Development of an experimental test bench for the measurement of fluid dynamic behavior of mechanical heart valve

In this paper an experimental test bench for mechanical heart valve and the procedure for non-invasive optical measurement are reported. Fluidynamic behaviour of a bileafleat mechanical valve in steady state and pulsed flow conditions has been studied. Laser Doppler Anemometry (LDA) is used to access velocity and turbulence values at different distances before and after the mechanical valve. Data obtained can be related, according to the literature, to typical pathologies affecting patients who underwent surgical procedures to implant mechanical heart valves. In particular thrombosis and hemolysis can be related to high levels of shear stress affecting blood cells. Measurements of velocity, turbulence and shear stresses have been performed.

[1]  V. Turitto,et al.  Platelet interaction with subendothelium in flowing rabbit blood: effect of blood shear rate. , 1979, Microvascular research.

[2]  D. Giddens,et al.  Steady flow in a model of the human carotid bifurcation. Part II--laser-Doppler anemometer measurements. , 1982, Journal of biomechanics.

[3]  A P Yoganathan,et al.  In-vitro fluid dynamic characteristics of the abiomed trileaflet heart valve prosthesis. , 1983, Journal of biomechanical engineering.

[4]  N H Hwang,et al.  Human red blood cell hemolysis in a turbulent shear flow: contribution of Reynolds shear stresses. , 1984, Biorheology.

[5]  L V McIntire,et al.  Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. , 1989, Science.

[6]  H. Weiss,et al.  The effect of shear rate on platelet interaction with subendothelium exposed to citrated human blood. , 1980, Microvascular research.

[7]  H N Sabbah,et al.  Turbulent stresses in the region of aortic and pulmonary valves. , 1982, Journal of biomechanical engineering.

[8]  A Kamiya,et al.  Roles of fluid shear stress in physiological regulation of vascular structure and function. , 1988, Biorheology.

[9]  R S Cobbold,et al.  High resolution photochromic dye method for pulsatile flow studies. , 1990, Monographs on atherosclerosis.

[10]  Alfrey Cp,et al.  Erythrocyte damage and destruction induced by shearing stress. , 1968 .

[11]  ROBERT M. NEREM,et al.  Velocity Distribution and Intimal Proliferation in Autologous Vein Grafts in Dogs , 1978, Circulation research.