Magnesium lithospermate B ameliorates diabetic nephropathy by suppressing the uremic toxin formation mediated by gut microbiota.

[1]  M. Shephard,et al.  Results From 16 Years of Quality Surveillance of Urine Albumin to Creatinine Ratio Testing for a National Indigenous Point-of-Care Testing Program. , 2020, Archives of pathology & laboratory medicine.

[2]  D. Fouque,et al.  A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease , 2020, Scientific Reports.

[3]  C. Mackay,et al.  Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid-Mediated Activation of G Protein-Coupled Receptors GPR43 and GPR109A. , 2020, Journal of the American Society of Nephrology : JASN.

[4]  Jianhua Shen,et al.  Quantification of microbiota-related phenols and aromatic acids in mouse feces of a diabetic nephropathy model by simultaneous BDAPE derivatization using ultra-performance liquid chromatography-tandem mass spectrometry , 2020, Analytical and Bioanalytical Chemistry.

[5]  Guangji Wang,et al.  Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay , 2020, Trends in Endocrinology & Metabolism.

[6]  Xiping Xu,et al.  Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents , 2020, Gut.

[7]  Guo-sheng Teng,et al.  A rapid and convenient derivatization method for quantitation of short-chain fatty acids in human feces by ultra-performance liquid chromatography-tandem mass spectrometry. , 2020, Rapid communications in mass spectrometry : RCM.

[8]  M. Lämmerhofer,et al.  Stereoselective separation of underivatized and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatized amino acids using zwitterionic quinine and quinidine type stationary phases by liquid chromatography-High resolution mass spectrometry. , 2019, Journal of chromatography. A.

[9]  B. Vervliet,et al.  The role of short-chain fatty acids in microbiota–gut–brain communication , 2019, Nature Reviews Gastroenterology & Hepatology.

[10]  T. Abe,et al.  Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease , 2019, Nature Communications.

[11]  Ming Wang,et al.  Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan , 2019, Nature Communications.

[12]  T. Spector,et al.  Interplay between the human gut microbiome and host metabolism , 2019, Nature Communications.

[13]  S. Hazen,et al.  Dietary metabolism, the gut microbiome, and heart failure , 2018, Nature Reviews Cardiology.

[14]  E. Mishima,et al.  Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. , 2018, American journal of physiology. Renal physiology.

[15]  Min Liu,et al.  "Cocktail" of Xenobiotics at Human Relevant Levels Reshapes the Gut Bacterial Metabolome in a Species-Specific Manner. , 2018, Environmental science & technology.

[16]  P. Stenvinkel,et al.  Effects of probiotic supplementation on inflammatory biomarkers and uremic toxins in non-dialysis chronic kidney patients: A double-blind, randomized, placebo-controlled trial , 2018, Journal of Functional Foods.

[17]  C. Pepine,et al.  The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease , 2018, Nature Reviews Nephrology.

[18]  Jing Zhao,et al.  Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy , 2018, Acta Pharmacologica Sinica.

[19]  J. Lewis,et al.  Update on Diabetic Nephropathy: Core Curriculum 2018. , 2018, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[20]  David S. Wishart,et al.  MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis , 2018, Nucleic Acids Res..

[21]  Kyongbum Lee,et al.  Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages , 2018, Cell reports.

[22]  G. Nolan,et al.  A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites , 2017, Nature.

[23]  D. Chiu,et al.  Tryptophan as a surrogate prognostic marker for diabetic nephropathy , 2017, Journal of diabetes investigation.

[24]  A. Friedman,et al.  Diagnosis and Management of Type 2 Diabetic Kidney Disease. , 2017, Clinical journal of the American Society of Nephrology : CJASN.

[25]  H. Chung,et al.  Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation , 2017, Phytotherapy research : PTR.

[26]  M. Vaneechoutte,et al.  p-Cresyl Sulfate , 2017, Toxins.

[27]  J. Pluznick.  Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors. , 2016, Kidney international.

[28]  L. Gnudi,et al.  Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms , 2016, Trends in Endocrinology & Metabolism.

[29]  F. Bäckhed,et al.  From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites , 2016, Cell.

