Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014)

Introduction: Our previous scientometric review of regenerative medicine provides a snapshot of the fast-growing field up to the end of 2011. The new review identifies emerging trends and new developments appearing in the literature of regenerative medicine based on relevant articles and reviews published between 2000 and the first month of 2014. Areas covered: Multiple datasets of publications relevant to regenerative medicine are constructed through topic search and citation expansion to ensure adequate coverage of the field. Networks of co-cited references representing the literature of regenerative medicine are constructed and visualized based on a combined dataset of 71,393 articles published between 2000 and 2014. Structural and temporal dynamics are identified in terms of most active topical areas and cited references. New developments are identified in terms of newly emerged clusters and research areas. Disciplinary-level patterns are visualized in dual-map overlays. Expert opinion: While research in induced pluripotent stem cells remains the most prominent area in the field of regenerative medicine, research related to clinical and therapeutic applications in regenerative medicine has experienced a considerable growth. In addition, clinical and therapeutic developments in regenerative medicine have demonstrated profound connections with the induced pluripotent stem cell research and stem cell research in general. A rapid adaptation of graphene-based nanomaterials in regenerative medicine is evident. Both basic research represented by stem cell research and application-oriented research typically found in tissue engineering are now increasingly integrated in the scientometric landscape of regenerative medicine. Tissue engineering is an interdisciplinary field in its own right. Advances in multiple disciplines such as stem cell research and graphene research have strengthened the connections between tissue engineering and regenerative medicine.

[1]  J. Gurdon,et al.  The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. , 1962, Journal of embryology and experimental morphology.

[2]  Henry G. Small,et al.  Co-citation in the scientific literature: A new measure of the relationship between two documents , 1973, J. Am. Soc. Inf. Sci..

[3]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[4]  Domain of visualization , 1987, COMG.

[5]  I. Wilmut,et al.  Sheep cloned by nuclear transfer from a cultured cell line , 1996, Nature.

[6]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[7]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[8]  Chaomei Chen,et al.  Searching for intellectual turning points: Progressive knowledge domain visualization , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Jain.  Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[10]  Chaomei Chen,et al.  Web site design with the patron in mind: A step-by-step guide for libraries , 2006 .

[11]  Chaomei Chen,et al.  CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature , 2006, J. Assoc. Inf. Sci. Technol..

[12]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[13]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[14]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2007, Nature.

[15]  Sara Mantero,et al.  Clinical transplantation of a tissue-engineered airway , 2008, The Lancet.

[16]  Doris A Taylor,et al.  Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart , 2008, Nature Medicine.

[17]  H. Schöler,et al.  A combined chemical and genetic approach for the generation of induced pluripotent stem cells. , 2008, Cell stem cell.

[18]  S. Badylak,et al.  Extracellular matrix as a biological scaffold material: Structure and function. , 2009, Acta biomaterialia.

[19]  Joshua M Hare,et al.  A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. , 2009, Journal of the American College of Cardiology.

[20]  Wei Wang,et al.  piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells , 2009, Nature.

[21]  C. Lutzko,et al.  Molecular Characterization of the Human NANOG Protein , 2009, Stem cells.

[22]  T. Ichisaka,et al.  Suppression of induced pluripotent stem cell generation by the p53–p21 pathway , 2009, Nature.

[23]  Martin J. Aryee,et al.  Epigenetic memory in induced pluripotent stem cells , 2010, Nature.

[24]  T. Okano,et al.  The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering , 2010 .

[25]  F. Watt,et al.  The therapeutic potential of stem cells , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[26]  Hiroshi Yagi,et al.  Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix , 2010, Nature Medicine.

[27]  J. Rossant,et al.  The genetics of induced pluripotency. , 2010, Reproduction.

[28]  Evelyn K F Yim,et al.  Nanotopography/mechanical induction of stem-cell differentiation. , 2010, Methods in cell biology.

[29]  Carl T. Bergstrom,et al.  Mapping Change in Large Networks , 2008, PloS one.

[30]  C. Sommer,et al.  Experimental approaches for the generation of induced pluripotent stem cells , 2010, Stem Cell Research & Therapy.

[31]  A. Nathwani,et al.  An introduction to induced pluripotent stem cells , 2010, British journal of haematology.

[32]  B. Venerando,et al.  Cell reprogramming: expectations and challenges for chemistry in stem cell biology and regenerative medicine , 2010, Cell Death and Differentiation.

[33]  Andre Levchenko,et al.  Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells , 2010, Advanced materials.

[34]  Kevin Eggan,et al.  Progress toward the clinical application of patient-specific pluripotent stem cells. , 2010, The Journal of clinical investigation.

[35]  D. Mooney,et al.  Growth factor delivery-based tissue engineering: general approaches and a review of recent developments , 2011, Journal of The Royal Society Interface.

[36]  Mikaël M. Martino,et al.  Biomimetic materials in tissue engineering , 2010 .

[37]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[38]  V. Vedantham,et al.  Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors , 2010, Cell.

[39]  M. Alexander,et al.  Surface strategies for control of neuronal cell adhesion: A review , 2010 .

[40]  Yi Yan Yang,et al.  Synthetic hydrogels for controlled stem cell differentiation , 2010 .

[41]  Min Zhang,et al.  Toward delivery of multiple growth factors in tissue engineering. , 2010, Biomaterials.

[42]  A. Schnerch,et al.  Distinguishing Between Mouse and Human Pluripotent Stem Cell Regulation: The Best Laid Plans of Mice and Men , 2010, Stem cells.

