et al.  Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo , 1999, Nature Medicine.

[38]  E. Nishida,et al.  Control of the Cell Morphology and the S Phase Entry by Mitogen-activated Protein Kinase Kinase , 1999, The Journal of Biological Chemistry.

[39]  N. Ahn,et al.  Nuclear Localization of Mitogen-activated Protein Kinase Kinase 1 (MKK1) Is Promoted by Serum Stimulation and G2-M Progression , 1999, The Journal of Biological Chemistry.

[40]  E. Nishida,et al.  A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade , 1997, The Journal of Biological Chemistry.

[41]  H. Rubinfeld,et al.  Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[42]  E. Nishida,et al.  Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase , 1997, The EMBO journal.

[43]  G. Rubin,et al.  KSR modulates signal propagation within the MAPK cascade. , 1996, Genes & development.

[44]  E. Nishida,et al.  Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal* , 1996, The Journal of Biological Chemistry.

[45]  N. Ahn,et al.  Transformation of mammalian cells by constitutively active MAP kinase kinase. , 1994, Science.

[46]  C. Marshall,et al.  Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.

[47]  C. Marshall,et al.  A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21 ras to the plasma membrane , 1990, Cell.

[48]  S. Aaronson,et al.  Development of 3T3‐like lines from Balb/c mouse embryo cultures: Transformation susceptibility to SV40 , 1968, Journal of cellular physiology.