Blockade of interleukin 6 by rat anti-mouse interleukin 6 receptor antibody promotes fracture healing

[1]  Guanghui Liu,et al.  TNF-α is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose. , 2016, Cytokine.

[2]  S. Papapoulos,et al.  Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis , 2015, Drugs.

[3]  M. Suzuki,et al.  THU0061 The Effect of Anti-IL-6 Receptor Antibody on Cartilage Destruction in a Mouse Model of Collagen-Induced Arthritis , 2015 .

[4]  M. Amling,et al.  Midkine-Deficiency Delays Chondrogenesis during the Early Phase of Fracture Healing in Mice , 2014, PloS one.

[5]  Y. Ohira,et al.  Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages. , 2014, Biochimica et biophysica acta.

[6]  S. Achilefu,et al.  Intravenous Application of CD271-selected Mesenchymal Stem Cells During Fracture Healing , 2014, Journal of orthopaedic trauma.

[7]  M. Betsch,et al.  The early phase influence of bone marrow concentrate on metaphyseal bone healing. , 2013, Injury.

[8]  P. Tak,et al.  Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis , 2013, Annals of the rheumatic diseases.

[9]  J. Cauley,et al.  Public health impact of osteoporosis. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  Kylie A Alexander,et al.  Unraveling macrophage contributions to bone repair. , 2013, BoneKEy reports.

[11]  H. Im,et al.  Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. , 2013, Gene.

[12]  C. Irvin,et al.  Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases , 2012, International journal of biological sciences.

[13]  H. Aro,et al.  Different profiles of circulating sclerostin, IL-6 and TNF-alpha after hip fracture , 2012 .

[14]  S. Cummings,et al.  Rapidly increasing rates of hip fracture in Beijing, China , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  T. Cooney,et al.  Effects of Interleukin‐6 Ablation on Fracture Healing in Mice , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  Jian-zheng Zhang,et al.  Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients. , 2011, Injury.

[17]  D. Tweardy,et al.  IL-6-Mediated Activation of Stat3α Prevents Trauma/Hemorrhagic Shock-Induced Liver Inflammation , 2011, PloS one.

[18]  L. Koenderman,et al.  Systemic inflammation and fracture healing , 2011, Journal of leukocyte biology.

[19]  A. Kimura,et al.  IL‐6: Regulator of Treg/Th17 balance , 2010, European journal of immunology.

[20]  G. Duda,et al.  The early fracture hematoma and its potential role in fracture healing. , 2010, Tissue engineering. Part B, Reviews.

[21]  L. Gibson,et al.  Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway. , 2009, ATS 2009.

[22]  C. Bäckesjö,et al.  IL-6 receptor expression and IL-6 effects change during osteoblast differentiation. , 2008, Cytokine.

[23]  C. Kaps,et al.  Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study , 2008, Arthritis research & therapy.

[24]  N. Pleshko Camacho,et al.  Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. , 2007, Bone.

[25]  R. Kurzrock,et al.  Interleukin‐6 and its receptor in cancer , 2007, Cancer.

[26]  M. Scherer,et al.  Roles of neutrophil‐mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats , 2006, Journal of leukocyte biology.

[27]  M. Gardner,et al.  Osteoporosis and Skeletal Fractures , 2006, HSS Journal.

[28]  Kozo Nakamura,et al.  Involvement of Endogenous Bone Morphogenetic Protein (BMP) 2 and BMP6 in Bone Formation* , 2005, Journal of Biological Chemistry.

[29]  R. Iorio,et al.  Total Hip Arthroplasty: Optimal Treatment for Displaced Femoral Neck Fractures in Elderly Patients , 2004, Clinical orthopaedics and related research.

[30]  N. Fazzalari,et al.  Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. , 2004, Bone.

[31]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[32]  R. Price,et al.  Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. , 2002, Arthritis and rheumatism.

[33]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[34]  A. McMahon,et al.  Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. , 2001, The Journal of clinical investigation.

[35]  T. Kishimoto,et al.  Interleukin-6 and its receptor in autoimmunity. , 1992, Journal of autoimmunity.

[36]  N. Rozen,et al.  Role of bone regeneration and turnover modulators in control of fracture. , 2007, Critical reviews in eukaryotic gene expression.

[37]  A. Levine,et al.  The role of the interleukin-6/gp130 signaling pathway in bone metabolism. , 2006, Vitamins and hormones.

[38]  A. Aho Electron microscopic and histological observations on fracture repair in young and old rats. , 1966, Acta pathologica et microbiologica Scandinavica.

[39]  Aho Aj Electron microscopic and histological observations on fracture repair in young and old rats. , 1966 .