[43]  Martin Fussenegger,et al.  Scaffold-free cell delivery for use in regenerative medicine. , 2010, Advanced drug delivery reviews.

[44]  G. Shi,et al.  Self-assembled graphene hydrogel via a one-step hydrothermal process. , 2010, ACS nano.

[45]  W. Lowry,et al.  Roadblocks en route to the clinical application of induced pluripotent stem cells , 2010, Journal of Cell Science.

[46]  Alexander Meissner,et al.  Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. , 2010, Cell stem cell.

[47]  K. Hochedlinger,et al.  Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells , 2010, Nature Biotechnology.

[48]  Jeff W M Bulte,et al.  Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. , 2010, Archives of neurology.

[49]  K. Hochedlinger,et al.  Induced pluripotency: history, mechanisms, and applications. , 2010, Genes & development.

[50]  T. Okano,et al.  Cell sheet engineering: a unique nanotechnology for scaffold‐free tissue reconstruction with clinical applications in regenerative medicine , 2010, Journal of internal medicine.

[51]  R. Stewart,et al.  Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells , 2011, Nature.

[52]  Francisco Herrera,et al.  Science mapping software tools: Review, analysis, and cooperative study among tools , 2011, J. Assoc. Inf. Sci. Technol..

[53]  Tal Dvir,et al.  Nanotechnological strategies for engineering complex tissues. , 2020, Nature nanotechnology.

[54]  Adrian P Gee,et al.  Inducible apoptosis as a safety switch for adoptive cell therapy. , 2011, The New England journal of medicine.

[55]  Hao Liu,et al.  CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. , 2011, The Journal of clinical investigation.

[56]  Aldo R Boccaccini,et al.  A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. , 2011, Biomaterials.

[57]  Michel Sadelain,et al.  Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. , 2011, Blood.

[58]  M. Longaker,et al.  Concise Review: Adipose‐Derived Stromal Cells for Skeletal Regenerative Medicine , 2011, Stem cells.

[59]  Federica Chiellini,et al.  Chitosan—A versatile semi-synthetic polymer in biomedical applications , 2011 .

[60]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[61]  Timothy J. Nelson,et al.  The science and ethics of induced pluripotency: what will become of embryonic stem cells? , 2011, Mayo Clinic proceedings.

[62]  Stephen F Badylak,et al.  An overview of tissue and whole organ decellularization processes. , 2011, Biomaterials.

[63]  J. Hare,et al.  Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. , 2011, Circulation research.

[64]  Jason A. Burdick,et al.  Hyaluronic Acid Hydrogels for Biomedical Applications , 2011, Advanced materials.

[65]  Marcus F Stoddard,et al.  Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial , 2011, The Lancet.

[66]  M. Ehinger,et al.  CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization. , 2011, Blood.

[67]  E. Kirkness,et al.  Somatic coding mutations in human induced pluripotent stem cells , 2011, Nature.

[68]  Mudit Gupta,et al.  Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. , 2011, Cell stem cell.

[69]  Lior Gepstein,et al.  Modelling the long QT syndrome with induced pluripotent stem cells , 2011, Nature.

[70]  Shinya Yamanaka,et al.  Immunogenicity of induced pluripotent stem cells. , 2011, Circulation research.

[71]  A. Bagg,et al.  Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. , 2011, The New England journal of medicine.

[72]  Chaomei Chen,et al.  Predictive effects of structural variation on citation counts , 2012, J. Assoc. Inf. Sci. Technol..

[73]  Daniel Berman,et al.  Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial , 2012, The Lancet.

[74]  Chaomei Chen,et al.  Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace , 2012, Expert opinion on biological therapy.

[75]  Yan Jin,et al.  Prospects for translational regenerative medicine. , 2012, Biotechnology advances.

[76]  Shiaw-Min Hwang,et al.  A graphene-based platform for induced pluripotent stem cells culture and differentiation. , 2012, Biomaterials.

[77]  George Q. Daley,et al.  Reprogramming Cellular Identity for Regenerative Medicine , 2012, Cell.

[78]  R. Herberman,et al.  Adoptive Immunotherapy of Cancer , 1994, Clinical Immunotherapeutics.

[79]  C. Turtle,et al.  Engineered T cells for anti-cancer therapy. , 2012, Current opinion in immunology.

[80]  S. Yamanaka,et al.  An Efficient Nonviral Method to Generate Integration‐Free Human‐Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells , 2013, Stem cells.

[81]  Chi Cheng,et al.  Self‐Supporting Graphene Hydrogel Film as an Experimental Platform to Evaluate the Potential of Graphene for Bone Regeneration , 2013 .

[82]  S. Gottschalk,et al.  Design and development of therapies using chimeric antigen receptor‐expressing T cells , 2014, Immunological reviews.

[83]  Charles A. Vacanti,et al.  Stimulus-triggered fate conversion of somatic cells into pluripotency , 2014, Nature.

[84]  Masayuki Yamato,et al.  Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine , 2013, Archives of Pharmacal Research.

[85]  Chaomei Chen,et al.  Patterns of connections and movements in dual‐map overlays: A new method of publication portfolio analysis , 2014, J. Assoc. Inf. Sci. Technol..

[86]  S. Riddell,et al.  Design and implementation of adoptive therapy with chimeric antigen receptor‐modified T cells , 2014, Immunological reviews.

[87]  Donald O Freytes,et al.  Reprint of: Extracellular matrix as a biological scaffold material: Structure and function. , 2015, Acta biomaterialia.

[88]  Marcia Simon,et al.  Hydrogels for Regenerative Medicine , 2016 .