This article presents an evaluation of the electronic nose technology as an alternative to sensory analysis for assessing the effectiveness of biofilters. An AromaScan ® A32S electronic nose and a human panel at Duke University’s Taste and Smell Research Lab were used to measure typical volatile compounds from swine confinement buildings. Chemometrics techniques were employed to predict the olfactory scores of the human panel from the electronic nose data. The cross-sensitivity of the sensor array to the humidity of the samples is discussed. Our results indicate that the electronic nose generates responses that are correlated with sensory analysis ratings of swine malodors at different concentrations.