Formulation of orodispersible films for paediatric therapy: investigation of feasibility and stability for tetrabenazine as drug model

Orodispersible films (ODF) were formulated to facilitate tetrabenazine (TBZ) administration to paediatric population for the treatment of hyperkinetic movement disorders.

[1]  Bozena Michniak-Kohn,et al.  Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications. , 2012, International journal of pharmaceutics.

[2]  Cheng-ying Shen,et al.  Development and characterization of an orodispersible film containing drug nanoparticles. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  M. Otsuka,et al.  Evaluation of relationship between molecular behaviour and mechanical strength of pullulan films. , 2009, International journal of pharmaceutics.

[4]  Yue Cao,et al.  Formulation and in vitro characterization of novel sildenafil citrate-loaded polyvinyl alcohol-polyethylene glycol graft copolymer-based orally dissolving films. , 2014, International journal of pharmaceutics.

[5]  S. Chan,et al.  Effect of type and ratio of solubilising polymer on characteristics of hot-melt extruded orodispersible films. , 2013, International journal of pharmaceutics.

[6]  R. Dixit,et al.  Oral strip technology: overview and future potential. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Catherine Tuleu,et al.  Guideline on Pharmaceutical Development of Medicines for Paediatric Use , 2008 .

[8]  Francesca Selmin,et al.  Fast dissolving films made of maltodextrins. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[9]  S. Clas,et al.  Crystallization inhibition in solid dispersions of MK-0591 and poly(vinylpyrrolidone) polymers. , 2000, Journal of pharmaceutical sciences.

[10]  Jason T McConville,et al.  Manufacture and characterization of mucoadhesive buccal films. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[11]  V. Khutoryanskiy,et al.  Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose. , 2008, Macromolecular bioscience.

[12]  P. Kleinebudde,et al.  Development of orodispersible polymer films with focus on the solid state characterization of crystalline loperamide. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[13]  W. Ondo,et al.  Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. , 2012, Clinical therapeutics.

[14]  C. Roberts,et al.  Dissolution methodology for taste masked oral dosage forms. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[15]  J. Walsh,et al.  Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients. , 2014, Advanced drug delivery reviews.

[16]  J. Boateng,et al.  Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs , 2012, Drug development and industrial pharmacy.

[17]  S. Jain,et al.  Tetrabenazine therapy of pediatric hyperkinetic movement disorders , 2006, Movement disorders : official journal of the Movement Disorder Society.

[18]  M. Mohamed,et al.  Fast-dissolving sublingual films of terbutaline sulfate: formulation and in vitro/in vivo evaluation. , 2013, Molecular pharmaceutics.

[19]  V. Fabiano,et al.  Paediatric pharmacology: remember the excipients. , 2011, Pharmacological research.

[20]  Naseem A. Charoo,et al.  Pediatric drug development: formulation considerations , 2014, Drug development and industrial pharmacy.

[21]  Sandeep Arora,et al.  Orally dissolving strips: A new approach to oral drug delivery system , 2013, International journal of pharmaceutical investigation.

[22]  D. Bikiaris,et al.  Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[23]  Harsh Chauhan,et al.  Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[24]  D. Guay Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. , 2010, The American journal of geriatric pharmacotherapy.

[25]  Lynne S Taylor,et al.  Evaluation of amorphous solid dispersion properties using thermal analysis techniques. , 2012, Advanced drug delivery reviews.

[26]  H. Fessi,et al.  Structural elucidation of two photolytic degradation products of tetrabenazine. , 2014, Journal of pharmaceutical and biomedical analysis.

[27]  R. Strickley,et al.  Pediatric drugs--a review of commercially available oral formulations. , 2008, Journal of pharmaceutical sciences.

[28]  E. Saitoh,et al.  Development of an easily swallowed film formulation. , 2008, International journal of pharmaceutics.

[29]  K. Sandeep,et al.  Polyvinylpyrrolidone oral films of enrofloxacin: film characterization and drug release. , 2014, International journal of pharmaceutics.

[30]  A. Bajaj,et al.  Polymers used for Fast Disintegrating Oral Films: A Review , 2013 .

[31]  Bruno C. Hancock,et al.  Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates. , 1995, Journal of pharmaceutical sciences.

[32]  B. Sravani,et al.  Development and Evaluation of Mouth Dissolving Films of Sumatriptan Succinate for Better Therapeutic Efficacy , 2013 .

[33]  George Zografi,et al.  Physical Properties of Solid Molecular Dispersions of Indomethacin with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl-acetate) in Relation to Indomethacin Crystallization , 1999, Pharmaceutical Research.