[30]  Vinícius Andrade-Oliveira,et al.  The microbiota and chronic kidney diseases: a double-edged sword , 2016, Clinical & translational immunology.

[31]  E. Mishima,et al.  Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD. , 2015, Journal of the American Society of Nephrology : JASN.

[32]  Guoyao Wu,et al.  Amino acid metabolism in intestinal bacteria and its potential implications for mammalian reproduction. , 2015, Molecular human reproduction.

[33]  C. Dejong,et al.  The Role of Microbial Amino Acid Metabolism in Host Metabolism , 2015, Nutrients.

[34]  Andrew H. Van Benschoten,et al.  Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. , 2014, Cell host & microbe.

[35]  L. Gesualdo,et al.  Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN) , 2014, PloS one.

[36]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[37]  D. Raj,et al.  The gut microbiome, kidney disease, and targeted interventions. , 2014, Journal of the American Society of Nephrology : JASN.

[38]  Barbara M. Bakker,et al.  Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[39]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[40]  B. Stecher,et al.  The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. , 2013, Kidney international.

[41]  H. Flint,et al.  Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. , 2013, Molecular nutrition & food research.

[42]  G. Andersen,et al.  Chronic kidney disease alters intestinal microbial flora. , 2013, Kidney international.

[43]  Wen-Yu Wu,et al.  Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components , 2012, Acta Pharmacologica Sinica.

[44]  T. Meyer,et al.  Uremic solutes from colon microbes. , 2012, Kidney international.

[45]  Shi-Chung Chang,et al.  Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition , 2012, PloS one.

[46]  T. Niwa,et al.  Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production , 2012, Analytical and Bioanalytical Chemistry.

[47]  Patrick J Heagerty,et al.  Temporal trends in the prevalence of diabetic kidney disease in the United States. , 2011, JAMA.

[48]  Ping Xie,et al.  A glimpse of various pathogenetic mechanisms of diabetic nephropathy. , 2011, Annual review of pathology.

[49]  I-Wen Wu,et al.  p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease , 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[50]  E. Kang,et al.  Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction. , 2010, Cardiovascular research.

[51]  B. Finlay,et al.  Gut microbiota in health and disease. , 2010, Physiological reviews.

[52]  Jai Radhakrishnan,et al.  Pathologic classification of diabetic nephropathy. , 2010, Journal of the American Society of Nephrology : JASN.

[53]  Z. Zuo,et al.  Effect of sodium caprate on the oral absorptions of danshensu and salvianolic acid B. , 2009, International journal of pharmaceutics.

[54]  W. R. Wikoff,et al.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites , 2009, Proceedings of the National Academy of Sciences.

[55]  Yueming Ma,et al.  A solid-phase extraction method for high-performance liquid chromatographic determination of salvianolic acid B in rabbit plasma: application to pharmacokinetic study. , 2007, Biomedical chromatography : BMC.

[56]  R. Ley,et al.  Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine , 2006, Cell.

[57]  Jianping Jin,et al.  Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. , 2005, Diabetes.

[58]  N. Nakamura,et al.  Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat. , 2004, Planta medica.

[59]  B. Cha,et al.  Delayed treatment with lithospermate B attenuates experimental diabetic renal injury. , 2003, Journal of the American Society of Nephrology : JASN.

[60]  T. Selmer,et al.  p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol. , 2001, European journal of biochemistry.

[61]  C. Metges.  Contribution of microbial amino acids to amino acid homeostasis of the host. , 2000, The Journal of nutrition.

[62]  Liangyu Li.  Biologically active components from traditional Chinese medicines , 1998 .

[63]  T. Coffman,et al.  Modelling diabetic nephropathy in mice , 2018, Nature Reviews Nephrology.

[64]  D. Raj,et al.  Gut microbiome in chronic kidney disease: challenges and opportunities , 2017, Translational research : the journal of laboratory and clinical medicine.

[65]  B. Sampaio-Maia,et al.  The Role of the Gut Microbiome on Chronic Kidney Disease. , 2016, Advances in applied microbiology.

[66]  S. Salzberg,et al.  FLASH: fast length adjustment of short reads to improve genome assemblies , 2011, Bioinform..

[67]  Robert C. Edgar,et al.  Search and clustering orders of magnitude faster than BLAST , 2010 .