Factores de riesgo cardiovascular en el ritmo circadiano del infarto agudo de miocardio

Introduccion y objetivos El objetivo de este trabajo es analizar la influencia de los factores de riesgo cardiovascular modificables en el ritmo circadiano del infarto agudo de miocardio. Pacientes y metodo. Analisis retrospectivo de 54.249 pacientes incluidos en la base de datos del proyecto ARIAM con diagnostico de infarto agudo de miocardio. Se analizan las variables hora de inicio, edad, sexo, cardiopatia isquemica previa, estado en el momento del alta de la unidad coronaria, antecedentes familiares de cardiopatia isquemica, accidente cerebrovascular previo, hipertension arterial, dislipemia, diabetes, tabaquismo y reinfarto. El analisis de ritmo se ha efectuado utilizando un test simple de igualdad de series basado en el analisis cosinor de multiples sinusoides, eligiendo 3 armonicos (24,12 y 8 h) para su ajuste. Resultados La hora de inicio del infarto muestra ritmo circadiano (p Conclusiones El infarto agudo de miocardio presenta ritmo circadiano. La diabetes, el tabaquismo y el reinfarto pueden modificar el ritmo habitual de aparicion del infarto.

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